CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD664
Family Name Serine/threonine-protein kinase mTOR Inhibitor AZD2014 Family
No. of Seeds 2 No. of Other Members 41
Family Centroid CFAMM00167788 Functional Category Clinical Trial Drug with Natural Product
Superfamily Serine/threonine-protein kinase mTOR and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Binder Superfamily
Class Class 1233

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Prothrombin Inhibitor Dabigatran Family 7 182
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
GDC-0349 family 44 77
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 37 10
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
Toll-like receptor 7 Ligand GS-9620 Family 2 4
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Amine oxidase [flavin-containing] A Inhibitor 3-benzyl-n-(2-mo... 2 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 25 4
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 5 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Transient receptor potential cation channel subfamily V member... 1 4
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 1 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 2 4
Epidermal growth factor receptor ligand pyrido[4,3-d]pyrimidin... 11 0
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
Dihydrofolate reductase and Thymidylate synthase inhibitor 2-[... 10 5
Glucosylceramidase and Alpha-galactosidase A inhibitor AC1NNEG... 4 5
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
Serine/threonine-protein kinase mTOR inhibitor SureCN2707225 f... 29 4
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-088SNX f... 1 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 1
Mitogen-activated protein kinase 14 inhibitor SureCN3305171 fa... 1 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Transient receptor potential cation channel subfamily V member... 2 1
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Transient receptor potential cation channel subfamily V member... 4 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Microsomal triglyceride transfer protein large subunit inhibit... 13 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Epidermal growth factor receptor ligand AGN-PC-073LJS family 4 0
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
P2Y purinoceptor 12 inhibitor (4S)-4-[[6-[4-[2-(methylamino)-2... 51 8
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 12 0
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00167783 CHEMBL2181658 Bioactive 1-[4-(7-benzoyl-4-morpholin-4-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl)phenyl]-3-ethylurea
CFAMM00167788 DNCL002158 Clinical Trial Drug AZD2014

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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