CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD67
Family Name Gamma-secretase subunit APH-1B Inhibitor E2012 Family
No. of Seeds 3 No. of Other Members 67
Family Centroid CFAMM00132534 Functional Category Clinical Trial Drug with Natural Product
Superfamily Gamma-secretase subunit APH-1B Inhibitor E2012 Superfamily
Class Class 869

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Smoothened homolog Inhibitor LDE225 Family 3 76
MK-6096 family 3 69
Eluxadoline family 4 85
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Glucokinase Inhibitor GKA1 Family 2 67
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Vascular endothelial growth factor receptor 1 and Vascular end... 4 44
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
B2 bradykinin receptor Ligand FR-173657 Family 44 180
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 4 4
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Mitogen-activated protein kinase 14 inhibitor DEL-B, 14b family 2 0
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 2
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
ALK tyrosine kinase receptor and Insulin receptor ligand SureC... 7 1
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Adenosine receptor A2b and Adenosine receptor A2a ligand AGN-P... 2 0
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Cytochrome P450 26A1 inhibitor AGN-PC-09MAZ3 family 1 7
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Fatty-acid amide hydrolase 1 inhibitor 2-(1,3-dihydroisoindol-... 2 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 7
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 3 0
5-hydroxytryptamine receptor 1A ligand 4-chloro-N-[(2S)-2-[4-(... 4 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 1
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 1... 1 0
Growth hormone secretagogue receptor type 1 and Potassium volt... 3 0
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Coagulation factor X inhibitor AGN-PC-07C10A family 3 2
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
ALK tyrosine kinase receptor ligand 4-fluoro-N-[1-[4-(propan-2... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 3 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 2
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Melanocortin receptor 4 ligand AGN-PC-076AMT family 2 9
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Mitogen-activated protein kinase 14 inhibitor 4-[4-(4-fluoroph... 1 5
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 2
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
C-C chemokine receptor type 3 ligand SureCN6338683 family 1 2
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 2 2
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RCV family 2 1
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-077D0D family 3 0
Delta-type opioid receptor and Kappa-type opioid receptor liga... 3 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Diacylglycerol O-acyltransferase 1 inhibitor SureCN2789698 family 2 8
Cytochrome P450 11B1, mitochondrial and Aromatase inhibitor CH... 2 1
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8919280 f... 23 18
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-00FHC0 f... 2 0
Sterol O-acyltransferase 1 inhibitor SureCN9430680 family 7 3
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8919926 f... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00132532 CHEMBL456233 Bioactive N-[4-[4-[2-(2-fluoroethoxy)phenyl]piperazin-1-yl]butyl]-4-imidazol-1-ylbenzamide
CFAMM00132534 DCL000107 Clinical Trial Drug E2012

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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