CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD670
Family Name SB1518 family
No. of Seeds 7 No. of Other Members 103
Family Centroid CFAMM00167999 Functional Category Clinical Trial Drug with Natural Product
Superfamily SB1518 Superfamily
Class Class 831

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Mepyramine Family 5 65
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Mitogen-activated protein kinase 12 Inhibitor Birb 796 Family 20 43
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
AP26113 family 16 90
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Melanin-concentrating hormone receptor 1 Ligand ADS-102891 Family 6 51
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 3
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 2 3
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Coagulation factor X and Prothrombin Inhibitor BMS-344577 Family 13 12
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 50 36
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
5-hydroxytryptamine receptor 1A Ligand CP-293019 Family 9 24
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Metabotropic glutamate receptor 5 Ligand 7-(4,6-dimethoxypyrim... 2 0
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Metabotropic glutamate receptor 1 Ligand 4-(cyclohexyloxy)quin... 1 4
Potassium voltage-gated channel subfamily H member 2 Ligand (1... 64 70
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Deoxycytidine kinase inhibitor AGN-PC-07Z9C8 family 5 3
Deoxycytidine kinase inhibitor AGN-PC-07Z9GO family 10 2
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 6
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2J2 inhib... 1 7
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
Proto-oncogene tyrosine-protein kinase Src and Cyclin-dependen... 2 1
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 16
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 8 1
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 5 45
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Cathepsin S and Cathepsin K inhibitor AGN-PC-07YOWS family 4 6
Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family 3 11
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
Survival motor neuron protein inhibitor CHEMBL1307497 family 1 2
Dual specificity protein kinase CLK1 and Dual specificity prot... 2 14
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 8
Prostaglandin D2 receptor ligand 3-[2-methoxy-6-[2-(4-methoxyp... 2 12
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Epidermal growth factor receptor ligand Pyrimido[4,5-b]indole ... 1 4
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Neuropeptide Y receptor type 5 ligand 3-[2-[6-[2-[(2-methylpro... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
ALK tyrosine kinase receptor and Insulin receptor ligand SureC... 7 1
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 3 21
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Glycogen synthase kinase-3 beta inhibitor 6-[(2S)-2-(2-methoxy... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Dihydrofolate reductase inhibitor 7-(3,4-dimethoxyphenyl)-6-me... 1 3
Dihydrofolate reductase inhibitor 7-(2-ethoxynaphthalen-1-yl)-... 3 2
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 0
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor 2-[4-[... 2 6
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 2
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 1 0
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... 3 3
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 42 3
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 24 5
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
ALK tyrosine kinase receptor ligand CHEMBL1946804 family 3 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0074... 2 3
Xanthine dehydrogenase/oxidase inhibitor 4-[[4-(2-aminopyrimid... 3 16
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 6 13
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 18 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 1 1
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Beta-secretase 1 and Beta-secretase 2 inhibitor 7-fluoro-3-(5-... 2 7
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Cathepsin K and Cathepsin L1 inhibitor 2-Cyano-pyrimidine, 17a... 5 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 1
Glucose-dependent insulinotropic receptor ligand (2R)-2-[1-(5-... 4 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Transient receptor potential cation channel subfamily V member... 2 4
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
TRAF2 and NCK-interacting protein kinase and Serine/threonine-... 2 2
TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... 4 1
Xanthine dehydrogenase/oxidase inhibitor 5-(2-amino-4-oxo-1H-p... 8 30
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-(5-... 2 1
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 12 2
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 4 9
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Orexin receptor type 1 and Orexin receptor type 2 ligand (1R,2... 6 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 1 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Receptor tyrosine-protein kinase erbB-2 ligand SureCN3374869 f... 4 8
Mitogen-activated protein kinase 14 inhibitor SureCN4913214 fa... 1 2
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Epidermal growth factor receptor ligand AGN-PC-078X8C family 10 8
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0
Dihydrofolate reductase and Dihydrofolate reductase type 1 inh... 8 1
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 1 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Glucagon receptor ligand SureCN2647807 family 3 7
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 12
Adenosine kinase inhibitor SureCN8139139 family 1 1
Mitogen-activated protein kinase 10 inhibitor (2Z)-2-(3H-1,3-b... 1 0
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Transient receptor potential cation channel subfamily V member... 18 1
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 3
Dihydrofolate reductase inhibitor 5-[[4-[2-[4-(4-aminophenyl)s... 1 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Nociceptin receptor and Delta-type opioid receptor ligand 2-[3... 2 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
P2X purinoceptor 3 and P2X purinoceptor 2 inhibitor 2-[[4-amin... 10 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Tyrosine-protein kinase receptor Tie-1 and Receptor-type tyros... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 7 4
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 1 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Epidermal growth factor receptor ligand 4-Anilinoquinazoline d... 2 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-07ZH03... 1 0
Metabotropic glutamate receptor 5 ligand N-[2-[(3-chlorophenyl... 1 4
Receptor-type tyrosine-protein kinase FLT3 and Non-receptor ty... 3 3
Dihydrofolate reductase inhibitor 5-[3-(3-methoxy-5-morpholin-... 2 0
Fatty-acid amide hydrolase 1 inhibitor bisarylimidazole deriva... 1 1
Glucokinase inhibitor 4-methyl-N-[3-phenylmethoxy-5-(pyridin-2... 1 8
Protein kinase C theta type inhibitor SureCN3953579 family 2 1
Corticotropin-releasing factor receptor 1 ligand N-[(1R,2S)-2-... 3 0
Alpha-1A adrenergic receptor and D(2) dopamine receptor ligand... 2 5
Multidrug resistance-associated protein 1 inhibitor SureCN6823... 1 0
Coagulation factor X and Cationic trypsin inhibitor 1qb6 family 4 15
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-073... 1 1
Nuclear receptor ROR-gamma and Cytochrome P450 3A4 ligand NCGC... 1 1
TGF-beta receptor type-1 ligand 2wou family 1 0
Vascular endothelial growth factor receptor 2 and Serine/threo... 4 2
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 3 35
Huntingtin and Nuclear receptor ROR-gamma ligand CHEMBL1324975... 1 0
Sodium channel protein type 9 subunit alpha and Sodium channel... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00168063 CHEMBL2035049 Bioactive CHEMBL2035049
CFAMM00168023 CHEMBL2181088 Bioactive CHEMBL2181088
CFAMM00168016 CHEMBL2181312 Bioactive CHEMBL2181312
CFAMM00168084 CHEMBL1946442 Bioactive CHEMBL1946442
CFAMM00167999 DNCL002545 Clinical Trial Drug SB1518
CFAMM00168093 DNCL002191 Clinical Trial Drug TG02

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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