CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD68
Family Name Glycogen synthase kinase-3 beta and Protein kinase C beta type Inhibitor Enzastaurin Family
No. of Seeds 5 No. of Other Members 53
Family Centroid CFAMM00132637 Functional Category Clinical Trial Drug with Natural Product
Superfamily Protein kinase C beta type and Glycogen synthase kinase-3 beta Binder Superfamily
Class Class 840

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... 4 151
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
HIV protease Inhibitor Saquinavir Family 64 428
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Gamma-aminobutyric acid A receptor Ligand Bromazepam Family 2 60
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
Prothrombin Inhibitor Ximelegatran Family 8 157
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Histidine decarboxylase Inhibitor Bf-derm1 Family 12 95
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36
Fibroblast growth factor receptor 1 and Aurora kinase B Inhibi... 4 51
Substance-P receptor Ligand GSK424887 Family 8 184
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
D(4) dopamine receptor Ligand SPI-376 Family 7 84
Substance-P receptor Ligand TAK-637 Family 18 63
Setipiprant family 5 118
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
CP-18770 family 6 27
JAK Inhibitor Momelotinib Family 33 83
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
Cyclin-dependent kinase 5 Inhibitor 9-nitropaullone Family 2 13
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
NF-kappa-B and Protein kinase C zeta type Inhibitor Go6976 Family 9 71
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
C-X-C chemokine receptor type 2 Ligand Sb 272844 Family 7 3
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 5 Inhibi... 2 5
Cyclin-dependent kinase 1 and G2/mitotic-specific cyclin-B1 In... 2 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8
Cannabinoid receptor 2 Ligand JWH-204 Family 6 10
Cannabinoid receptor 2 Ligand JWH-249 Family 7 13
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Platelet-derived growth factor receptor alpha and Platelet-der... 3 3
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Serine/threonine-protein kinase Chk1 Inhibitor BIS-IMIDE A Family 1 3
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Mineralocorticoid receptor and Androgen receptor Ligand WAY-25... 10 26
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 4 33
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Aldose reductase Inhibitor 3-(3-benzoyl-1h-pyrrol-1-yl)propano... 3 7
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Platelet-activating factor receptor ligand A-85783 family 13 62
Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... 1 0
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
C-C chemokine receptor type 5 ligand AC1LAJEM family 4 14
Pol polyprotein inhibitor penicillin deriv. 40 family 2 4
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 3 1
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 1
Cathepsin K inhibitor [(3S)-1-(1H-indole-6-carbonyl)-4,4-dimet... 2 4
Glycogen synthase kinase-3 beta inhibitor AGN-PC-07ZA4D family 1 0
Prolyl endopeptidase inhibitor [(2S,3aS,7aS)-2-(pyrrole-1-carb... 2 0
Histone deacetylase 3 and Histone deacetylase 6 inhibitor Tria... 20 37
Cholecystokinin receptor type A ligand A-65186 family 2 6
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 5 0
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
Cathepsin L1 inhibitor Bio2_000267 family 9 1
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 1 0
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 13
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Disintegrin and metalloproteinase domain-containing protein 17... 2 11
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
Serine/threonine-protein kinase pim-3 and Serine/threonine-pro... 4 6
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Renin inhibitor [(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydrox... 3 1
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 1
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Prelamin-A/C and Pyruvate kinase PKM inhibitor CHEMBL1481187 f... 1 7
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Serine/threonine-protein kinase D3 and Protein kinase C delta ... 3 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Serine/threonine-protein kinase D3 and Protein kinase C delta ... 3 0
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Glycogen synthase kinase-3 beta and Tyrosine-protein kinase JA... 1 0
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Translocator protein inhibitor AGN-PC-08WI0V family 1 0
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Substance-K receptor ligand N-[1-[[(2S)-1-[[1-(oxan-4-ylmethyl... 3 0
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 5 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 0
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Baculoviral IAP repeat-containing protein 2 and Baculoviral IA... 1 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
Protein kinase C beta type and Protein kinase C delta type inh... 1 2
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 1 0
Mitogen-activated protein kinase 9 and MAP kinase-activated pr... 1 0
Glycogen synthase kinase-3 beta inhibitor 3-(2-bromoacetyl)-4-... 1 0
C-X-C chemokine receptor type 3 ligand (6aR,9R)-N-phenyl-4-(2-... 5 0
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 0
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Histamine H3 receptor ligand N-methyl-N-[(3R)-1-propan-2-ylpyr... 3 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family 2 4
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 12
Cytochrome P450 2D6 and Cytochrome P450 2C19 inhibitor Demethy... 1 4
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 7 0
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL1935258 family 7 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 14 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 2 0
Melanin-concentrating hormone receptor 1 ligand N-[(3S)-1-[[(3... 2 0
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Serine/threonine-protein kinase Chk1 inhibitor 3-[5-(piperidin... 1 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 1 1
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Fatty-acid amide hydrolase 1 inhibitor 1-[3-[4-(6-phenylhexyl)... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Motilin receptor ligand SureCN2768052 family 3 0
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
Seprase and Prolyl endopeptidase inhibitor 7-chloro-N-[2-[(2S)... 3 3
Glycogen synthase kinase-3 beta inhibitor 3-(5-bromo-1-methyli... 1 0
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Leucine-rich repeat serine/threonine-protein kinase 2 and Plat... 1 0
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3-fluo... 6 4
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 18
CGMP-dependent protein kinase inhibitor methyl 2-[[4-[5-(4-flu... 6 1
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 1
Hepatocyte growth factor receptor and Protein-tyrosine kinase ... 2 15
Proteinase-activated receptor 1 and Prothrombin ligand (2S)-N-... 3 23
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Protein kinase C alpha type and Protein kinase C delta type in... 2 0
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Tyrosine-protein kinase Yes and Proto-oncogene tyrosine-protei... 7 18
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 1
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Cyclin-dependent kinase 2 inhibitor SureCN6589205 family 2 2
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
Stromelysin-3 and Neutrophil collagenase inhibitor AGN-PC-074N... 3 1
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Histone deacetylase 1 inhibitor AGN-PC-0456JP family 1 0
Gonadotropin-releasing hormone receptor ligand methyl 4-[2-[[(... 2 1
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 5 2
Chymase inhibitor SureCN408571 family 1 3
Angiopoietin-1 receptor and Vascular endothelial growth factor... 1 0
KiSS-1 receptor ligand SureCN5132924 family 2 4
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
72 kDa type IV collagenase and Interstitial collagenase inhibi... 1 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
Cytochrome P450 2C9 inhibitor AGN-PC-04XDND family 1 3
Translocator protein inhibitor N,N-dibutyl-2-(7-chloro-2-pheny... 3 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 2 0
Heat shock protein HSP 90-alpha inhibitor CHEMBL1760611 family 19 25
Androgen receptor ligand CHEMBL181722 family 1 1
Methionine aminopeptidase 1 inhibitor ethyl 4-[4-(2-pyridin-2-... 2 3
Serine/threonine-protein kinase Chk1 inhibitor SureCN6080935 f... 1 0
Metabotropic glutamate receptor 5 ligand 3-methyl-1-[2-[3-(tri... 3 1
Receptor-interacting serine/threonine-protein kinase 1 ligand ... 1 11
Peptide deformylase and Peptide deformylase 1A, chloroplastic/... 1 1
Coagulation factor X inhibitor (3R,4R)-3-N-[2-fluoro-4-(2-oxop... 1 0
Protein-glutamine gamma-glutamyltransferase 2 inhibitor SureCN... 2 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 0
Arachidonate 5-lipoxygenase inhibitor 1-[1-(4-methylphenyl)sul... 1 0
Prostaglandin D2 receptor 2 ligand AGN-PC-00QBAU family 1 24
Histone deacetylase 1 inhibitor N-[(2S)-1,8-dioxo-1-[2-(2-phen... 2 0
Tyrosine-protein kinase JAK3 inhibitor (3Z)-5-pyridin-3-yl-3-(... 1 0
Cyclin-dependent kinase 2 inhibitor pyrrollylactam indolinone ... 1 0
Proto-oncogene Wnt-3 inhibitor CHEMBL563202 family 2 0
2,3,6,7-tetrahydropyrazino[1',2':1,2]pyrido[3,4-b]indole-1,4(1... 3 0
9H-pyrido[3,4-b]indole-3-carboxamide NP (1-(3-bromophenyl)-9h-... 5 0
NP 2-(4-bromo-1h-indol-1-yl)-n-(1h-indol-6-yl)acetamide Family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00132657 DCL000366 Clinical Trial Drug Ro 31-7453
CFAMM00132637 DCL000109 Clinical Trial Drug Enzastaurin
CFAMM00132642 DCL000970 Clinical Trial Drug Ruboxistaurin

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21783 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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