CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD681
Family Name SB989 family
No. of Seeds 17 No. of Other Members 91
Family Centroid CFAMM00168338 Functional Category Clinical Trial Drug
Superfamily SB989 Superfamily
Class Class 561

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Tubulin beta chain Inhibitor Mebendazole Family 12 84
Histamine H1 receptor Ligand Mizolastine Family 14 603
Prothrombin Inhibitor Dabigatran Family 7 182
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Translocator protein Inhibitor Emapunil Family 7 89
HCV NS4B protein Inhibitor Clemizole Family 2 43
BIBT986 family 7 96
CC-486 family 7 103
Tryptase Inhibitor Babim Family 12 90
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Cathepsin D Inhibitor 1h-benoximidazole-2-carboxylic Acid Family 1 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Vascular endothelial growth factor receptor 2 Ligand 6-(1h-ben... 2 5
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Aromatase Inhibitor NSC-356781 Family 3 10
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Farnesyl pyrophosphate synthase Inhibitor [2-(benzoimidazol-1-... 2 16
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 3
Acetylcholinesterase inhibitor SureCN251059 family 2 16
Histone deacetylase 1 and Histone deacetylase 8 inhibitor (E)-... 3 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 0
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 3
Histamine H4 receptor ligand SureCN602132 family 1 8
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Adenosine receptor A2a ligand AGN-PC-01LVXW family 2 25
Adenosine receptor A2a ligand SureCN14156209 family 3 2
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27
Vascular endothelial growth factor receptor 2 and Mitogen-acti... 2 2
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
Nociceptin receptor and Kappa-type opioid receptor ligand 1-[1... 4 4
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 1
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Coagulation factor X and Trypsin-1 inhibitor 1-(3-carbamimidoy... 4 1
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Transient receptor potential M8 protein ligand 2-[(E)-2-(oxan-... 5 3
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Bile acid receptor and Potassium voltage-gated channel subfami... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 18
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 5 13
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 14
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
C-C chemokine receptor type 5 ligand [4-[2-[3-(2-ethylbenzimid... 5 12
Cannabinoid receptor 1 ligand SureCN675796 family 5 1
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(1H-pyr... 2 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Histamine H3 receptor ligand SureCN2878688 family 8 1
Progesterone receptor ligand AGN-PC-00B9AT family 4 4
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Histamine H1 receptor and Potassium voltage-gated channel subf... 1 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-0733AC family 7 29
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 1
Neuropeptide Y receptor type 5 ligand 2-(3-phenylpiperidin-1-y... 6 2
Cdc2-related kinase inhibitor N-[6-(3,5-dimethylphenyl)-1-meth... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 2 1
Urokinase plasminogen activator surface receptor ligand ethyl ... 1 0
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Melanocortin receptor 4 ligand AGN-PC-076AMT family 2 9
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Orexin receptor type 2 and Orexin receptor type 1 ligand (2R)-... 12 16
Melanin-concentrating hormone receptor 1 and Potassium voltage... 4 4
Fatty acid-binding protein, adipocyte inhibitor AGN-PC-02W5KO ... 2 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Disintegrin and metalloproteinase domain-containing protein 17... 3 0
Disintegrin and metalloproteinase domain-containing protein 17... 10 4
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 22
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 11 5
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 3
Type-1 angiotensin II receptor ligand SureCN7390271 family 2 1
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Putative Bioactive N-[(2R)-2-[(2S)-2-(1H-benzimidazol-2-yl)pyr... 2 0
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... 3 3
Gonadotropin-releasing hormone receptor and 5-hydroxytryptamin... 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Dipeptidyl peptidase 4 inhibitor SureCN5776796 family 1 0
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 1 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Neuropeptide Y receptor type 5 ligand SureCN8149543 family 1 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Inosine-5'-monophosphate dehydrogenase inhibitor N-(4-chloroph... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00168304 CHEMBL1099057 Bioactive (E)-N-hydroxy-3-[3-[1-(2-piperidin-1-ylethyl)benzimidazol-2-yl]phenyl]prop-2-enamide
CFAMM00168287 CHEMBL1830536 Bioactive (E)-3-[1-[2-(ethylamino)ethyl]-2-[(Z)-hex-3-enyl]benzimidazol-5-yl]-N-hydroxyprop-2-enamide
CFAMM00168317 CHEMBL1830397 Bioactive (E)-3-[1-[3-(dimethylamino)-2,2-dimethylpropyl]-2-(2,2-dimethylpropyl)benzimidazol-5-yl]-N-hydroxyprop-2-enamide
CFAMM00168279 CHEMBL1095451 Bioactive (E)-N-hydroxy-3-[3-[5-methyl-4-phenyl-1-(2-phenylethyl)imidazol-2-yl]phenyl]prop-2-enamide
CFAMM00168301 CHEMBL1830420 Bioactive (E)-3-[1-[2-(ethylamino)ethyl]-2-hexylbenzimidazol-5-yl]-N-hydroxyprop-2-enamide
CFAMM00168341 CHEMBL1099096 Bioactive (E)-N-hydroxy-3-[3-[1-(2-phenylethyl)benzimidazol-2-yl]phenyl]prop-2-enamide
CFAMM00168305 CHEMBL1830424 Bioactive (E)-3-[1-[2-(dimethylamino)ethyl]-2-hexylbenzimidazol-5-yl]-N-hydroxyprop-2-enamide
CFAMM00168368 CHEMBL1096433 Bioactive (E)-N-hydroxy-3-[3-[4-methyl-5-phenyl-1-(2-phenylethyl)imidazol-2-yl]phenyl]prop-2-enamide
CFAMM00168338 DNCL002275 Clinical Trial Drug SB989
CFAMM00168349 DPR000154 Investigative Drug SB-639
CFAMM00168348 DPR000152 Investigative Drug SB-623

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26197 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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