CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFCD689
Family Name Hepatocyte growth factor receptor Ligand Amg 208 Family
No. of Seeds 20 No. of Other Members 236
Family Centroid CFAMM00168575 Functional Category Clinical Trial Drug with Natural Product
Superfamily Hepatocyte growth factor receptor Ligand Amg 208 Superfamily
Class Class 1248

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Histamine H1 receptor Ligand Astemizole Family 7 240
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Mitogen-activated protein kinase 12 Inhibitor Birb 796 Family 20 43
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Corticotropin-releasing factor receptor 1 Ligand GSK561679 Family 5 6
Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Family 24 11
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
AP26113 family 16 90
SB1518 family 7 103
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Ibrutinib family 2 27
PF-02545920 family 16 140
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 37
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Mitogen-activated protein kinase 14 Inhibitor CP-808844 Family 39 43
Platelet-derived growth factor receptor beta and Ephrin type-B... 9 16
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16
Oxytocin receptor and Vasopressin V1a receptor Ligand PF-32741... 4 36
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
AMP-activated protein kinase Inhibitor 4-(3-bromopyrazolo[1,5-... 1 8
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Dual specificity mitogen-activated protein kinase kinase 1 inh... 10 54
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Xanthine dehydrogenase/oxidase inhibitor AGN-PC-00KCTP family 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YMN ... 7 11
Serine/threonine-protein kinase B-raf inhibitor SureCN1013580 ... 2 0
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YXQ ... 2 1
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 8 1
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 1
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 5
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CC4... 20 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 6
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Cathepsin S and Cathepsin K inhibitor AGN-PC-07YOWS family 4 6
Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family 3 11
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Epidermal growth factor receptor and Cyclin-dependent kinase 1... 3 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 10 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 10 54
Proto-oncogene tyrosine-protein kinase Src and Phosphatidylino... 4 20
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 3 6
Adenosine receptor A3 and Adenosine receptor A2a ligand 4-(5-b... 2 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Tyrosine-protein kinase ABL1 and Tyrosine-protein kinase HCK i... 2 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 12 8
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threon... 1 1
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Translocator protein inhibitor AGN-PC-080ILF family 9 3
Aurora kinase A inhibitor AGN-PC-00BCUF family 16 43
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 5
Leukotriene B4 receptor 1 ligand AGN-PC-075N6M family 2 4
Survival motor neuron protein inhibitor CHEMBL1379159 family 1 10
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 3 0
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 4
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Epidermal growth factor receptor ligand Pyrimido[4,5-b]indole ... 1 4
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
Neuropeptide Y receptor type 1 ligand 1-[3-[1-(cyclohexylmethy... 15 9
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15681... 1 5
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Adenosine receptor A2a ligand 2-(furan-2-yl)-7-[3-[(4-phenylpi... 11 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 3 4
Mitogen-activated protein kinase 10 and Transcription factor A... 1 1
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Sodium/glucose cotransporter 2 inhibitor AGN-PC-0A9TPG family 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 6 0
Voltage-dependent calcium channel subunit alpha-2/delta-1 and ... 9 15
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 5
Dihydrofolate reductase inhibitor 7-(2-ethoxynaphthalen-1-yl)-... 3 2
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
Corticotropin-releasing factor receptor 1 ligand CHEMBL1819076... 2 0
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 0
Hepatocyte growth factor receptor ligand 4-[(6-phenyl-[1,2,4]t... 3 6
Corticotropin-releasing factor receptor 1 ligand 5-N-(2-chloro... 7 1
Sigma non-opioid intracellular receptor 1 ligand 6-methoxy-1'-... 2 0
Corticotropin-releasing factor receptor 1 ligand CHEMBL1830528... 1 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 2
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 1 0
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 3
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 17
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
Metabotropic glutamate receptor 5 ligand SureCN4699900 family 1 5
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 5 8
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 4 4
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Mitogen-activated protein kinase 14 inhibitor 1-[5-tert-butyl-... 3 2
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 7 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
Fibroblast growth factor receptor 1 and Vascular endothelial g... 3 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand Piper... 3 14
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 1-... 8 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-[2-... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Estrogen receptor and Estrogen receptor beta ligand 4-[3-[4-(2... 1 0
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Glucose-dependent insulinotropic receptor ligand (2R)-2-[1-(5-... 4 0
Glucose-dependent insulinotropic receptor ligand 2-[1-(5-ethyl... 2 1
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Metabotropic glutamate receptor 2 ligand 8-chloro-3-(cycloprop... 6 2
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Adenosine receptor A2a and Adenosine receptor A1 ligand 5-[(7S... 6 1
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Acyl-CoA desaturase 1 inhibitor 3-[4-(2-chlorophenoxy)piperidi... 1 0
Transient receptor potential cation channel subfamily V member... 2 4
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 2
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 0
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 1 2
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 12 2
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 4 9
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Mitogen-activated protein kinase 1 inhibitor 1-[(3R)-1-[(2-flu... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Tyrosine-protein kinase JAK2 inhibitor 4-[[8-(4-methoxyphenyl)... 2 1
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dih... 1 5
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Substance-P receptor ligand (2S,3S)-N-[[2-methoxy-5-(tetrazol-... 2 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN4806204 f... 13 7
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN4817112 f... 2 0
Serine/threonine-protein kinase Chk1 and Aurora kinase B inhib... 14 0
Melanin-concentrating hormone receptor 1 ligand SureCN5431614 ... 1 2
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 14 3
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 0
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Receptor tyrosine-protein kinase erbB-2 ligand SureCN3374869 f... 4 8
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 4-[4-... 1 0
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 7 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 4 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 3
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Tubulin beta-4A chain and Tubulin beta-2B chain inhibitor AGN-... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Type-1 angiotensin II receptor ligand AGN-PC-00FH82 family 1 1
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 4
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN136... 1 0
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Tyrosine-protein kinase SYK and Lysine--tRNA ligase inhibitor ... 8 8
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 1
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
B2 bradykinin receptor ligand SureCN13145573 family 7 6
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Aurora kinase A and Glycogen synthase kinase-3 beta inhibitor ... 1 2
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Hepatocyte growth factor receptor and Potassium voltage-gated ... 1 0
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-07CQG5 ... 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Glucokinase inhibitor AGN-PC-03ZE5E family 1 0
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Tyrosine-protein kinase Lck inhibitor AGN-PC-07R5ZB family 4 3
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor AGN-PC... 2 0
Acyl-CoA desaturase 1 inhibitor Pyridazine, 3-[4-(2-ethylpheno... 4 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D inhibitor Sure... 2 6
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Voltage-dependent calcium channel subunit alpha-2/delta-1 liga... 1 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Receptor tyrosine-protein kinase erbB-2 and Insulin-like growt... 4 2
Serine/threonine-protein kinase PLK1 inhibitor SureCN3992071 f... 1 0
Casein kinase II subunit alpha inhibitor N-[3-[[8-cyano-4-(3-e... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00168724 CHEMBL494630 Bioactive Triazolopyridazine, 10e
CFAMM00168702 CHEMBL563200 Bioactive AGN-PC-046RZP
CFAMM00168723 CHEMBL53238 Bioactive SureCN2653006
CFAMM00168632 CHEMBL494979 Bioactive Triazolopyridazine, 10f
CFAMM00168701 CHEMBL224134 Bioactive SureCN340810
CFAMM00168652 CHEMBL2032039 Bioactive 7-methoxy-4-[[6-(3,4,5-trifluorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methoxy]quinoline
CFAMM00168687 CHEMBL567908 Bioactive Triazolopyridazine, 10m
CFAMM00168673 CHEMBL298386 Bioactive AGN-PC-0095DP
CFAMM00168637 CHEMBL1823125 Bioactive Triazolopyridazine, 10g
CFAMM00168715 CHEMBL300497 Bioactive 6-[(5-methylpyridin-2-yl)methoxy]-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazine
CFAMM00168644 CHEMBL522196 Bioactive Triazolopyridazine, 10d
CFAMM00168742 CHEMBL50402 Bioactive AGN-PC-008X4N
CFAMM00168650 CHEMBL2431823 Bioactive 6-[(1S)-1-[6-(3-fluoro-4-methoxyphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl]quinoline
CFAMM00168705 CHEMBL494793 Bioactive Triazolopyridazine, 10b
CFAMM00168671 CHEMBL469053 Bioactive AGN-PC-072WNG
CFAMM00168649 CHEMBL2431824 Bioactive 6-[(1S)-1-[6-(4-methoxy-3-methylphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl]quinoline
CFAMM00168789 CHEMBL303321 Bioactive pyrazolopyrimidine derivative 44
CFAMM00168575 DNCL002363 Clinical Trial Drug AMG 208

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45918 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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