CFAM

Seed Molecules
Non-seed Members

CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00168869 CHEMBL1938510 Bioactive (2S,3S)-2-[(2-amino-2-methylpropanoyl)amino]-N-[(4-chlorophenyl)-pyridin-4-ylmethyl]-3-(4-phenylphenyl)butanamide
CFAMM00168883 CHEMBL1938509 Bioactive (2S,3S)-2-amino-N-[(4-chlorophenyl)-pyridin-4-ylmethyl]-3-(4-phenylphenyl)butanamide
CFAMM00168820 CHEMBL1938523 Bioactive N-[1-(4-chlorophenyl)-1-pyridin-4-ylethyl]-3-(4-phenylpiperidin-1-yl)propanamide
CFAMM00168819 CHEMBL1938522 Bioactive N-[(4-chlorophenyl)-pyridin-4-ylmethyl]-3-(4-phenylpiperidin-1-yl)propanamide
CFAMM00168839 DNCL002381 Clinical Trial Drug ABC294640

CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00168843 CHEMBL1288528 Bioactive SureCN12999172
CFAMM00168848 CHEMBL466874 Bioactive N-[(1R,5R)-8-[bis(2-chlorophenyl)methyl]-3-pyridin-2-yl-8-azabicyclo[3.2.1]octan-3-yl]acetamide
CFAMM00168861 CHEMBL508750 Bioactive N-[[(1S,5S)-8-[bis(2-chlorophenyl)methyl]-3-pyridin-2-yl-8-azabicyclo[3.2.1]octan-3-yl]methyl]acetamide
CFAMM00168875 CHEMBL513317 Bioactive (1R,5R)-8-[bis(2-chlorophenyl)methyl]-3-pyridin-3-yl-8-azabicyclo[3.2.1]octane-3-carboxamide
CFAMM00168859 CHEMBL467493 Bioactive N-[(1R,5R)-8-[bis(2-chlorophenyl)methyl]-3-(5-fluoropyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-yl]acetamide
CFAMM00168817 CHEMBL1823661 Bioactive N-[(R)-(1-benzylpiperidin-4-yl)-(3,4-dichlorophenyl)methyl]isoquinoline-6-carboxamide
CFAMM00168887 CHEMBL2179848 Bioactive 2,4-dichloro-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]benzamide
CFAMM00168864 CHEMBL1823637 Bioactive N-[(4-chloro-3-phenylphenyl)-piperidin-4-ylmethyl]isoquinoline-6-carboxamide
CFAMM00168894 CHEMBL2371493 Bioactive CHEMBL2371493
CFAMM00168857 CHEMBL318127 Bioactive (2R)-1-[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-2-ylpropanoyl]amino]-6-aminohexanoyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00168822 CHEMBL452423 Bioactive SureCN2008516
CFAMM00168885 CHEMBL1287814 Bioactive N-[3-chloro-4-(4-piperidin-1-ylpiperidin-1-yl)phenyl]-2-phenyl-2-pyridin-2-ylacetamide
CFAMM00168893 CHEMBL248028 Bioactive [(3R,4S)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidin-3-yl]-[4-[1-[(2-pyridin-2-ylethylamino)methyl]cyclohexyl]piperazin-1-yl]methanone
CFAMM00168821 CHEMBL408737 Bioactive (2R)-1-[(2R)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-2-ylpropanoyl]amino]propanoyl]amino]-6-(propan-2-ylamino)hexanoyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00168884 CHEMBL273565 Bioactive [(3R,4S)-1-benzyl-4-(4-chlorophenyl)pyrrolidin-3-yl]-[4-[1-[(pyridin-4-ylmethylamino)methyl]cyclohexyl]piperazin-1-yl]methanone
CFAMM00168841 CHEMBL461331 Bioactive N-[[(1S,5S)-8-[bis(2-chlorophenyl)methyl]-3-(3-methylpyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-yl]methyl]acetamide
CFAMM00168840 CHEMBL197541 Bioactive 2-amino-N-[(2R)-3-(4-chlorophenyl)-1-oxo-1-[4-[1-[[(2-phenylacetyl)amino]methyl]cyclohexyl]piperazin-1-yl]propan-2-yl]-3-pyridin-4-ylpropanamide
CFAMM00168825 CHEMBL329807 Bioactive (2R)-1-[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-2-ylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00168881 CHEMBL1823640 Bioactive N-[(4-chlorophenyl)-piperidin-4-ylmethyl]isoquinoline-6-carboxamide
CFAMM00168832 CHEMBL400870 Bioactive [(3R,4S)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidin-3-yl]-[4-[1-[[methyl(pyridin-4-ylmethyl)amino]methyl]cyclohexyl]piperazin-1-yl]methanone
CFAMM00168896 CHEMBL1823652 Bioactive 3-chloro-N-[(3,4-dichlorophenyl)-piperidin-4-ylmethyl]isoquinoline-6-carboxamide
CFAMM00168845 CHEMBL508160 Bioactive N-[[(1S,5S)-8-[bis(2-chlorophenyl)methyl]-3-[3-(piperidin-1-ylmethyl)pyridin-2-yl]-8-azabicyclo[3.2.1]octan-3-yl]methyl]acetamide
CFAMM00168838 CHEMBL428186 Bioactive (2R)-1-[(2R)-2-[[2-[[(2R)-2-[[(2R)-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-2-ylpropanoyl]-methylamino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00168851 CHEMBL181297 Bioactive (2S)-N-methyl-2-[(3S)-3-(2-methylpropyl)-2,5-dioxo-4-[(E)-3-pyridin-4-ylprop-2-enyl]-1,4-diazepan-1-yl]-3-naphthalen-2-ylpropanamide
CFAMM00168866 CHEMBL1823653 Bioactive N-[(3,4-dichlorophenyl)-piperidin-3-ylmethyl]isoquinoline-6-carboxamide
CFAMM00168880 CHEMBL2371488 Bioactive CHEMBL2371488
CFAMM00168831 CHEMBL406243 Bioactive (2R)-1-[(2R)-2-[[1-[[(2R)-2-[[(2R)-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-2-ylpropanoyl]amino]cyclobutanecarbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00168844 CHEMBL216930 Bioactive (2S)-1-[(2S,5S,8S,11S,14S,17S,20S,29S)-29-acetamido-2-[(4-chlorophenyl)methyl]-11-[3-(diaminomethylideneamino)propyl]-8-methyl-17-(2-methylpropyl)-14-(naphthalen-2-ylmethyl)-3,6,9,12,15,18,26,30-octaoxo-5-(pyridin-3-ylmethyl)-1,4,7,10,13,16,19,25-octazacyclotriacontane-20-carbonyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00168895 CHEMBL439439 Bioactive CHEMBL439439
CFAMM00168872 CHEMBL372576 Bioactive N-[(2R)-3-(4-chlorophenyl)-1-oxo-1-[4-[1-[[(2-phenylacetyl)amino]methyl]cyclohexyl]piperazin-1-yl]propan-2-yl]pyridine-3-carboxamide
CFAMM00168901 CHEMBL2370262 Bioactive (2S)-1-[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-2-ylpropanoyl]amino]propanoyl]amino]hexanoyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00168823 CHEMBL247636 Bioactive [(3R,4S)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidin-3-yl]-[4-[1-[(pyridin-2-ylmethylamino)methyl]cyclohexyl]piperazin-1-yl]methanone
CFAMM00168850 CHEMBL397607 Bioactive [(3R,4S)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidin-3-yl]-[4-[1-[(pyridin-3-ylmethylamino)methyl]cyclohexyl]piperazin-1-yl]methanone
CFAMM00168837 CHEMBL361985 Bioactive 2-amino-N-[(2R)-3-(4-chlorophenyl)-1-oxo-1-[4-[2-[1-(piperidin-3-ylamino)ethyl]phenyl]piperazin-1-yl]propan-2-yl]-3-pyridin-3-ylpropanamide
CFAMM00168878 CHEMBL2370256 Bioactive (2S)-1-[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-2-ylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(carbamoylamino)pentanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00168830 CHEMBL415608 Bioactive (2S)-1-[(2S,5S,8S,11S,14S,17S,20S,29R)-29-acetamido-2-[(4-chlorophenyl)methyl]-11-[3-(diaminomethylideneamino)propyl]-8-methyl-17-(2-methylpropyl)-14-(naphthalen-2-ylmethyl)-3,6,9,12,15,18,26,30-octaoxo-5-(pyridin-3-ylmethyl)-1,4,7,10,13,16,19,25-octazacyclotriacontane-20-carbonyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00168871 CHEMBL182231 Bioactive (3R)-N-[(2R)-3-(4-chlorophenyl)-1-[4-[2-[[methyl(pyridin-3-ylmethyl)amino]methyl]phenyl]piperazin-1-yl]-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
CFAMM00168900 CHEMBL2370265 Bioactive (2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-2-ylpropanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00168836 CHEMBL96693 Bioactive (2R)-1-[(2R)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-2-ylpropanoyl]amino]propanoyl]amino]-6-aminohexanoyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00168849 CHEMBL397608 Bioactive [(3R,4S)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidin-3-yl]-[4-[1-[(pyridin-4-ylmethylamino)methyl]cyclohexyl]piperazin-1-yl]methanone
CFAMM00168863 CHEMBL1823638 Bioactive N-[(4-chloro-3-cyanophenyl)-piperidin-4-ylmethyl]isoquinoline-6-carboxamide
CFAMM00168829 CHEMBL265825 Bioactive CHEMBL265825
CFAMM00168842 CHEMBL97540 Bioactive (2R)-1-[(2S)-2-[[2-[[(2R)-2-[[(2R)-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-2-ylpropanoyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00168835 CHEMBL2312961 Bioactive CHEMBL2312961
CFAMM00168899 CHEMBL261927 Bioactive (2R)-1-[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-2-ylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00168862 CHEMBL1823639 Bioactive N-[(3-chlorophenyl)-piperidin-4-ylmethyl]isoquinoline-6-carboxamide
CFAMM00168892 CHEMBL32451 Bioactive SureCN8007464
CFAMM00168828 CHEMBL94842 Bioactive (2R)-1-[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-2-ylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00168854 CHEMBL267986 Bioactive (2R)-1-[(2R)-2-[3-[[(2R)-2-[[(2R)-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-2-ylpropanoyl]amino]propanoylamino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00168834 CHEMBL551924 Bioactive AGN-PC-07C62Y
CFAMM00168898 CHEMBL105101 Bioactive T6220718
CFAMM00168847 CHEMBL185583 Bioactive (3R)-N-[(2R)-3-(4-chlorophenyl)-1-[4-[2-[[methyl(2-pyridin-2-ylethyl)amino]methyl]phenyl]piperazin-1-yl]-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
CFAMM00168890 CHEMBL2179841 Bioactive 3-chloro-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]benzamide
CFAMM00168853 CHEMBL385022 Bioactive (2R)-1-[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-2-ylpropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00168882 CHEMBL1823641 Bioactive N-[(4-chloro-3-fluorophenyl)-piperidin-4-ylmethyl]isoquinoline-6-carboxamide
CFAMM00168868 CHEMBL1938511 Bioactive (2S,3S)-2-amino-N-[(4-chlorophenyl)-(2-methylpyridin-4-yl)methyl]-3-(4-phenylphenyl)butanamide
CFAMM00168897 CHEMBL268720 Bioactive (2R)-1-[(2R)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-2-ylpropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00168846 CHEMBL181788 Bioactive 2-amino-N-[(2R)-3-(4-chlorophenyl)-1-oxo-1-[4-[2-[1-(piperidin-3-ylamino)ethyl]phenyl]piperazin-1-yl]propan-2-yl]-3-pyridin-2-ylpropanamide
CFAMM00168860 CHEMBL52615 Bioactive (2E)-5,5-bis(4-chlorophenyl)-N-(4-pyridin-3-ylbutyl)penta-2,4-dienamide
CFAMM00168874 CHEMBL183610 Bioactive (3R)-N-[(2R)-3-(4-chlorophenyl)-1-oxo-1-[4-[2-[(pyridin-4-ylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
CFAMM00168889 CHEMBL2179842 Bioactive 4-chloro-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]benzamide
CFAMM00168852 CHEMBL512895 Bioactive (2S,3S)-2-amino-3-[4-(3-chloropyridin-4-yl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one
CFAMM00168867 CHEMBL1823643 Bioactive N-[(3,4-dichlorophenyl)-piperidin-4-ylmethyl]isoquinoline-6-carboxamide
CFAMM00168818 CHEMBL1938525 Bioactive N-[(4-chlorophenyl)-(2,6-dimethylpyridin-4-yl)methyl]-3-(4-phenylpiperidin-1-yl)propanamide
CFAMM00168873 CHEMBL327359 Bioactive (2R)-1-[2-[[(2R)-2-[[(2R)-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-2-ylpropanoyl]amino]acetyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00168824 CHEMBL428619 Bioactive (2R)-1-[(2R)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-2-ylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00168888 CHEMBL53149 Bioactive (2E)-5,5-bis(3-chlorophenyl)-N-(4-pyridin-3-ylbutyl)penta-2,4-dienamide
CFAMM00168902 CHEMBL2370263 Bioactive (2S)-1-[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-2-ylpropanoyl]amino]propanoyl]amino]-5-(carbamoylamino)pentanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00168877 ZINC03999740 Natural Product (E)-3-(4-chlorophenyl)-N-[(2S)-2-pyridin-3-ylpiperidine-1-carbothioyl]prop-2-enamide
CFAMM00168876 ZINC03999741 Natural Product (E)-3-(4-chlorophenyl)-N-(2-(pyridin-3-yl)piperidine-1-carbonothioyl)acrylamide
CFAMM00168858 54305660 Patent Compound
CFAMM00168856 23040626 Patent Compound AGN-PC-03YCUW
CFAMM00168870 53748188 Patent Compound
CFAMM00168827 57309695 Patent Compound AGN-PC-0BR03E
CFAMM00168833 57230985 Patent Compound AGN-PC-0BPYIY

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

Last update by

2014.08.29