CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD693
Family Name Aurora kinase A Inhibitor ABT-348 Family
No. of Seeds 20 No. of Other Members 49
Family Centroid CFAMM00168932 Functional Category Clinical Trial Drug
Superfamily Aurora kinase A Inhibitor ABT-348 Superfamily
Class Class 1250

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
PF-4217903 family 14 65
PF-3758309 family 1 8
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
5-hydroxytryptamine receptor Ligand Sl65.0472 Family 2 16
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Vascular endothelial growth factor receptor 2 Ligand 3-(4-amin... 2 5
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Prothrombin and Histone-lysine N-methyltransferase 2A inhibito... 1 7
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Vascular endothelial growth factor receptor 2 and Mast/stem ce... 10 27
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 3
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 8 1
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 1 11
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 2 18
Metabotropic glutamate receptor 4 and Potassium voltage-gated ... 2 15
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 20
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 2
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 2
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 1
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 3
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
3-phosphoinositide-dependent protein kinase 1 and MAP kinase-a... 1 5
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 12 7
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 1
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Aurora kinase A and Aurora kinase B inhibitor 4-amino-N-[4-(th... 1 1
Vascular endothelial growth factor receptor 2 and Vascular end... 4 1
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 5 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Protein-cysteine N-palmitoyltransferase porcupine inhibitor 2-... 5 2
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Glucocorticoid receptor ligand (3R)-3-[1-(4-fluorophenyl)indaz... 4 2
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 16 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Transient receptor potential cation channel subfamily V member... 1 0
Epidermal growth factor receptor and Vascular endothelial grow... 2 1
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Epidermal growth factor receptor and Vascular endothelial grow... 3 1
Vascular endothelial growth factor receptor 2 ligand Thienopyr... 2 2
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 1 0
Aurora kinase B and Aurora kinase A inhibitor 1-cyclohexyl-3-[... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00168924 CHEMBL2022850 Bioactive 3-[[4-[4-amino-7-(1-methylpyrazol-4-yl)thieno[3,2-c]pyridin-3-yl]phenyl]carbamoylamino]benzamide
CFAMM00168921 CHEMBL2022855 Bioactive 1-[4-[4-amino-7-[1-(1-methyl-2-oxopyrrolidin-3-yl)pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl]phenyl]-3-(3-fluorophenyl)urea
CFAMM00168920 CHEMBL2022856 Bioactive 1-[4-[4-amino-7-[1-[(2R)-2-hydroxypropyl]pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl]phenyl]-3-(3-fluorophenyl)urea
CFAMM00168960 CHEMBL2022857 Bioactive 1-[4-[4-amino-7-[1-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propyl]pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl]phenyl]-3-(3-fluorophenyl)urea
CFAMM00168904 CHEMBL2062935 Bioactive 1-[4-[4-amino-7-[1-[(2R)-2-hydroxypropyl]pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl]phenyl]-3-(3-methylphenyl)urea
CFAMM00168916 CHEMBL2023229 Bioactive 1-[4-[4-amino-7-(1-methylpyrazol-4-yl)thieno[3,2-c]pyridin-3-yl]phenyl]-3-(4-chlorophenyl)urea
CFAMM00168909 CHEMBL2023224 Bioactive 1-[4-[4-amino-7-(1H-pyrazol-5-yl)thieno[3,2-c]pyridin-3-yl]phenyl]-3-(3-methylphenyl)urea
CFAMM00168936 CHEMBL1967720 Bioactive 2-[4-[4-amino-3-[4-[(3-fluorophenyl)carbamoylamino]phenyl]thieno[3,2-c]pyridin-7-yl]pyrazol-1-yl]-2-methylpropanamide
CFAMM00168967 CHEMBL1982466 Bioactive 1-[4-[4-amino-7-(1-methylpyrazol-4-yl)thieno[3,2-c]pyridin-3-yl]phenyl]-3-(4-methylphenyl)urea
CFAMM00168908 CHEMBL2023225 Bioactive 1-[4-[4-amino-7-(1-methylpyrazol-4-yl)thieno[3,2-c]pyridin-3-yl]phenyl]-3-(2-methylphenyl)urea
CFAMM00168923 CHEMBL2022853 Bioactive 1-[4-[4-amino-7-[1-(2-methylsulfonylethyl)pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl]phenyl]-3-(3-fluorophenyl)urea
CFAMM00168965 CHEMBL1969102 Bioactive 1-[4-[4-amino-7-(1H-pyrazol-4-yl)thieno[3,2-c]pyridin-3-yl]phenyl]-3-(3-methylphenyl)urea
CFAMM00168907 CHEMBL2023226 Bioactive 1-[4-[4-amino-7-(1-methylpyrazol-4-yl)thieno[3,2-c]pyridin-3-yl]phenyl]-3-phenylurea
CFAMM00168922 CHEMBL2022854 Bioactive 1-[4-[4-amino-7-[1-(2-piperidin-1-ylethyl)pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl]phenyl]-3-(3-fluorophenyl)urea
CFAMM00168932 DNCL002384 Clinical Trial Drug ABT-348

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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