CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD698
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform and Serine/threonine-protein kinase mTOR Inhibitor PF-04691502 Family
No. of Seeds 11 No. of Other Members 10
Family Centroid CFAMM00169037 Functional Category Clinical Trial Drug
Superfamily Serine/threonine-protein kinase mTOR and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Binder Superfamily 2
Class Class 850

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Smoothened homolog Inhibitor LDE225 Family 3 76
AP26113 family 16 90
SB1518 family 7 103
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Hepatocyte growth factor receptor Ligand BMS-777607 Family 10 1
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Mitogen-activated protein kinase 14 Inhibitor Pamapimod Family 15 7
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2J2 inhib... 1 7
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Serine/threonine-protein kinase mTOR and RAC-alpha serine/thre... 3 3
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 0
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Glycogen synthase kinase-3 beta inhibitor AGN-PC-0802SH family 1 2
Glycogen synthase kinase-3 beta inhibitor 6-[(2S)-2-(2-methoxy... 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 4
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 42 3
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 24 5
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
G-protein coupled bile acid receptor 1 ligand 2-ethyl-6-[3-[4-... 4 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Tyrosine-protein kinase Lck inhibitor SureCN374434 family 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 0
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00169016 CHEMBL2057727 Bioactive 2-amino-8-cyclobutyl-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7-one
CFAMM00169015 CHEMBL2057725 Bioactive 2-amino-8-cyclopentyl-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7-one
CFAMM00169030 CHEMBL2375958 Bioactive 2-[4-[2-amino-6-(6-methoxypyridin-3-yl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]cyclohexyl]oxyacetamide
CFAMM00169013 CHEMBL2376095 Bioactive 2-amino-8-[4-(hydroxymethoxy)cyclohexyl]-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7-one
CFAMM00169012 CHEMBL2376096 Bioactive 2-[4-[2-amino-6-(6-methoxypyridin-3-yl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]cyclohexyl]oxyacetic acid
CFAMM00169046 CHEMBL2375968 Bioactive 2-amino-6-(5-fluoro-6-methoxypyridin-3-yl)-8-[4-(hydroxymethoxy)cyclohexyl]-4-methylpyrido[2,3-d]pyrimidin-7-one
CFAMM00169026 CHEMBL1257177 Bioactive AGN-PC-07PRN8
CFAMM00169056 CHEMBL1258458 Bioactive AGN-PC-09M9UB
CFAMM00169042 CHEMBL2057735 Bioactive 2-amino-6-(6-methoxypyridin-3-yl)-4-methyl-8-pyrrolidin-1-ylpyrido[2,3-d]pyrimidin-7-one
CFAMM00169024 CHEMBL2375957 Bioactive 2-[4-[2-amino-6-(5-fluoro-6-methoxypyridin-3-yl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]cyclohexyl]oxyacetamide
CFAMM00169037 DNCL002403 Clinical Trial Drug PF-04691502

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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