CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD699
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform and Serine/threonine-protein kinase mTOR Inhibitor PF-05212384 Family
No. of Seeds 37 No. of Other Members 10
Family Centroid CFAMM00169074 Functional Category Clinical Trial Drug
Superfamily Serine/threonine-protein kinase mTOR and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Binder Superfamily
Class Class 1233

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Interleukin-12 subunit alpha Inhibitor STA-5326 Family 2 51
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Translocator protein Inhibitor Emapunil Family 7 89
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Serine/threonine-protein kinase mTOR Inhibitor AZD2014 Family 2 41
GDC-0349 family 44 77
JAK Inhibitor Momelotinib Family 33 83
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Amine oxidase [flavin-containing] A Inhibitor 3-benzyl-n-(2-mo... 2 3
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 25 4
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 8 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 5 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... 1 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 1
Platelet-activating factor receptor ligand 5-methyl-2-[4-(2-me... 1 2
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 1 0
Epidermal growth factor receptor ligand pyrido[4,3-d]pyrimidin... 11 0
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Glucosylceramidase and Alpha-galactosidase A inhibitor AC1NNEG... 4 5
G1/S-specific cyclin-D1 and G1/S-specific cyclin-D3 inhibitor ... 6 3
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Serine/threonine-protein kinase mTOR inhibitor SureCN2707225 f... 29 4
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-088SNX f... 1 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Mitogen-activated protein kinase 14 inhibitor SureCN3305171 fa... 1 0
Transient receptor potential cation channel subfamily V member... 2 1
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 1 0
Aurora kinase B and Cyclin-dependent kinase 1 inhibitor 7-cycl... 3 16
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Transient receptor potential cation channel subfamily V member... 4 0
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 6 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Activated CDC42 kinase 1 inhibitor N,N-dimethyl-4-[4-[[(2S)-ox... 3 0
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Smoothened homolog inhibitor N-[4-methyl-3-(5-phenyl-1H-imidaz... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 0
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 1 2
Tyrosine-protein kinase JAK2 inhibitor N,N-dimethyl-4-[[8-(4-m... 2 1
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Thrombopoietin receptor ligand N-[4-[2-fluoro-3-(trifluorometh... 2 14
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Epidermal growth factor receptor ligand AGN-PC-073LJS family 4 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 13
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
P2Y purinoceptor 12 inhibitor (4S)-4-[[6-[4-[2-(methylamino)-2... 51 8
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 12 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 9 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00169075 CHEMBL1204014 Bioactive 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-(4-methylpiperazine-1-carbonyl)phenyl]urea;hydrochloride
CFAMM00169081 CHEMBL1808988 Bioactive 1-[4-[4-(dimethylamino)piperidine-1-carbonyl]phenyl]-3-[4-[4-morpholin-4-yl-6-[(3S)-oxolan-3-yl]oxy-1,3,5-triazin-2-yl]phenyl]urea
CFAMM00169080 CHEMBL1808984 Bioactive 1-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-[4-[4-morpholin-4-yl-6-(oxetan-3-yloxy)-1,3,5-triazin-2-yl]phenyl]urea
CFAMM00169073 CHEMBL1808977 Bioactive N-[2-(dimethylamino)ethyl]-N-methyl-4-[[4-[4-morpholin-4-yl-6-[(3S)-oxolan-3-yl]oxy-1,3,5-triazin-2-yl]phenyl]carbamoylamino]benzamide
CFAMM00169062 CHEMBL1204015 Bioactive N-[2-(dimethylamino)ethyl]-4-[[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoylamino]-N-methylbenzamide;hydrochloride
CFAMM00169072 CHEMBL1808979 Bioactive N-[2-(dimethylamino)ethyl]-4-[[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoylamino]-N-methylbenzamide
CFAMM00169085 CHEMBL592461 Bioactive SureCN32299
CFAMM00169061 CHEMBL592619 Bioactive SureCN32309
CFAMM00169084 CHEMBL1092401 Bioactive SureCN3130219
CFAMM00169065 CHEMBL592615 Bioactive SureCN32264
CFAMM00169082 CHEMBL1808989 Bioactive 4-[[4-[4-morpholin-4-yl-6-[(3S)-oxolan-3-yl]oxy-1,3,5-triazin-2-yl]phenyl]carbamoylamino]-N-(2-piperidin-1-ylethyl)benzamide
CFAMM00169074 DNCL002404 Clinical Trial Drug PF-05212384

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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