CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD704
Family Name Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Inhibitor BYL719 Family
No. of Seeds 3 No. of Other Members 16
Family Centroid CFAMM00169270 Functional Category Clinical Trial Drug
Superfamily Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Inhibitor BYL719 Superfamily
Class Class 1257

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
DNA primase Inhibitor Bay 57-1293 Family 1 2
Metabotropic glutamate receptor 5 Ligand N-[4-(3-pyridylethyny... 2 10
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 8
Protease and Capsid scaffolding protein inhibitor AC1LAC7K family 2 5
Disintegrin and metalloproteinase domain-containing protein 17... 23 5
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 3
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Neuropeptide Y receptor type 5 ligand SureCN6213316 family 3 1
RAC-alpha serine/threonine-protein kinase and Mast/stem cell g... 2 0
Prothrombin and Trypsin-1 inhibitor (2S)-1-[(2R)-2-amino-3,3-d... 1 3
Probable G-protein coupled receptor 142 ligand (2S)-3-phenyl-N... 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00169275 CHEMBL2397196 Bioactive (2S)-1-N-[5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
CFAMM00169270 DNCL002424 Clinical Trial Drug BYL719

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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