CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD72
Family Name Cyclin-dependent kinase 2 Inhibitor Flavopiridol Family
No. of Seeds 4 No. of Other Members 124
Family Centroid CFAMM00132751 Functional Category Clinical Trial Drug with Natural Product
Superfamily Cyclin-dependent kinase 2 Inhibitor Flavopiridol Superfamily
Class Class 872

Cousin Family NamesSeedsMembers
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
DNA Binder Methoxsalen Family 10 1638
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Hidrosmin family 14 61
Ipriflavone family 62 2480
Rotenone family 16 107
Agrimophol family 10 22
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Heat shock protein 90, putative Inhibitor KW-2478 Family 1 14
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
DNA-dependent protein kinase catalytic subunit Inhibitor 7-pro... 5 49
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 14
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Phospholipase A2 Inhibitor 3,9-dihydroxy-2,10-diprenylpterocap... 9 25
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Beta-2 adrenergic receptor Ligand Gnf-pf-1694 Family 4 70
Protein kinase C gamma type and Protein kinase C alpha type In... 2 1
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 4 10
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 5 334
Peroxisome proliferator-activated receptor gamma ligand (9aS)-... 4 44
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
C-C chemokine receptor type 1 and Chemokine (C-C motif) recept... 11 15
C-C chemokine receptor type 1 and Chemokine (C-C motif) recept... 1 16
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
Estrogen receptor beta and Estrogen receptor ligand AGN-PC-074... 5 4
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 inhibi... 1 1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase and Prelamin... 1 0
Lanosterol synthase inhibitor AC1L9UWE family 1 0
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 inhibi... 1 23
Neuropeptide Y receptor type 5 and Thioredoxin glutathione red... 13 6
Multidrug resistance protein 1 inhibitor CHEMBL1 family 2 0
Survival motor neuron protein and Prelamin-A/C inhibitor CHEMB... 2 32
Breast cancer type 1 susceptibility protein and Huntingtin inh... 1 7
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 2 110
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 7
Estrogen receptor ligand AGN-PC-073KIM family 1 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 11
Putative NP ZINC08878071 Family 9 2
Putative NP ZINC00174842 Family 4 0
hydroxyspiro[3H-chromene-2,4'-piperidine]-4-one NP 1'-acetyl-7... 2 1
NP 1,3,8-trihydroxy-6-methyl-2-(morpholinomethyl)anthracene-9,... 2 0
ethylcarbamate NP ZINC09486061 Family 3 0
NP Agn-pc-05g5on Family 11 0
NP 3-(4-chlorophenyl)-4-oxo-4h-chromen-7-yl Diethylcarbamate F... 6 0
1-benzofuran-3-one NP ZINC02445091 Family 23 0
Putative NP ZINC20357755 Family 11 0
9,10-dihydro-8H-pyrano[2,3-f][1,3]benzoxazin-9-ium-2-one NP Ag... 6 0
NP 2-amino-7-[(2,6-dichlorophenyl)methoxy]-3-(4-methoxyphenyl)... 4 0
6-hydroxy-7-(morpholin-4-ylmethyl)-1-benzofuran-3-one NP ZINC2... 7 0
Putative NP ZINC09192007 Family 4 0
Putative NP ZINC12442415 Family 8 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00132870 DCL001074 Clinical Trial Drug P276-00
CFAMM00132751 DCL000116 Clinical Trial Drug Flavopiridol
CFAMM00132843 DNC000536 Investigative Drug Deschloroflavopiridol
CFAMM00132857 DNC002730 Investigative Drug Flavopiridol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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