CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
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CFam Family Information

CFAM Family ID CFFCD722
Family Name Histone deacetylase 6 Inhibitor ACY-1215 Family
No. of Seeds 10 No. of Other Members 230
Family Centroid CFAMM00169639 Functional Category Clinical Trial Drug with Natural Product
Superfamily Histone deacetylase 6 Inhibitor ACY-1215 Superfamily
Class Class 144

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Prostaglandin G/H synthase 2 Inhibitor Niflumic Acid Family 7 119
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Prothrombin Inhibitor Dabigatran Family 7 182
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Glucose-dependent insulinotropic receptor Ligand APD668 Family 3 8
Transient receptor potential cation channel subfamily V member... 16 295
Purine nucleoside phosphorylase Inhibitor BCX-34 Family 2 31
Transient receptor potential cation channel subfamily V member... 15 457
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Aurora kinase B and Aurora kinase A Inhibitor PF-03814735 Family 2 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Histone deacetylase 1 Inhibitor Pyroxamide Family 4 13
Amg 423 family 7 47
Serine/threonine-protein kinase mTOR Inhibitor AZD2014 Family 2 41
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
GDC-0349 family 44 77
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
PHA848125 family 13 138
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Tyrosine-protein kinase BTK Inhibitor CC-292 Family 6 10
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family 11 42
XL-888 family 16 85
PF-4136309 family 16 27
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Arachidonate 5-lipoxygenase Inhibitor Ici 207968 Family 3 7
Class II cytokine receptor Ligand IL-10 Family 7 45
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 6 Inhibi... 2 3
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Tubulin beta chain Inhibitor 2-(3-chloro-phenyl)-1h-[1,8]napht... 3 13
Tubulin beta chain Inhibitor 7-methyl-2-m-tolyl-1h-[1,8]naphth... 7 15
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(6-methylpy... 4 3
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
Adenosine receptor A3 Ligand 2-aminoquinazoline-4-carboxyanili... 4 3
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 2 3
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Tubulin beta chain Inhibitor 2-m-tolyl-1h-[1,8]naphthyridin-4-... 5 2
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Prothrombin inhibitor SureCN7371121 family 13 3
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor SureCN5854779 family 4 9
Prothrombin inhibitor SureCN5856722 family 3 16
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 3
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZYJE fa... 15 5
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 1 7
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 4 14
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Sphingosine 1-phosphate receptor 5 and Sphingosine 1-phosphate... 2 0
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Glycogen synthase kinase-3 beta inhibitor AGN-PC-07ZA4D family 1 0
Mitogen-activated protein kinase 14 inhibitor SureCN3632376 fa... 10 5
Mitogen-activated protein kinase 13 inhibitor N-cyclopropyl-3-... 16 40
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 12 85
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Integrin alpha-V and Integrin beta-5 inhibitor SureCN6563167 f... 2 10
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... 3 7
Transient receptor potential cation channel subfamily V member... 1 4
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Nicotinamide phosphoribosyltransferase inhibitor 4-[(7-chloro-... 6 4
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 2 4
Serine/threonine-protein kinase mTOR and RAC-alpha serine/thre... 3 3
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Adenosine receptor A1 ligand AGN-PC-07PMLW family 6 4
Adenosine receptor A2a ligand SureCN14156209 family 3 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 19
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 2 7
Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... 12 3
Gonadotropin-releasing hormone receptor ligand AGN-PC-075KV1 f... 4 1
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Tyrosine-protein kinase JAK2 inhibitor N-[2-(3-chlorophenyl)-5... 2 11
G1/S-specific cyclin-D1 and G1/S-specific cyclin-D3 inhibitor ... 6 3
Prothrombin and Trypsin-1 inhibitor SureCN12636557 family 9 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 2
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Dihydrofolate reductase inhibitor AC1LAKQL family 3 1
Cellular tumor antigen p53 inhibitor CHEMBL1551403 family 1 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(3,4-di... 3 1
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Glycogen synthase kinase-3 beta inhibitor AGN-PC-0802SH family 1 2
C-C chemokine receptor type 5 ligand SureCN3684128 family 2 2
Coagulation factor X and Kallikrein-1 inhibitor SureCN890858 f... 5 6
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
Coagulation factor X inhibitor AGN-PC-078Y3A family 4 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 13 3
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801305 ... 2 0
Mitogen-activated protein kinase 9 and MAP kinase-activated pr... 1 0
Nicotinamide phosphoribosyltransferase inhibitor 4-[[(7-chloro... 1 1
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Dihydrofolate reductase inhibitor 1-[3-(2,4-diaminoquinazolin-... 2 4
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(1H-pyr... 2 8
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
B1 bradykinin receptor ligand 6-(8-fluoro-4-methyl-1-oxophthal... 3 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Vascular endothelial growth factor receptor 2 ligand urea deri... 3 9
Mitogen-activated protein kinase 14 inhibitor SureCN3305171 fa... 1 0
Transient receptor potential cation channel subfamily V member... 2 1
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 7 1
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 9 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... 5 2
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 1 5
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 10 0
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Heat shock protein HSP 90-beta inhibitor 1-(2-amino-4-methylqu... 1 2
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Transient receptor potential cation channel subfamily V member... 4 0
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
ALK tyrosine kinase receptor and Insulin receptor ligand 2-[[5... 1 0
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
B1 bradykinin receptor ligand methyl 2-fluoro-6-[3-fluoro-4-[[... 22 11
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Poly [ADP-ribose] polymerase 1 inhibitor 8-[[4-fluoro-3-(4-pyr... 5 2
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
Substance-P receptor ligand Netupitant family 5 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Type-1A angiotensin II receptor ligand 2-[[2-butyl-3-[(4-carbo... 2 4
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 2-[3-[... 1 0
Beta-secretase 1 and Beta-secretase 2 inhibitor 5-[(1R)-3-amin... 8 1
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Smoothened homolog inhibitor N-[4-methyl-3-(5-phenyl-1H-imidaz... 1 0
Smoothened homolog inhibitor 3-pyridin-3-yl-N-[1-[[6-[4-[(3-py... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Aurora kinase A inhibitor Bisanilinopyrimidine, 6i family 1 0
Aurora kinase A inhibitor Bisanilinopyrimidine, 6j family 2 1
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 0
ALK tyrosine kinase receptor ligand N-[6-[[4-(2-hydroxypropan-... 2 0
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 4 8
Serine/threonine-protein kinase TBK1 and 3-phosphoinositide-de... 3 3
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 3 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
3-phosphoinositide-dependent protein kinase 1 and Serine/threo... 2 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-(6-pyrrolid... 3 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
Tyrosine-protein kinase receptor TYRO3 and P-selectin ligand 2... 2 3
Tyrosine-protein kinase receptor TYRO3 and Mitogen-activated p... 3 7
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
Protein-cysteine N-palmitoyltransferase porcupine inhibitor 2-... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 2 0
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Non-receptor tyrosine-protein kinase TYK2 ligand SureCN1298914... 3 0
Non-receptor tyrosine-protein kinase TYK2 ligand SureCN3514789... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
C-C chemokine receptor type 5 ligand N-[3-[4-[3-cyclohexyl-5-(... 5 4
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 7 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
Epidermal growth factor receptor ligand N-[3-[2-(4-morpholin-4... 2 2
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Ephrin type-A receptor 3 and Tyrosine-protein kinase Fgr ligan... 1 3
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 7
Macrophage colony-stimulating factor 1 receptor and Mast/stem ... 27 4
Coagulation factor X inhibitor 5-bromo-N-(5-chloropyridin-2-yl... 1 1
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 1
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Prothrombin inhibitor AGN-PC-073GVF family 12 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 1
Integrin beta-3 and Integrin alpha-V inhibitor 2-[(2S)-4-methy... 2 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-00CD7W family 5 5
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[4-oxo-3-(4-p... 2 1
Receptor-type tyrosine-protein kinase FLT3 ligand 4-[6-amino-5... 1 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 13
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 2 1
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Epidermal growth factor receptor ligand (E)-1-[4-(3-bromoanili... 9 0
Cathepsin S and Cathepsin K inhibitor 2-cyano-N-[(2R)-1-phenyl... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 4
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Macrophage colony-stimulating factor 1 receptor ligand N-[3-[(... 5 0
Adenosine receptor A1 and Adenosine receptor A3 ligand CHEMBL4... 2 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Transient receptor potential cation channel subfamily V member... 1 0
Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... 4 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 0
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 5 0
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Transient receptor potential cation channel subfamily V member... 3 2
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 4 0
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
Collagenase 3 inhibitor MMP-13 Inhibitor family 1 1
Egl nine homolog 1 inhibitor 2-[(1,6-diphenylimidazo[4,5-c]pyr... 1 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 16 3
Cannabinoid receptor 2 ligand AGN-PC-07CRHA family 4 8
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 1
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 0
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
C-C chemokine receptor type 5 ligand AC1MHPAK family 5 1
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 1 11
Rho-associated protein kinase 1 inhibitor AGN-PC-07COKD family 1 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R96X family 7 1
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Dihydrofolate reductase inhibitor N-(2,4-diamino-5-methylquina... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(2,6... 1 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 1 0
Histone deacetylase 1 inhibitor AGN-PC-07ZGOS family 1 0
Tyrosine-protein kinase ABL1 inhibitor (3aS,4S,6aR)-4-[5-[3-[[... 1 0
Transcription factor AP-1 and Nuclear factor NF-kappa-B p105 s... 2 4
Glycogen synthase kinase-3 beta inhibitor AGN-PC-09QMXG family 2 5
Diacylglycerol O-acyltransferase 1 inhibitor 2-[4-[4-(4-amino-... 2 3
Cannabinoid receptor 2 ligand SureCN13503317 family 7 7
Glucagon receptor ligand AGN-PC-0DAH9I family 1 0
Amine oxidase [flavin-containing] B and Metabotropic glutamate... 2 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 0
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 inhibi... 1 2
Prolyl endopeptidase inhibitor SureCN8938580 family 1 0
Histone deacetylase 1 inhibitor SureCN4538615 family 2 2
Coagulation factor X and Prothrombin inhibitor SureCN6578740 f... 1 0
Glycogen synthase kinase-3 beta inhibitor SureCN13987027 family 1 0
Potassium voltage-gated channel subfamily KQT member 3 and Pot... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 2
Vascular endothelial growth factor receptor 2 and Insulin rece... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00169761 CHEMBL2442479 Bioactive 4-[4-[2-(2,2-dimethylpropylamino)-2-oxoethyl]anilino]-2-prop-1-en-2-ylpyrimidine-5-carboxamide
CFAMM00169733 CHEMBL471113 Bioactive SureCN2386837
CFAMM00169858 CHEMBL470949 Bioactive AGN-PC-078VDS
CFAMM00169728 CHEMBL2442473 Bioactive 4-[4-[2-(hydroxyamino)-2-oxoethyl]anilino]-2-phenylpyrimidine-5-carboxamide
CFAMM00169762 CHEMBL2442472 Bioactive 4-[4-[2-(2,2-dimethylpropylamino)-2-oxoethyl]anilino]-2-phenylpyrimidine-5-carboxamide
CFAMM00169639 DNCL002535 Clinical Trial Drug ACY-1215
CFAMM00169752 DNC007459 Investigative Drug 2-(2-(phenylamino)pyrimidin-4-ylamino)benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27264 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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