CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD724
Family Name Ibrutinib family
No. of Seeds 2 No. of Other Members 27
Family Centroid CFAMM00169965 Functional Category Clinical Trial Drug
Superfamily Ibrutinib Superfamily
Class Class 851

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Corticotropin-releasing factor receptor 1 Ligand GSK561679 Family 5 6
Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Family 24 11
Adenosine receptor A2a Ligand BIIB014 Family 26 92
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
PF-02545920 family 16 140
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 4 32
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 37
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Epidermal growth factor receptor and Tyrosine-protein kinase A... 4 3
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CC4... 20 7
Epidermal growth factor receptor and Cyclin-dependent kinase 1... 3 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11
Proto-oncogene tyrosine-protein kinase Src and Phosphatidylino... 4 20
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 3 6
Adenosine receptor A3 and Adenosine receptor A2a ligand 4-(5-b... 2 5
Tyrosine-protein kinase ABL1 and Tyrosine-protein kinase HCK i... 2 2
Tyrosine-protein kinase HCK and Proto-oncogene tyrosine-protei... 5 9
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 12 8
Translocator protein inhibitor AGN-PC-080ILF family 9 3
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 5
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Proto-oncogene tyrosine-protein kinase Src and Epidermal growt... 9 9
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 1
Neuropeptide Y receptor type 1 ligand CP-671906 family 10 0
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Corticotropin-releasing factor receptor 1 ligand CHEMBL1819076... 2 0
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Corticotropin-releasing factor receptor 1 ligand CHEMBL1830528... 1 0
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
Hepatocyte growth factor receptor ligand 5-[[6-(3-hydroxypheny... 2 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 17
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 4 4
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YLX fa... 3 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 9
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Tyrosine-protein kinase SYK inhibitor 4-[[3-[8-[(5,6-dimethoxy... 2 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
Estrogen receptor and Estrogen receptor beta ligand 4-[3-[4-(2... 1 0
Glucose-dependent insulinotropic receptor ligand 2-[1-(5-ethyl... 2 1
Metabotropic glutamate receptor 2 ligand 8-chloro-3-(cycloprop... 6 2
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 4 9
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dih... 1 5
Substance-P receptor ligand (2S,3S)-N-[[2-methoxy-5-(tetrazol-... 2 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 3
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074EV8... 1 0
Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 4
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CCL... 3 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Aurora kinase A and Glycogen synthase kinase-3 beta inhibitor ... 1 2
Glucokinase inhibitor AGN-PC-03ZE5E family 1 0
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor AGN-PC... 2 0
Acyl-CoA desaturase 1 inhibitor Pyridazine, 3-[4-(2-ethylpheno... 4 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D inhibitor Sure... 2 6
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Tyrosine-protein kinase Lck and Angiopoietin-1 receptor ligand... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00169961 CHEMBL2057912 Bioactive 1-cyclopentyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-amine
CFAMM00169965 DNCL002550 Clinical Trial Drug Ibrutinib

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48716 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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