CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD737
Family Name Acolbifene family
No. of Seeds 10 No. of Other Members 115
Family Centroid CFAMM00170471 Functional Category Clinical Trial Drug with Natural Product
Superfamily Acolbifene Superfamily
Class Class 1273

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
Beta-2 adrenergic receptor Ligand Bambuterol Family 4 9
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Neuronal acetylcholine receptor subunit alpha-2 Ligand Metocur... 18 169
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Substance-P receptor Ligand Ezlopitant Family 10 207
5-hydroxytryptamine receptor 1A Ligand MN-305 Family 12 26
TS-071 family 8 36
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Oestrogen receptor and Tyrosine-protein phosphatase non-recept... 92 21
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Platelet-activating factor receptor Ligand L-652731 Family 5 116
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
DNA-dependent protein kinase catalytic subunit Inhibitor 4-mor... 7 54
DNA-dependent protein kinase catalytic subunit Inhibitor 7-pro... 5 49
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor Ligand 4-isopropyl-2-(phenoxymethyl)morp... 4 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Histamine H3 receptor Ligand 1-(3-(2-(3-methoxyphenoxy)ethoxy)... 3 9
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Cytochrome P450 2D6 Inhibitor 4-methylaminomethyl-7-methoxycou... 3 80
Tyrosine-protein phosphatase non-receptor type 1 and Neuramini... 10 2
Renin Inhibitor Ro-65-7219 Family 10 8
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Androgen receptor Ligand Palodesangren E Family 12 43
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 2 2
Estrogen receptor and Estrogen receptor beta ligand CHEMBL1087... 2 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 10 6
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
Alpha-1A adrenergic receptor and 5-hydroxytryptamine receptor ... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 8
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 7 4
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 5 334
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Muscarinic acetylcholine receptor M3 and Beta-2 adrenergic rec... 2 1
Estrogen receptor and Estrogen receptor beta ligand (2R,3R,4S)... 3 0
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 191
5-hydroxytryptamine receptor 7 and Alpha-2C adrenergic recepto... 3 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Estrogen receptor and Estrogen receptor beta ligand SureCN3115... 9 0
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00E... 7 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 7
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 0
Substance-P receptor ligand (5S,10S)-5-(4-fluorophenyl)-10-(2-... 3 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 11
Histamine H3 receptor and Sodium-dependent serotonin transport... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand Desac... 2 3
Vesicular acetylcholine transporter inhibitor (2R,3R)-5-(3-flu... 2 0
Estrogen receptor and Estrogen receptor beta ligand SureCN8476... 2 1
Estrogen receptor and Estrogen receptor beta ligand (2R,3S)-5-... 1 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 3
C-C chemokine receptor type 4 ligand AGN-PC-07AKPI family 1 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 7
NP 1-(7-hydroxyspiro[chroman-2,4'-piperidin]-1'-yl)ethanone Fa... 2 0
Putative NP ZINC01322649 Family 2 0
NP Ethyl 4-((6,8-dimethyl-2-oxo-2h-chromen-4-yl)methyl)piperaz... 3 0
methylchromen-2-one NP Agn-pc-05gg75 Family 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00170528 CHEMBL291808 Bioactive (2S)-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-[2-(1-PIPERIDYL)ETHOXY]PHENYL]-2H-CHROMEN-7-OL
CFAMM00170556 CHEMBL67783 Bioactive SureCN7943653
CFAMM00170518 CHEMBL67837 Bioactive AC1O0TTD
CFAMM00170471 DNCL002602 Clinical Trial Drug Acolbifene
CFAMM00170521 DNC010661 Investigative Drug JNJ-19398990
CFAMM00170464 DNC010659 Investigative Drug JNJ-26529126
CFAMM00170463 DNC010658 Investigative Drug JNJ-17148066
CFAMM00170551 DNC000602 Investigative Drug EM-800
CFAMM00170522 DNC010660 Investigative Drug JNJ-26529152
CFAMM00170487 DNC004124 Investigative Drug (R)-2-(Benzylamino-methyl)-chroman-7-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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