CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD741
Family Name E7820 family
No. of Seeds 9 No. of Other Members 56
Family Centroid CFAMM00170658 Functional Category Clinical Trial Drug
Superfamily 5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Superfamily
Class Class 8

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Thromboxane A2 receptor Ligand Ramatroban Family 13 49
5-hydroxytryptamine receptor 6 Ligand SB-742457 Family 9 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Indisu... 2 14
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Prostaglandin G/H synthase 2 Inhibitor 2-(4-(methylsulfonyl)ph... 7 33
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Motilin receptor and Cytochrome P450 2D6 ligand 7-[[6-(4-chlor... 2 1
Protein kinase C theta type and Protein kinase C delta type in... 7 17
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Protein kinase C theta type and Protein kinase C delta type in... 16 8
5-hydroxytryptamine receptor 6 ligand N-methyl-1-[(1R)-6-(1H-p... 3 0
5-hydroxytryptamine receptor 6 ligand CHEMBL1950756 family 8 8
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
Cathepsin L1 inhibitor Bio2_000267 family 9 1
Cannabinoid receptor 2 ligand AGN-PC-09M5PW family 12 2
Cannabinoid receptor 2 ligand 1,1,1-trifluoro-N-[(2S)-6-(1-pyr... 2 1
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 8
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 5 10
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Glucocorticoid receptor ligand 2,4,6-trimethyl-N-[(2S)-1-[[6-m... 16 1
Progesterone receptor and Mineralocorticoid receptor ligand AG... 6 1
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 5 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6
Hepatocyte growth factor receptor ligand AGN-PC-08XYH3 family 1 0
5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3
5-hydroxytryptamine receptor 6 and Muscarinic acetylcholine re... 7 3
5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... 8 4
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 12 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 7 1
5-hydroxytryptamine receptor 6 ligand 9-(2-bromophenyl)sulfony... 2 0
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 5 2
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
5-hydroxytryptamine receptor 7 ligand 6-[(2R)-2-[2-(4-methylpi... 1 0
5-hydroxytryptamine receptor 6 ligand 3,4-dichloro-N-[3-[[(2R)... 5 0
Protein kinase C theta type and Protein kinase C delta type in... 4 5
CGMP-dependent protein kinase inhibitor 2-[[4-[5-(4-fluorophen... 1 0
Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 3 3
5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 6 0
Protein kinase C theta type and Tyrosine-protein kinase Fyn in... 4 0
Prostaglandin G/H synthase 2 inhibitor AGN-PC-03NCPN family 4 0
Prostaglandin G/H synthase 2 inhibitor SureCN6345015 family 6 1
Prostaglandin G/H synthase 2 inhibitor AGN-PC-03NCPD family 6 2
5-hydroxytryptamine receptor 6 ligand 2-[[(1Z)-1-[5-(benzenesu... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 6 ligand 4-bromo-N-[3-[[(2S)-1-me... 4 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00170634 CHEMBL1079903 Bioactive 4-[(E)-2-[5-cyano-4-[(4-methyl-1H-indol-5-yl)amino]pyridin-3-yl]ethenyl]-N,N-diethylbenzenesulfonamide
CFAMM00170614 CHEMBL1081359 Bioactive SureCN2936566
CFAMM00170613 CHEMBL1080995 Bioactive SureCN2934911
CFAMM00170645 CHEMBL1079566 Bioactive SureCN2933675
CFAMM00170618 CHEMBL1080994 Bioactive SureCN2934634
CFAMM00170631 CHEMBL1080801 Bioactive SureCN2935609
CFAMM00170604 CHEMBL1080103 Bioactive SureCN2936068
CFAMM00170616 CHEMBL1081358 Bioactive SureCN2933471
CFAMM00170658 DNCL002615 Clinical Trial Drug E7820

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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