CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD75
Family Name Telomerase protein component 1 Inhibitor GRN163L Family
No. of Seeds 5 No. of Other Members 29
Family Centroid CFAMM00132917 Functional Category Clinical Trial Drug
Superfamily Telomerase protein component 1 Inhibitor GRN163L Superfamily
Class Class 874

Cousin Family NamesSeedsMembers
Cytochrome P450 3A4 Inhibitor Clotrimazole Family 16 145
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Benzodiazepine receptor Ligand Midazolam Family 5 160
14-alpha sterol demethylase Inhibitor Butoconazole Family 2 53
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
HCV NS4B protein Inhibitor Clemizole Family 2 43
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
Nitric oxide synthase, inducible Inhibitor 4-(1h-imidazol-1-yl... 1 7
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Thromboxane-A synthase Inhibitor CGS-13080 Family 3 19
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 6-im... 2 30
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 2
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-aminobenzyl... 3 6
Cytochrome P450 2D6 Inhibitor GBR-12289 Family 1 0
Aromatase Inhibitor 4-((1h-imidazol-1-yl)methyl)-2h-chromen-2-... 3 69
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor Rac-4'-(1-i... 5 9
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 6 6
Cytochrome P450 11B1, mitochondrial Inhibitor (3-((1h-imidazol... 2 5
Cytochrome P450 11B1, mitochondrial Inhibitor 3-(1-benzyl-1h-i... 3 5
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 2 1
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 1 1
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 1 0
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor 1-(4-nitrob... 3 5
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 2 8
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Aromatase Inhibitor 2-(1h-imidazol-1-yl)-1-(4-nitrophenyl)etha... 2 29
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor 1-(3,4-dich... 1 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 7
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 1 6
Aromatase inhibitor AGN-PC-075MV1 family 1 3
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
Delta-type opioid receptor and Kappa-type opioid receptor liga... 10 4
Progesterone receptor and Cytochrome P450 2C19 ligand AGN-PC-0... 8 3
Thromboxane-A synthase inhibitor SureCN11474904 family 1 6
Heme oxygenase 1 and Heme oxygenase 2 inhibitor 1-imidazol-1-y... 2 2
Glutaminyl-peptide cyclotransferase inhibitor SureCN10144417 f... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00132917 DCL000122 Clinical Trial Drug GRN163L
CFAMM00132945 DNC010490 Investigative Drug BENZYLIMIDAZOLE
CFAMM00132944 DNC010493 Investigative Drug (4-((1H-imidazol-1-yl)methyl)phenyl)methanol
CFAMM00132934 DNC013091 Investigative Drug 1-(4-methyl-benzyl)-1H-imidazole
CFAMM00132951 DNC001084 Investigative Drug Ozagrel hydrochloride

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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