CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD750
Family Name SCH-900776 family
No. of Seeds 8 No. of Other Members 14
Family Centroid CFAMM00170895 Functional Category Clinical Trial Drug
Superfamily SCH-900776 Superfamily
Class Class 1279

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Type-1 angiotensin II receptor Ligand Forasartan Family 3 253
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
PF-4217903 family 14 65
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 5 1
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Adenosine receptor A3 and Adenosine receptor A2a ligand SureCN... 8 7
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 1
Serine/threonine-protein kinase Chk1 and Cyclin-A2 inhibitor S... 1 1
Serine/threonine-protein kinase Chk1 and Cyclin-A2 inhibitor A... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 5
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 0
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 0
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 1
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 2 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Tyrosine-protein kinase JAK2 inhibitor [4-[[5-(1-ethylpyrazol-... 2 3
ALK tyrosine kinase receptor ligand 3-[1-[(3-fluorophenyl)meth... 2 0
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
High affinity nerve growth factor receptor ligand SureCN490352... 3 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00170892 CHEMBL1643207 Bioactive SureCN11930793
CFAMM00170898 CHEMBL1643234 Bioactive AGN-PC-09QLWZ
CFAMM00170897 CHEMBL1643235 Bioactive AGN-PC-09QMQM
CFAMM00170910 CHEMBL2386889 Bioactive 6-bromo-3-(1-methylpyrazol-4-yl)-5-[(3R)-piperidin-3-yl]pyrazolo[1,5-a]pyrimidin-7-amine
CFAMM00170896 CHEMBL1643236 Bioactive 5-[[(1S,3R)-3-aminocyclohexyl]methyl]-6-bromo-3-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-7-amine
CFAMM00170889 CHEMBL1643209 Bioactive AGN-PC-07RFJJ
CFAMM00170902 CHEMBL1643230 Bioactive SureCN11930859
CFAMM00170895 DNCL002660 Clinical Trial Drug SCH-900776

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24631 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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