CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD76
Family Name Serine/threonine-protein kinase PLK1 Inhibitor GSK461364 Family
No. of Seeds 40 No. of Other Members 84
Family Centroid CFAMM00132983 Functional Category Clinical Trial Drug
Superfamily Serine/threonine-protein kinase PLK1 Inhibitor GSK461364 Superfamily
Class Class 875

Cousin Family NamesSeedsMembers
Multiple kinase Inhibitor MGCD265 Family 19 71
Serine/threonine-protein kinase PLK1 and Cytochrome P450 2C9 i... 7 0
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 1
Elongation factor 1-alpha 1 and Elongation factor 1-alpha 2 in... 2 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
E-selectin and Intercellular adhesion molecule 1 inhibitor 4-(... 2 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Serine/threonine-protein kinase PLK1 and Death-associated prot... 2 1
Serine/threonine-protein kinase PLK1 inhibitor SureCN2523858 f... 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00133052 CHEMBL519120 Bioactive AGN-PC-050ULD
CFAMM00132979 CHEMBL1615278 Bioactive SureCN2977519
CFAMM00133026 CHEMBL1964263 Bioactive SureCN2982249
CFAMM00132993 CHEMBL1208964 Bioactive 3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-[5-[2-[(1-methylpiperidin-4-yl)amino]pyridin-4-yl]benzimidazol-1-yl]thiophene-2-carboxamide
CFAMM00133045 CHEMBL1209674 Bioactive SureCN4404322
CFAMM00133072 CHEMBL481510 Bioactive GW853606X
CFAMM00133051 CHEMBL1208894 Bioactive SureCN4412158
CFAMM00133078 CHEMBL1208835 Bioactive SureCN3150935
CFAMM00132992 CHEMBL1208966 Bioactive 3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-[5-[2-[(1-methylpiperidin-4-yl)amino]pyrimidin-4-yl]benzimidazol-1-yl]thiophene-2-carboxamide
CFAMM00132998 CHEMBL1208961 Bioactive SureCN3569179
CFAMM00133044 CHEMBL1209675 Bioactive 3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-(6-pyridin-4-ylbenzimidazol-1-yl)thiophene-2-carboxamide
CFAMM00133011 CHEMBL1209759 Bioactive SureCN3146085
CFAMM00132964 CHEMBL522709 Bioactive GSK317315A
CFAMM00133004 CHEMBL1689158 Bioactive AGN-PC-00S6HC
CFAMM00133030 CHEMBL1209606 Bioactive 5-(6-pyridin-4-ylbenzimidazol-1-yl)-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide
CFAMM00132997 CHEMBL1208960 Bioactive 5-[5-(2-morpholin-4-ylpyridin-4-yl)benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide
CFAMM00133010 CHEMBL1209758 Bioactive SureCN4407569
CFAMM00132963 CHEMBL474843 Bioactive SureCN6041406
CFAMM00133049 CHEMBL1208893 Bioactive SureCN4551471
CFAMM00132959 CHEMBL1689163 Bioactive AGN-PC-08XU4X
CFAMM00132990 CHEMBL514968 Bioactive AGN-PC-050ULH
CFAMM00133016 CHEMBL1209841 Bioactive 5-[5-(1-methylpyrazol-4-yl)benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide
CFAMM00133062 CHEMBL1614933 Bioactive AGN-PC-08XU4Y
CFAMM00133076 CHEMBL1208833 Bioactive 5-[5-(2-chloropyridin-4-yl)benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide
CFAMM00132969 CHEMBL514499 Bioactive GW843682X
CFAMM00133029 CHEMBL1209605 Bioactive SureCN4404515
CFAMM00132996 CHEMBL1208963 Bioactive SureCN3576000
CFAMM00133048 CHEMBL1208892 Bioactive 5-[5-(2-aminopyrimidin-4-yl)benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide
CFAMM00132968 CHEMBL1794068 Bioactive GSK326090A
CFAMM00133008 CHEMBL1209757 Bioactive SureCN4402968
CFAMM00133021 CHEMBL1208958 Bioactive 3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-[5-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]benzimidazol-1-yl]thiophene-2-carboxamide
CFAMM00133047 CHEMBL1209676 Bioactive SureCN4410014
CFAMM00132980 CHEMBL1794070 Bioactive GSK579289A
CFAMM00132994 CHEMBL1208965 Bioactive SureCN3142037
CFAMM00133007 CHEMBL1209756 Bioactive SureCN4551448
CFAMM00133020 CHEMBL1208959 Bioactive SureCN3150468
CFAMM00133033 CHEMBL1209603 Bioactive 5-(5-phenylbenzimidazol-1-yl)-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide
CFAMM00133046 CHEMBL1209677 Bioactive 5-(6-pyridin-3-ylbenzimidazol-1-yl)-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide
CFAMM00133013 CHEMBL1209844 Bioactive SureCN4563270
CFAMM00132983 DCL000123 Clinical Trial Drug GSK461364

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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