CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD763
Family Name Elagolix family
No. of Seeds 43 No. of Other Members 98
Family Centroid CFAMM00171179 Functional Category Clinical Trial Drug
Superfamily Elagolix Superfamily
Class Class 1003

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Zucapsacin family 7 177
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histamine H3 receptor Ligand A-349821 Family 49 228
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Neutrophil elastase inhibitor SureCN7276506 family 2 7
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Neutrophil elastase inhibitor benzyl 2-[2,4,8-trioxo-7-[2-oxo-... 2 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 4
Histamine H1 receptor and Histamine H3 receptor ligand 4-[(4-m... 3 6
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Histamine H3 receptor ligand 4-[[2-[2-[(2R)-2-methylpyrrolidin... 1 1
Gonadotropin-releasing hormone receptor ligand 5-(2-chloro-3-m... 5 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Gonadotropin-releasing hormone receptor ligand 3-[(2R)-2-amino... 2 0
Gonadotropin-releasing hormone receptor ligand SureCN6662468 f... 2 0
Gonadotropin-releasing hormone receptor ligand 4-[(2R)-2-amino... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name
CFAMM00171050 CHEMBL180076 Bioactive 1-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyl-3-[(2R)-2-(methylamino)-2-phenylethyl]pyrimidine-2,4-dione
CFAMM00171117 CHEMBL509075 Bioactive SureCN1378026
CFAMM00171178 CHEMBL116074 Bioactive 1-[(2,6-difluorophenyl)methyl]-3-[(2S)-2-(dimethylamino)-3-phenylpropyl]-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4-dione
CFAMM00171191 CHEMBL502341 Bioactive 4-[[(1R)-2-[3-[(2-chloro-6-fluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)-4-methyl-2,6-dioxopyrimidin-1-yl]-1-phenylethyl]amino]butanoic acid
CFAMM00171096 CHEMBL468551 Bioactive SureCN1643197
CFAMM00171056 CHEMBL401632 Bioactive 3-[(2S)-2-(cyclopentylamino)butyl]-5-(2-fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methylpyrimidine-2,4-dione
CFAMM00171062 CHEMBL179269 Bioactive 1-[(2,6-difluorophenyl)methyl]-5-(3-methoxyphenyl)-6-methyl-3-[(2R)-2-(methylamino)-2-phenylethyl]pyrimidine-2,4-dione
CFAMM00171157 CHEMBL506877 Bioactive 4-[[(1R)-2-[3-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)-4-methyl-2,6-dioxopyrimidin-1-yl]-1-phenylethyl]amino]butanoic acid
CFAMM00171095 CHEMBL510538 Bioactive 5-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-1-yl]-1-phenylethyl]amino]pentanoic acid
CFAMM00171055 CHEMBL453441 Bioactive SureCN1382396
CFAMM00171149 CHEMBL117670 Bioactive SureCN128054
CFAMM00171088 CHEMBL119774 Bioactive 3-[(2R)-2-cyclohexyl-2-(dimethylamino)ethyl]-1-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4-dione
CFAMM00171101 CHEMBL449373 Bioactive 4-[3-[1-[(2R)-2-amino-2-phenylethyl]-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-5-yl]-2-fluorophenoxy]butanoic acid
CFAMM00171128 CHEMBL283170 Bioactive 1-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyl-3-[(2R)-1-[(2-methylphenyl)methylamino]propan-2-yl]pyrimidine-2,4-dione
CFAMM00171189 CHEMBL179429 Bioactive 1-[(2,6-difluorophenyl)methyl]-3-[(2R)-2-(dimethylamino)-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4-dione
CFAMM00171094 CHEMBL434936 Bioactive 3-[(2R)-2-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]pyrimidine-2,4-dione
CFAMM00171108 CHEMBL191817 Bioactive 3-[(2R)-2-amino-2-phenylethyl]-1-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)pyrimidine-2,4-dione
CFAMM00171121 CHEMBL454774 Bioactive SureCN1382232
CFAMM00171182 CHEMBL359894 Bioactive 3-[(2R)-2-amino-2-phenylethyl]-1-[(2,6-difluorophenyl)methyl]-5-(3-methoxyphenyl)-6-methylpyrimidine-2,4-dione
CFAMM00171100 CHEMBL449468 Bioactive 5-[3-[1-[(2R)-2-amino-2-phenylethyl]-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-5-yl]phenoxy]pentanoic acid
CFAMM00171162 CHEMBL407719 Bioactive 3-[(2R)-2-(cyclopentylamino)-3-hydroxypropyl]-1-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4-dione
CFAMM00171175 CHEMBL116071 Bioactive 1-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyl-3-[(2R)-4-methyl-2-(methylamino)pentyl]pyrimidine-2,4-dione
CFAMM00171141 CHEMBL510285 Bioactive methyl 4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-1-yl]-1-phenylethyl]amino]butanoate
CFAMM00171053 CHEMBL326504 Bioactive SureCN2704076
CFAMM00171181 CHEMBL370711 Bioactive 3-[(2R)-2-amino-2-phenylethyl]-5-(2-fluoro-3-propan-2-yloxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]pyrimidine-2,4-dione
CFAMM00171099 CHEMBL324912 Bioactive 1-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyl-3-[(2S)-2-(methylamino)-3-phenylpropyl]pyrimidine-2,4-dione
CFAMM00171187 CHEMBL448253 Bioactive 4-[3-[1-[(2R)-2-amino-2-phenylethyl]-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-5-yl]phenoxy]butanoic acid
CFAMM00171154 CHEMBL259907 Bioactive 3-[(2S)-2-(cyclopentylamino)propyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-5-(3-methoxyphenyl)-6-methylpyrimidine-2,4-dione
CFAMM00171180 CHEMBL423291 Bioactive 1-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)-3-[(2R)-1-[(2-methoxyphenyl)methylamino]propan-2-yl]-6-methylpyrimidine-2,4-dione
CFAMM00171119 CHEMBL192096 Bioactive 3-[(2R)-2-amino-2-phenylethyl]-5-[2-fluoro-3-(2,2,2-trifluoroethoxy)phenyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]pyrimidine-2,4-dione
CFAMM00171146 CHEMBL279885 Bioactive 1-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyl-3-[(2S)-2-(pentan-3-ylamino)propyl]pyrimidine-2,4-dione
CFAMM00171072 CHEMBL506338 Bioactive 2-[2-[2-fluoro-3-[1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-3-[(2R)-2-(methylamino)-2-phenylethyl]-2,4-dioxopyrimidin-5-yl]phenoxy]ethoxy]acetic acid
CFAMM00171098 CHEMBL22653 Bioactive 3-[(2S)-2-(cyclopentylamino)propyl]-1-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4-dione
CFAMM00171186 CHEMBL119808 Bioactive 3-[(2R)-2-amino-2-cyclopentylethyl]-1-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4-dione
CFAMM00171085 CHEMBL553990 Bioactive 3-[2-(cyclobutylamino)propyl]-1-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4-dione;hydrochloride
CFAMM00171078 CHEMBL503705 Bioactive SureCN14448687
CFAMM00171153 CHEMBL259906 Bioactive 3-[(2S)-2-(cyclopentylamino)propyl]-5-(2-fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methylpyrimidine-2,4-dione
CFAMM00171104 CHEMBL505033 Bioactive 6-[3-[1-[(2R)-2-amino-2-phenylethyl]-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-5-yl]-2-fluorophenoxy]hexanoic acid
CFAMM00171192 CHEMBL451916 Bioactive SureCN1380100
CFAMM00171145 CHEMBL190929 Bioactive 3-[(2R)-2-amino-2-phenylethyl]-5-(3-ethoxy-2-fluorophenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]pyrimidine-2,4-dione
CFAMM00171124 CHEMBL179600 Bioactive 3-[(2S)-2-(cyclobutylamino)propyl]-1-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4-dione
CFAMM00171179 DNCL002721 Clinical Trial Drug Elagolix
CFAMM00171087 DNC004857 Investigative Drug NBI-42902

Statistics of CFAM Database
 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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