CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD771
Family Name Intedanib family
No. of Seeds 7 No. of Other Members 54
Family Centroid CFAMM00171276 Functional Category Clinical Trial Drug with Natural Product
Superfamily Histone deacetylase 1 and Tyrosine-protein kinase JAK2 Binder Superfamily
Class Class 271

Cousin Family NamesSeedsMembers
Retinoic acid receptor alpha Ligand Tamibarotene Family 5 95
Prostaglandin G/H synthase 2 Inhibitor Mefenamic Acid Family 7 137
Cholecystokinin receptor type A Ligand Gi 181771 Family 3 18
Amonafide family 3 35
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Aurora kinase B Inhibitor Hesperadin Family 1 1
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
Cathepsin S inhibitor methyl 2-amino-4-[[(2S)-3-cyclohexyl-1-[... 2 3
Prolyl endopeptidase inhibitor benzyl (2R)-2-[(2S)-2-formylpyr... 2 1
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 3 3
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 5 2
C-C chemokine receptor type 3 ligand SureCN6704607 family 3 22
Retinal dehydrogenase 1 and Menin inhibitor CHEMBL1507858 family 1 6
Cellular tumor antigen p53 inhibitor CHEMBL1554992 family 1 0
Prostaglandin E2 receptor EP4 subtype ligand SureCN3567929 family 10 3
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Neuropeptide Y receptor type 5 ligand SureCN3382773 family 1 13
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[1-[2-[4-[(2... 2 8
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Melanin-concentrating hormone receptor 1 ligand methyl 4-[(1S,... 1 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Beta-secretase 1 inhibitor CHEMBL400438 family 5 16
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 7 12
Pol polyprotein inhibitor methyl 3-[(4R,5R,6R)-4-benzyl-5-hydr... 1 0
Vasopressin V2 receptor ligand SureCN4206215 family 1 2
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[[1... 2 5
Protein farnesyltransferase subunit beta and Protein farnesylt... 4 13
Acyl-CoA:cholesterol acyltransferase inhibitor methyl 3-[1-[[[... 1 2
Serine/threonine-protein kinase Chk1 inhibitor 6-oxo-9-(2-oxo-... 1 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 1
Multidrug resistance protein 1 inhibitor [(2R,3S,4R)-4-[[(2S)-... 1 5
NP Methyl 3-acetyl-4-oxo-1,4-dihydroquinoline-8-carboxylate Fa... 2 0
Putative NP ZINC04043929 Family 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00171296 CHEMBL498266 Bioactive SureCN2566882
CFAMM00171295 CHEMBL498265 Bioactive SureCN2571796
CFAMM00171329 CHEMBL498088 Bioactive SureCN2573068
CFAMM00171291 CHEMBL525203 Bioactive SureCN479550
CFAMM00171267 CHEMBL525909 Bioactive SureCN436186
CFAMM00171276 DNCL002785 Clinical Trial Drug Intedanib
CFAMM00171325 DNCL003416 Clinical Trial Drug Nintedanib

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27514 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543