CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD781
Family Name Indeglitazar family
No. of Seeds 3 No. of Other Members 39
Family Centroid CFAMM00171471 Functional Category Clinical Trial Drug with Natural Product
Superfamily 5-hydroxytryptamine receptor 1A Ligand Treximet Superfamily
Class Class 82

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Family 48 78
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
DNA Binder Elliptinium Acetate Family 11 116
Serine/threonine-protein kinase PLK1 Inhibitor HMN-214 Family 3 58
Arachidonate 5-lipoxygenase Inhibitor MK-591 Family 9 161
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor GSK2... 15 18
Prostaglandin E2 receptor EP2 subtype Ligand CP-533536 Family 2 9
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Apricoxib family 8 77
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 1 8
AP endonuclease APE1 Inhibitor 5-fluoro-1h-indole-2-carboxylic... 2 61
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 0
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
Platelet-derived growth factor receptor alpha and Platelet-der... 2 13
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Serine/threonine-protein kinase Chk1 and Wee1-like protein kin... 2 101
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Cyclin-dependent kinase 2 and G1/S-specific cyclin-E1 Inhibito... 5 1
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Prostaglandin G/H synthase 2 Inhibitor 5-methoxy-2-(4-(methyls... 3 12
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 1 18
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
5-hydroxytryptamine receptor 6 ligand N-[3-[[(2R)-1-methylpyrr... 6 0
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Cannabinoid receptor 2 ligand AGN-PC-09M5M9 family 1 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 5
5-hydroxytryptamine receptor 6 ligand SureCN5502542 family 4 2
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 15
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Gonadotropin-releasing hormone receptor ligand AGN-PC-075RJQ f... 3 0
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 20 37
Progesterone receptor and Androgen receptor ligand AGN-PC-04QD... 1 0
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 2 0
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 2 11
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
Collagenase 3 and A disintegrin and metalloproteinase with thr... 5 6
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Macrophage metalloelastase inhibitor (2S)-3-methyl-2-[[8-[3-(t... 2 6
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 3 6
Integrase inhibitor (Z)-4-[1-[(4-fluorophenyl)methyl]-5-methox... 1 0
5-hydroxytryptamine receptor 6 ligand SureCN5253197 family 4 2
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Pancreatic alpha-amylase and Gastrin/cholecystokinin type B re... 7 1
5-hydroxytryptamine receptor 6 ligand 1-(2-bromo-4-methoxyphen... 2 1
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 1
Acetylcholinesterase and Cholinesterase inhibitor N-[5-[(6-chl... 4 2
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 1 1
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-(2-nitropheno... 1 6
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5532501 fa... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 4 1
Neutrophil collagenase and Stromelysin-1 inhibitor (3R)-N-hydr... 2 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 2
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 6 ligand 1-[9-(2,5-dimethoxypheny... 2 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-075BWR family 1 1
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 4 1
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 3 3
Oxytocin receptor and Vasopressin V1a receptor ligand 4-methox... 9 8
Prostaglandin E2 receptor EP3 subtype ligand (E)-3-(1-methyl-4... 14 12
Protein kinase C theta type and Protein kinase C delta type in... 10 7
5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 5
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 2
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 1 6
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 14 2
Sodium-dependent serotonin transporter inhibitor SureCN5477150... 4 1
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 2 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 2 10
Carbonic anhydrase 2 inhibitor (2-sulfamoyl-1H-indol-6-yl) ace... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 1
Acetylcholinesterase and Cholinesterase inhibitor P10358 family 2 0
Glycogen synthase kinase-3 beta and G2/mitotic-specific cyclin... 4 13
Phospholipase A2, membrane associated inhibitor 2-(1-benzyl-2-... 2 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 1 0
Platelet-derived growth factor receptor beta and Vascular endo... 1 3
Sugar Acids and Derivatives Metabolite 6-Hydroxy-5-methoxyindo... 3 1
Indoles Metabolite Mukeic acid Family 1 1
Putative NP ZINC40309500 Family 4 0
1-[1-(furan-2-ylmethyl)-5-hydroxy-2-methylindol-3-yl]ethanone ... 1 0
NP N1-(5-bromo-1-ethyl-2-oxoindolin-3-yl)-N2-(2-(5-methoxy-1H-... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00171471 DNCL002863 Clinical Trial Drug Indeglitazar
CFAMM00171456 DNC005050 Investigative Drug 2-(6-Methoxy-indole-1-sulfonyl)-benzoic acid
CFAMM00171495 DNC003343 Investigative Drug 3-(5-methoxy-1H-indol-3-yl)propanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26816 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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