CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD788
Family Name Grt 6005/06 family
No. of Seeds 4 No. of Other Members 22
Family Centroid CFAMM00171615 Functional Category Clinical Trial Drug with Natural Product
Superfamily Grt 6005/06 Superfamily
Class Class 1304

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Histamine H1 receptor Ligand Doxylamine Family 2 91
Food vacuoles Inhibitor Mefloquine Family 2 25
5-hydroxytryptamine receptor Ligand Metergolin Family 2 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
DNA-dependent protein kinase catalytic subunit Inhibitor 2-(1h... 2 0
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
D(1B) dopamine receptor and D(2) dopamine receptor Ligand Flut... 1 6
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 4 53
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Glucocorticoid receptor ligand SureCN5650626 family 17 25
Glucocorticoid receptor ligand AGN-PC-0A9RHA family 1 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Muscarinic acetylcholine receptor M3 ligand 3-fluoro-2-(3-pipe... 3 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Melanin-concentrating hormone receptor 2 ligand (2R)-1'-(9H-ca... 2 10
CGMP-dependent protein kinase inhibitor AGN-PC-075XJ0 family 9 1
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Transporter and Sodium-dependent serotonin transporter inhibit... 2 1
Neuropeptide Y receptor type 5 ligand 2-phenyl-4-(6-propylsulf... 12 5
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
5-hydroxytryptamine receptor 2A ligand (3R,4R)-3-(2-phenyl-1H-... 1 18
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 1
D(2) dopamine receptor ligand SureCN10575660 family 1 1
D(1A) dopamine receptor and D(3) dopamine receptor ligand RU-2... 3 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
CGMP-dependent protein kinase inhibitor AGN-PC-0761UG family 1 2
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 7
9-methyl-1,2,3,5,6,7-hexahydro-3a,6-epoxy[1,4]oxazepino[2,3,4-... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00171624 CHEMBL159423 Bioactive 2-[[4-(2-benzhydryloxyethyl)piperazin-1-yl]methyl]-1H-indole
CFAMM00171627 CHEMBL160073 Bioactive 2-[[4-[2-[bis(4-fluorophenyl)methoxy]ethyl]piperazin-1-yl]methyl]-1H-indole
CFAMM00171626 CHEMBL538405 Bioactive 2-[[4-[2-[bis(4-fluorophenyl)methoxy]ethyl]piperidin-1-yl]methyl]-1H-indole
CFAMM00171615 DNCL002952 Clinical Trial Drug GRT 6005/06

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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