CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD790
Family Name MK-6096 family
No. of Seeds 3 No. of Other Members 69
Family Centroid CFAMM00171709 Functional Category Clinical Trial Drug
Superfamily MK-6096 Superfamily
Class Class 1305

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Smoothened homolog Inhibitor LDE225 Family 3 76
JAK Inhibitor Momelotinib Family 33 83
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 37
Serine/threonine-protein kinase Chk1 Inhibitor N-(5,6-diphenyl... 9 100
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lyn and Tyrosine-protein kinase Lck in... 1 6
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
Gonadotropin-releasing hormone receptor ligand AGN-PC-034WF4 f... 8 23
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Histamine H3 receptor ligand SureCN7251693 family 3 1
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Metabotropic glutamate receptor 5 ligand AGN-PC-09QLD2 family 1 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
Glucose-dependent insulinotropic receptor and Potassium voltag... 4 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 2 3
Renin inhibitor [2-(2,6-dimethylphenoxy)-6-methoxy-1-phenylpyr... 1 0
Adenosine receptor A3 ligand CHEMBL1834703 family 2 1
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 3 0
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Vascular endothelial growth factor receptor 1 and Receptor-typ... 2 11
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Histamine H3 receptor ligand N-[[2-[2-[(2R)-2-methylpyrrolidin... 4 1
Vascular endothelial growth factor receptor 1 ligand CHEMBL197... 1 2
ALK tyrosine kinase receptor and Insulin-like growth factor 1 ... 1 4
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Epidermal growth factor receptor ligand SureCN4454332 family 18 5
Activated CDC42 kinase 1 inhibitor 6-[4-(2-morpholin-4-ylethox... 7 1
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 3 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Vascular endothelial growth factor receptor 2 and Platelet-der... 16 11
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Adenosine receptor A1 ligand ethyl 1-(2-chloro-2-phenylethyl)-... 5 1
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0DB8TJ family 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Tyrosine-protein kinase JAK2 inhibitor 4-[[8-(4-methoxyphenyl)... 2 1
Orexin receptor type 1 and Orexin receptor type 2 ligand (1R,2... 6 1
Growth hormone secretagogue receptor type 1 and Muscarinic ace... 3 9
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Metabotropic glutamate receptor 5 and Cytochrome P450 3A4 liga... 3 7
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Ephrin type-A receptor 3 and Tyrosine-protein kinase Fgr ligan... 1 3
Hepatocyte growth factor receptor ligand AGN-PC-00AG7Q family 1 10
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 1
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Gonadotropin-releasing hormone receptor ligand 4-[2-[(2S)-azet... 1 0
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 4
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Transient receptor potential cation channel subfamily V member... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-071H3F fa... 3 0
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 19 2
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
Neuropeptide Y receptor type 5 ligand SureCN2658856 family 6 0
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1
Tyrosine-protein kinase Lck inhibitor AGN-PC-07R5ZB family 4 3
Sodium channel protein type 9 subunit alpha and Potassium volt... 1 1
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 2 0
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-0766EI f... 1 0
Vascular endothelial growth factor receptor 2 and Serine/threo... 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00171716 CHEMBL245948 Bioactive SureCN1264837
CFAMM00171686 CHEMBL394694 Bioactive SureCN1265201
CFAMM00171709 DNCL002958 Clinical Trial Drug MK-6096

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26406 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543