CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD80
Family Name Serine/threonine-protein kinase PLK1 Inhibitor HMN-214 Family
No. of Seeds 3 No. of Other Members 58
Family Centroid CFAMM00133305 Functional Category Clinical Trial Drug
Superfamily Serine/threonine-protein kinase PLK1 Inhibitor HMN-214 Superfamily
Class Class 198

Cousin Family NamesSeedsMembers
Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Family 48 78
Melatonin receptor type 1A Ligand Melatonin Family 20 988
72 kDa type IV collagenase and Interstitial collagenase Inhibi... 5 81
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor GSK2... 15 18
Prostaglandin E2 receptor EP2 subtype Ligand CP-533536 Family 2 9
Apricoxib family 8 77
Indeglitazar family 3 39
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Prostaglandin G/H synthase 2 Inhibitor 5-methoxy-2-(4-(methyls... 3 12
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
5-hydroxytryptamine receptor 6 ligand N-[3-[[(2R)-1-methylpyrr... 6 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
Cannabinoid receptor 2 ligand AGN-PC-09M5M9 family 1 0
5-hydroxytryptamine receptor 6 ligand SureCN5502542 family 4 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 15
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Progesterone receptor and Androgen receptor ligand AGN-PC-04QD... 1 0
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Collagenase 3 and 72 kDa type IV collagenase inhibitor N-hydro... 3 25
Disintegrin and metalloproteinase domain-containing protein 17... 44 12
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 1 3
Collagenase 3 and Interstitial collagenase inhibitor (2R,5R)-N... 4 1
5-hydroxytryptamine receptor 6 ligand SureCN5253197 family 4 2
5-hydroxytryptamine receptor 6 ligand 9-(4-methoxyphenyl)sulfo... 1 0
5-hydroxytryptamine receptor 6 ligand 1-(2-bromo-4-methoxyphen... 2 1
Endothelin-1 receptor and Endothelin B receptor ligand AGN-PC-... 11 10
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Matrix metalloproteinase-9 and Collagenase 3 inhibitor N-hydro... 6 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor AGN-... 1 0
Collagenase 3 and Disintegrin and metalloproteinase domain-con... 1 2
Neutrophil collagenase and Stromelysin-1 inhibitor (3R)-N-hydr... 2 0
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 5 13
Matrix metalloproteinase-9 and Collagenase 3 inhibitor AGN-PC-... 1 3
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 0
Collagenase 3 and Stromelysin-1 inhibitor (2R,4S)-N-hydroxy-4-... 1 0
Matrix metalloproteinase-9 and Collagenase 3 inhibitor N-hydro... 2 1
5-hydroxytryptamine receptor 6 ligand 1-[9-(2,5-dimethoxypheny... 2 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-075BWR family 1 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 0
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 3 3
Oxytocin receptor and Vasopressin V1a receptor ligand 4-methox... 9 8
Prostaglandin E2 receptor EP3 subtype ligand (E)-3-(1-methyl-4... 14 12
5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 9 0
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 2 3
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 2 3
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Matrix metalloproteinase-9 and Collagenase 3 inhibitor 5-bromo... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00133341 CHEMBL2048749 Bioactive (E)-N-hydroxy-3-[1-(4-methoxyphenyl)sulfonylindol-5-yl]prop-2-enamide
CFAMM00133305 DCL000128 Clinical Trial Drug HMN-214
CFAMM00133331 DNC002836 Investigative Drug WAY-151693

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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