CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD81
Family Name B2 bradykinin receptor Ligand Icatibant Family
No. of Seeds 9 No. of Other Members 27
Family Centroid CFAMM00133378 Functional Category Clinical Trial Drug
Superfamily B2 bradykinin receptor Ligand Icatibant Superfamily
Class Class 645

Cousin Family NamesSeedsMembers
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
B2 bradykinin receptor Ligand Labradimil Family 1 1
Thymosin Beta-4 family 8 30
B1 bradykinin receptor Ligand B-9858 Family 4 14
B1 bradykinin receptor Ligand B-9958 Family 6 4
Nociceptin receptor Ligand Fggftgcrkscrk Family 10 0
B1 bradykinin receptor and B2 bradykinin receptor Ligand H-lys... 11 4
Calcitonin gene-related peptide type 1 receptor Ligand Fvptdvg... 8 8
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Prothrombin inhibitor (2S)-N-[(4-carbamimidoylthiophen-2-yl)me... 12 9
B2 bradykinin receptor ligand (2S)-2-[[(2S,3aS,7aS)-1-[(2R,4S)... 1 0
B2 bradykinin receptor ligand (2S)-2-[[(2S)-1-[(2R)-1-[(2S)-2-... 1 0
B2 bradykinin receptor ligand (2S)-2-[[(2S,3aS,7aS)-1-[(3R)-2-... 1 0
B2 bradykinin receptor ligand CHEMBL2028837 family 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00133386 CHEMBL3038094 Bioactive (2S)-2-[[2-[[(3R)-2-[(2S)-2-[[(2S)-2-[[2-[[(2S,4R)-1-[(2S)-1-[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]-4-hydroxypyrrolidine-2-carbonyl]amino]acetyl]amino]-3-thiophen-2-ylpropanoyl]amino]-3-hydroxypropanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]-cyclopentylamino]acetyl]amino]-5-(diaminomethylideneamino)pentanoic acid
CFAMM00133384 CHEMBL3038099 Bioactive (2S)-2-[[2-[[(3R)-2-[(2S)-2-[[(2S)-2-[[2-[[(2S,4R)-1-[(2S)-1-[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]-4-hydroxypyrrolidine-2-carbonyl]amino]acetyl]amino]-3-thiophen-2-ylpropanoyl]amino]-3-hydroxypropanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]-cyclohexylamino]acetyl]amino]-5-(diaminomethylideneamino)pentanoic acid
CFAMM00133377 CHEMBL2369940 Bioactive (2S)-2-[[(2S)-1-[(3R)-2-[(2S)-2-[[(2S)-2-[[2-[[(2S,5S)-1-[(2S)-1-[(2S)-2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]-5-hydroxypyrrolidine-2-carbonyl]amino]acetyl]amino]-3-thiophen-3-ylpropanoyl]amino]-3-hydroxypropanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
CFAMM00133363 CHEMBL3038106 Bioactive (2S)-2-[[2-[[(3R)-2-[(2S)-2-[[(2S)-2-[[2-[[(2R,4S)-1-[(2R,4S)-1-[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-4-hydroxypyrrolidine-2-carbonyl]-4-hydroxypyrrolidine-2-carbonyl]amino]acetyl]amino]-3-thiophen-2-ylpropanoyl]amino]-3-hydroxypropanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]-cyclohexylamino]acetyl]amino]-5-(diaminomethylideneamino)pentanoic acid
CFAMM00133369 CHEMBL3038100 Bioactive (2S)-2-[[2-[cyclohexyl-[(3R)-2-[(2S)-2-[[(2S)-2-[[2-[[(2R,4S)-1-[(2R)-1-[(2S)-5-(diaminomethylideneamino)-2-[5-(diaminomethylideneamino)pentanoylamino]pentanoyl]pyrrolidine-2-carbonyl]-4-hydroxypyrrolidine-2-carbonyl]amino]acetyl]amino]-3-thiophen-2-ylpropanoyl]amino]-3-hydroxypropanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoic acid
CFAMM00133378 DCL000131 Clinical Trial Drug Icatibant
CFAMM00133360 DNC011563 Investigative Drug (D)Arg-Arg-Pro-Hyp-Gly-Thi-Ser-(D)Tic-Tic-Arg
CFAMM00133358 DNC011571 Investigative Drug (D)Arg-Arg-Pro-Hyp-Gly-Thi-Cys-(D)Phe-Phe-Cys-Arg
CFAMM00133375 DNC011545 Investigative Drug (D)Arg-Arg-Pro-Hyp-Gly-Thi-Ser-(D)Tic-Aoc-Arg

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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