CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD813
Family Name PF-02545920 family
No. of Seeds 16 No. of Other Members 140
Family Centroid CFAMM00171963 Functional Category Clinical Trial Drug
Superfamily Fibroblast growth factor receptor Binder Superfamily
Class Class 1322

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Ibrutinib family 2 27
Fibroblast growth factor receptor Ligand LY2874455 Family 1 1
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Sodium channel protein type 4 subunit alpha Ligand 3-(4-phenox... 2 4
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YUW... 2 9
Sigma non-opioid intracellular receptor 1 ligand 1'-butyl-6-me... 23 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 10
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 5
Smoothened homolog inhibitor AGN-PC-088VBV family 1 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15681... 1 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 1
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 9 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Sigma non-opioid intracellular receptor 1 ligand 6-methoxy-1'-... 2 0
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Muscarinic acetylcholine receptor M3 ligand 3-fluoro-2-(3-pipe... 3 1
Glucocorticoid receptor ligand [(4aR,5S)-1-(4-fluorophenyl)-4a... 7 1
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Platelet-derived growth factor receptor beta and Receptor-type... 1 2
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
Metabotropic glutamate receptor 5 ligand SureCN4699900 family 1 5
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Serine/threonine-protein kinase B-raf inhibitor pyrrole-based ... 2 0
RAC-alpha serine/threonine-protein kinase inhibitor N-[(2S)-1-... 2 1
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Platelet-derived growth factor receptor beta and Macrophage co... 8 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand Piper... 3 14
Neuronal acetylcholine receptor subunit alpha-7 ligand 5-[6-[[... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 1
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 inhibi... 1 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Prostaglandin D2 receptor 2 ligand 2-[4-(difluoromethoxy)-2-et... 1 0
Estrogen receptor and Estrogen receptor beta ligand 4-[3-[4-(2... 1 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor AGN-... 2 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand 4-[1-... 1 0
Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dih... 1 5
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN4806204 f... 13 7
Serine/threonine-protein kinase Chk1 and Aurora kinase B inhib... 14 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
Renin inhibitor SureCN6043852 family 2 0
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 3 0
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 2 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
B2 bradykinin receptor ligand SureCN13145573 family 7 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor AGN-PC... 2 0
RAC-alpha serine/threonine-protein kinase and Rho-associated p... 1 0
Sodium channel protein type 4 subunit alpha ligand AGN-PC-006B... 3 2
Adenosine receptor A1 ligand 4-amino-2-phenyl-3H-pyrazolo[3,4-... 1 0
Acetylcholinesterase and Cholinesterase inhibitor P10358 family 2 0
Thyroid hormone receptor beta and TGF-beta receptor type-1 lig... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00171937 CHEMBL1915736 Bioactive 2-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]-3-methoxypyridine
CFAMM00172096 CHEMBL554906 Bioactive AGN-PC-00BAQG
CFAMM00171976 CHEMBL562318 Bioactive PF-2545920
CFAMM00172081 CHEMBL565237 Bioactive substituted pyrazole, 11
CFAMM00171982 CHEMBL562513 Bioactive TP-10
CFAMM00172074 CHEMBL1642569 Bioactive AGN-PC-09QKHA
CFAMM00171935 CHEMBL1915733 Bioactive 3-methoxy-2-[[4-[4-pyridin-4-yl-1-(2,2,2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]pyridine
CFAMM00172100 CHEMBL1915747 Bioactive 2-[[4-[1-(2-fluoranylethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]quinoline
CFAMM00171972 CHEMBL560378 Bioactive substituted pyrazole, 10
CFAMM00172092 CHEMBL550155 Bioactive substituted pyrazole, 12
CFAMM00172085 CHEMBL1915725 Bioactive 2-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]-3,5-dimethylpyridine
CFAMM00171962 CHEMBL1915742 Bioactive 2-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]-6-methoxypyridine
CFAMM00172084 CHEMBL1915726 Bioactive 2-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]-5-methoxypyridine
CFAMM00171961 CHEMBL1915746 Bioactive 2-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]-3,4,5-trimethylpyridine
CFAMM00172083 CHEMBL1915727 Bioactive 2-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]-6-methylpyridine
CFAMM00171963 DNCL003127 Clinical Trial Drug PF-02545920

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45918 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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