CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD815
Family Name Zicronapine family
No. of Seeds 43 No. of Other Members 62
Family Centroid CFAMM00172141 Functional Category Clinical Trial Drug
Superfamily Zicronapine Superfamily
Class Class 1324

Cousin Family NamesSeedsMembers
Serotonin re-uptake inhibitor tetralin derivative Sertraline f... 12 118
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Sibu... 7 127
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Nuclear receptor subfamily 1 group I member 3 ligand piperazin... 3 82
Dopamine receptor ligand norcamphene derivative Fencamfamine F... 3 41
Amine oxidase [flavin-containing] B Inhibitor Rasagiline Family 2 11
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Substance-P receptor Ligand Orvepitant Family 11 46
Dopamine reuptake and Noradrenergic re-uptake Inhibitor Dov 21... 16 89
5-hydroxytryptamine receptor 2C Ligand Lorcaserin Family 8 38
Substance-P receptor Ligand Vestipitant Family 14 137
Sigma non-opioid intracellular receptor 1 Ligand Dimemorfan Fa... 5 15
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 3 7
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 6 7
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
Dipeptidyl peptidase 4 Inhibitor 2-(2-chlorophenyl)-2-morpholi... 2 34
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Dipeptidyl peptidase 4 Inhibitor 1-benzyl-4-(2,4-dichloropheny... 2 10
Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Sodium-dependent serotonin transporter Inhibitor Irindalone Fa... 16 9
Sodium-dependent serotonin transporter Inhibitor Tefludazine F... 8 9
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 5 6
Sigma non-opioid intracellular receptor 1 ligand CHEMBL101300 ... 2 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
Sigma non-opioid intracellular receptor 1 ligand NCI60_038428 ... 5 9
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 4 13
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 7 9
Sodium-dependent serotonin transporter and Sodium-dependent no... 12 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 7 and Sodium-dependent serotonin ... 5 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 7 1
Vesicular acetylcholine transporter inhibitor (3R,4R)-1-[(3-io... 17 20
D(1A) dopamine receptor and D(2) dopamine receptor ligand Sure... 2 0
D(1A) dopamine receptor and 5-hydroxytryptamine receptor 2A li... 2 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 18 4
Pyruvate kinase PKM and Huntingtin inhibitor CHEMBL1455935 family 1 3
Sigma non-opioid intracellular receptor 1 ligand 1-[2-(3,4-dic... 8 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 5 6
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0
Transporter and Sodium-dependent dopamine transporter inhibito... 3 0
Transporter and Sodium-dependent serotonin transporter inhibit... 4 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 6 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Sodium-dependent dopamine transporter inhibitor N-[[(1S,3S,4R,... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 3
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 12
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 1
Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 1
D(1A) dopamine receptor and D(3) dopamine receptor ligand 2-[4... 1 0
5-hydroxytryptamine receptor 1A ligand SureCN8901985 family 1 0
Histamine H3 receptor ligand 2-benzyl-4-[4-(2-pyrrolidin-1-yle... 8 4
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 7
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Sodium-dependent serotonin transporter and Transporter inhibit... 2 8
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
D(1A) dopamine receptor and D(2) dopamine receptor ligand A314... 3 1
Sigma non-opioid intracellular receptor 1 ligand NCI60_039912 ... 2 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand AGN-... 2 1
C-C chemokine receptor type 5 ligand 1-[[(3S,4S)-1-(cyclohexyl... 1 0
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 2 6
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 9
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 1
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0
Nociceptin receptor and Mu-type opioid receptor ligand 2-[2-[(... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Prostaglandin E synthase inhibitor AGN-PC-09QMEJ family 2 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 10
Nociceptin receptor and Mu-type opioid receptor ligand (NE)-N-... 1 0
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 1 0
Glucose-6-phosphatase inhibitor SureCN8498194 family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00172219 CHEMBL96362 Bioactive AGN-PC-00LFMM
CFAMM00172218 CHEMBL422067 Bioactive AGN-PC-04SEVV
CFAMM00172144 CHEMBL1743782 Bioactive (6S,10bR)-6-(4-chlorophenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline;hydrobromide
CFAMM00172170 CHEMBL136932 Bioactive AGN-PC-01ZH7M
CFAMM00172191 CHEMBL136340 Bioactive AGN-PC-01ZH7L
CFAMM00172217 CHEMBL137960 Bioactive SureCN933996
CFAMM00172155 CHEMBL335155 Bioactive SureCN8115878
CFAMM00172183 CHEMBL136822 Bioactive AGN-PC-01ZH7V
CFAMM00172209 CHEMBL344206 Bioactive AGN-PC-00GAVH
CFAMM00172208 CHEMBL285506 Bioactive SureCN10375263
CFAMM00172147 CHEMBL136630 Bioactive AGN-PC-01ZH7D
CFAMM00172173 CHEMBL344426 Bioactive AGN-PC-01ZH7H
CFAMM00172201 CHEMBL555549 Bioactive AGN-PC-07BYWK
CFAMM00172146 CHEMBL1743786 Bioactive (6S,10bR)-9-chloro-6-phenyl-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline;hydrobromide
CFAMM00172159 CHEMBL540617 Bioactive (10bS)-6-(4-chlorophenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline;hydrobromide
CFAMM00172213 CHEMBL35013 Bioactive (6S,10bR)-9-chloro-6-(4-chlorophenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline
CFAMM00172165 CHEMBL343922 Bioactive AGN-PC-01ZH7X
CFAMM00172145 CHEMBL136260 Bioactive AGN-PC-00GBHW
CFAMM00172193 CHEMBL1744119 Bioactive (Z)-but-2-enedioic acid;1-[2-[4-(5-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl)piperazin-1-yl]ethyl]-3-propan-2-ylimidazolidin-2-one
CFAMM00172141 DNCL003136 Clinical Trial Drug Zicronapine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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