CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD816
Family Name CORT-108297 family
No. of Seeds 46 No. of Other Members 44
Family Centroid CFAMM00172262 Functional Category Clinical Trial Drug
Superfamily CORT-108297 Superfamily
Class Class 1325

Cousin Family NamesSeedsMembers
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Opioid receptor ligand opiate Levorphanol Family 18 537
D(1A) dopamine receptor Ligand Fenoldopam Family 4 78
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Eptazocine Hbr family 6 8
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
Amine oxidase [flavin-containing] B Inhibitor 5-hydroxy-n-prop... 3 5
Acetylcholinesterase and Cholinesterase Inhibitor N,n'-(1',10'... 12 8
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Sodium-dependent dopamine transporter and Sodium-dependent nor... 10 9
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 4
D(1A) dopamine receptor Ligand 5-(2-amino-ethyl)-2-chloro-phen... 1 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TF5... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 8
D(2) dopamine receptor and D(1A) dopamine receptor ligand (2R,... 3 2
D(1A) dopamine receptor ligand (5S)-5-(4-azidophenyl)-8-iodo-3... 2 0
D(1A) dopamine receptor ligand (5R)-8-bromo-3-methyl-5-phenyl-... 6 15
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
D(2) dopamine receptor and D(1A) dopamine receptor ligand AGN-... 1 1
D(1A) dopamine receptor and D(2) dopamine receptor ligand (2R,... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Transporter and Sodium-dependent serotonin transporter inhibit... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
5-hydroxytryptamine receptor 2C ligand (3aS,4R,8bS)-6-chloro-7... 1 4
Sodium-dependent dopamine transporter and Transporter inhibito... 4 0
D(1A) dopamine receptor and D(1B) dopamine receptor ligand Sur... 6 6
D(1A) dopamine receptor and D(2) dopamine receptor ligand (5R)... 2 0
D(1A) dopamine receptor and D(1B) dopamine receptor ligand (6a... 1 0
D(1A) dopamine receptor and D(1B) dopamine receptor ligand met... 1 1
D(1A) dopamine receptor and D(1B) dopamine receptor ligand N-[... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00172228 CHEMBL1256645 Bioactive R(+)-SCH-23390 hydrochloride
CFAMM00172278 CHEMBL34170 Bioactive 120685-95-2
CFAMM00172291 CHEMBL599116 Bioactive SureCN13900271
CFAMM00172243 CHEMBL307790 Bioactive SureCN7277001
CFAMM00172271 CHEMBL599134 Bioactive (6aS,13bS)-11-chloro-4-[(E)-methoxyiminomethyl]-7-methyl-5,6,6a,8,9,13b-hexahydronaphtho[1,2-a][3]benzazepin-12-ol
CFAMM00172235 CHEMBL303012 Bioactive (5R)-8-chloro-3-methyl-5-(4-methylphenyl)-1,2,4,5-tetrahydro-3-benzazepin-7-ol
CFAMM00172221 CHEMBL304535 Bioactive (5R)-8-chloro-3-methyl-5-(3-methylphenyl)-1,2,4,5-tetrahydro-3-benzazepin-7-ol
CFAMM00172277 CHEMBL131054 Bioactive AGN-PC-0A3YUW
CFAMM00172227 CHEMBL303993 Bioactive (1S)-6-chloro-2-methyl-1-phenyl-3,4-dihydro-1H-isoquinolin-7-ol
CFAMM00172290 CHEMBL130851 Bioactive AGN-PC-00Q3MF
CFAMM00172283 CHEMBL1814790 Bioactive SCH 23390 maleate
CFAMM00172234 CHEMBL600083 Bioactive SureCN13900266
CFAMM00172296 CHEMBL2158641 Bioactive (5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol;(Z)-2,3-dihydroxybut-2-enedioic acid
CFAMM00172276 CHEMBL422796 Bioactive AGN-PC-00Q3MN
CFAMM00172233 CHEMBL545477 Bioactive (6R,8S)-3-chloro-6-(dimethylamino)-8-phenyl-5,6,7,8-tetrahydronaphthalen-2-ol;hydrochloride
CFAMM00172247 CHEMBL13632 Bioactive AGN-PC-002XW7
CFAMM00172261 CHEMBL604127 Bioactive SureCN13901034
CFAMM00172288 CHEMBL2114388 Bioactive 8-chloro-5-(4-iodanylphenyl)-3-methyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol
CFAMM00172267 CHEMBL597100 Bioactive (6aS,13bS)-11-chloro-4-(3,5-difluorophenyl)-7-methyl-5,6,6a,8,9,13b-hexahydronaphtho[1,2-a][3]benzazepin-12-ol
CFAMM00172224 CHEMBL604176 Bioactive (6aS,13bS)-11-chloro-4-[4-(hydroxymethyl)phenyl]-7-methyl-5,6,6a,8,9,13b-hexahydronaphtho[1,2-a][3]benzazepin-12-ol
CFAMM00172287 CHEMBL598105 Bioactive 3-[(6aS,13bS)-11-chloro-12-hydroxy-7-methyl-5,6,6a,8,9,13b-hexahydronaphtho[1,2-a][3]benzazepin-4-yl]benzonitrile
CFAMM00172301 CHEMBL336532 Bioactive AGN-PC-00Q3MO
CFAMM00172293 CHEMBL1628675 Bioactive (5R)-8-chloro-5-phenyl-3-(tritritiomethyl)-1,2,4,5-tetrahydro-3-benzazepin-7-ol
CFAMM00172231 CHEMBL340855 Bioactive AGN-PC-00Q3MQ
CFAMM00172245 CHEMBL444321 Bioactive SureCN14502337
CFAMM00172259 CHEMBL128649 Bioactive AGN-PC-00Q3MR
CFAMM00172286 CHEMBL598104 Bioactive (6aS,13bS)-11-chloro-4-(3-fluorophenyl)-7-methyl-5,6,6a,8,9,13b-hexahydronaphtho[1,2-a][3]benzazepin-12-ol
CFAMM00172223 CHEMBL59139 Bioactive AGN-PC-002JX1
CFAMM00172300 CHEMBL596622 Bioactive (5R)-8-chloro-5-[4-[(cyclobutylamino)methyl]phenyl]-3-methyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol
CFAMM00172265 CHEMBL543704 Bioactive AGN-PC-07C0MX
CFAMM00172230 CHEMBL545249 Bioactive AGN-PC-07BZEZ
CFAMM00172237 CHEMBL604732 Bioactive (6aS,13bS)-11-chloro-4-[(E)-hydroxyiminomethyl]-7-methyl-5,6,6a,8,9,13b-hexahydronaphtho[1,2-a][3]benzazepin-12-ol
CFAMM00172262 DNCL003148 Clinical Trial Drug CORT-108297
CFAMM00172222 DNC001307 Investigative Drug SCH-23390

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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