CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Gonadotropin-releasing hormone Inhibitor ASP3550 Family
No. of Seeds 33 No. of Other Members 60
Family Centroid CFAMM00172392 Functional Category Clinical Trial Drug
Superfamily Gonadotropin-releasing hormone Inhibitor ASP3550 Superfamily
Class Class 980

Cousin Family NamesSeedsMembers
Gonadotropin-releasing hormone receptor Ligand decapeptide ana... 9 162
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
Growth hormone receptor Ligand EP-51216 Family 34 390
ABC294640 family 5 75
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Gonadotropin-releasing hormone receptor Ligand Azaline B Family 12 0
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Gonadotropin-releasing hormone receptor Ligand [d-gln3,d-ncy(s... 8 0
Gonadotropin-releasing hormone receptor Ligand [d-ncy(methyl)4... 32 0
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Pol polyprotein inhibitor penicillin deriv. 40 family 2 4
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Coagulation factor X and Prothrombin inhibitor SureCN8243313 f... 10 8
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Gonadotropin-releasing hormone receptor ligand (3S)-3-[[(2S)-2... 5 0
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 1 0


External ID

Functional Category

Molecule Name

CFAMM00172450 CHEMBL405273 Bioactive CHEMBL405273
CFAMM00172449 CHEMBL402683 Bioactive CHEMBL402683
CFAMM00172399 CHEMBL264781 Bioactive CHEMBL264781
CFAMM00172366 CHEMBL415606 Bioactive Degarelix
CFAMM00172406 CHEMBL412500 Bioactive CHEMBL412500
CFAMM00172441 CHEMBL265879 Bioactive CHEMBL265879
CFAMM00172426 CHEMBL444381 Bioactive CHEMBL444381
CFAMM00172403 CHEMBL264090 Bioactive CHEMBL264090
CFAMM00172456 CHEMBL374747 Bioactive CHEMBL374747
CFAMM00172392 DNCL003339 Clinical Trial Drug ASP3550
CFAMM00172349 DNC006646 Investigative Drug [4Aph(CO-NH-OCH3)5,D-4Aph(CO-NH-OCH3)6]degarelix
CFAMM00172327 DNC006654 Investigative Drug [D-Dab(CO-NH-OCH3)3]degarelix
CFAMM00172417 DNC007370 Investigative Drug [Ncy(2-naphthyl)1]acyline
CFAMM00172431 DNC007360 Investigative Drug [Ncy(SO,methyl)10]acyline
CFAMM00172326 DNC006655 Investigative Drug [D-Dab(CO-NH-OH)3]degarelix
CFAMM00172430 DNC007365 Investigative Drug [Ncy(isopropyl)7]acyline
CFAMM00172367 DNC006650 Investigative Drug [4Aph(CO-(C2H4O)3-C2H4-NH-CO-NH-OCH3)5]degarelix
CFAMM00172325 DNC006656 Investigative Drug [D-Dap(CO-NH-OH)3]degarelix
CFAMM00172429 DNC007364 Investigative Drug [Ncy(SO,isopropyl)7]acyline
CFAMM00172336 DNC006658 Investigative Drug [D-Dap(CO-NH-OCH3)3]degarelix
CFAMM00172324 DNC006657 Investigative Drug ACYLINE
CFAMM00172330 DNC006651 Investigative Drug [4Aph(CO-NH-(C2H4O)2-C2H5)5]degarelix
CFAMM00172390 DNC007358 Investigative Drug [D-Ncy(SO,methyl)10]acyline
CFAMM00172344 DNC006649 Investigative Drug [D-4Aph(CO-NH-OH)6]degarelix
CFAMM00172376 DNC005341 Investigative Drug DEGARELIX
CFAMM00172434 DNC007363 Investigative Drug [D-Ncy(isopropyl)7]acyline
CFAMM00172329 DNC006652 Investigative Drug [4Aph(CO-NH-OCH3)5]degarelix
CFAMM00172389 DNC007359 Investigative Drug [D-Ncy(methyl)10] acyline
CFAMM00172433 DNC007362 Investigative Drug [D-Ncy(SO,isopropyl)7]acyline
CFAMM00172343 DNC006648 Investigative Drug [D-4Aph(CO-NH-OCH3)6]degarelix
CFAMM00172328 DNC006653 Investigative Drug [4Aph(CO-NH-OH)5]degarelix
CFAMM00172350 DNC006647 Investigative Drug [D-4Aph(CO-NH-(C2H4O)2-C2H5)6]degarelix
CFAMM00172432 DNC007361 Investigative Drug [Ncy(methyl)10]acyline

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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