CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD823
Family Name Dual specificity mitogen-activated protein kinase kinase Inhibitor Mek-inhibitor Family
No. of Seeds 7 No. of Other Members 69
Family Centroid CFAMM00172543 Functional Category Clinical Trial Drug with Human Metabolite & Natural Product
Superfamily Dual specificity mitogen-activated protein kinase kinase Inhibitor Mek-inhibitor Superfamily
Class Class 1330

Cousin Family NamesSeedsMembers
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Voltage-gated sodium channel Ligand Oxcarbazepine Family 1 4
Tumor necrosis factor Inhibitor Thalidomide Family 3 50
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
DNA Binder Procarbazine Family 8 358
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Serum albumin Inhibitor Ebselen Family 3 62
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Motilin receptor Ligand GSK962040 Family 30 457
Tumor necrosis factor Inhibitor Pirfenidone Family 2 38
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Dual specificity mitogen-activated protein kinase kinase Inhib... 8 4
K-604 family 4 71
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Pan-DAC Inhibitor AR-42 Family 21 153
Amonafide family 3 35
Intedanib family 7 54
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin-neurophysin 2-copeptin Inhibitor Niravoline Family 7 45
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
5-hydroxytryptamine receptor 4 Ligand TD-5108 Family 21 24
Fumarate reductase flavoprotein subunit Inhibitor 2-heptyl-4-h... 3 16
Urokinase-type plasminogen activator Inhibitor 6-(n-phenylcarb... 2 11
Liver carboxylesterase 1 Inhibitor 1-methyl-1h-indole-2,3-dion... 10 35
Epidermal growth factor receptor Ligand 5,6-bis-p-tolylamino-i... 2 2
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 19 88
Potassium voltage-gated channel subfamily A member 5 Ligand N-... 8 32
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 4-methyl-5,6... 3 12
Integrin beta-3 Inhibitor L-767679 Family 3 6
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Cruzipain Inhibitor 5-chloro-1-(4-chloro-benzyl)-1h-indole-2,3... 3 13
Integrin beta-3 Inhibitor L-750034 Family 7 38
Integrin beta-3 Inhibitor SB-208651 Family 9 28
Integrin beta-3 Inhibitor Lotrafiban Family 5 1
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
MO15-related protein kinase Pfmrk Inhibitor 5-nitro-1h-indole-... 1 4
Fatty acid-binding protein and C-X-C chemokine receptor type 1... 1 6
Poly [ADP-ribose] polymerase 1 Inhibitor 8-amino-6h,11h-indeno... 3 9
Transient receptor potential cation channel subfamily V member... 6 33
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4... 2 17
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 1 9
Aurora kinase B Inhibitor Hesperadin Family 1 1
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Liver carboxylesterase 1 Inhibitor 6-bromo-5-methyl-1h-indole-... 1 0
Liver carboxylesterase 1 Inhibitor 4-chloro-1h-indole-2,3-dion... 3 7
Liver carboxylesterase 1 Inhibitor 7-chloro-1h-indole-2,3-dion... 6 5
Liver carboxylesterase 1 Inhibitor 7-(trifluoromethyl)-1h-indo... 1 1
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Oxysterols receptor LXR-alpha Ligand 2-(2-phenethylphenyl)isoi... 4 7
Transient receptor potential cation channel subfamily V member... 1 5
Progesterone receptor Ligand 3-(3,3-dimethyl-2-oxoindolin-5-yl... 2 10
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor Benz... 3 12
Phospholipase D1 Inhibitor Halopemide Family 17 111
M-phase inducer phosphatase 1 Inhibitor (z)-2-(1-decyl-2-oxoin... 2 2
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 1 1
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Telomerase reverse transcriptase Inhibitor 2,7-bis[2-(piperidi... 6 8
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 12
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Muscarinic acetylcholine receptor M5 Ligand VU0119498 Family 1 3
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 9 7
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 9h-bet... 1 1
Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-a... 1 15
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(3-cyanophe... 7 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
D(4) dopamine receptor ligand AGN-PC-074VC9 family 2 3
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Vasopressin V1a receptor ligand AGN-PC-074VJP family 3 1
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEDE family 7 17
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 4 8
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Cathepsin K and Cathepsin B inhibitor AGN-PC-01Z23J family 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 7 5
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 4
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
C-C chemokine receptor type 3 ligand SureCN6703027 family 2 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 5
Acetylcholinesterase inhibitor CHEMBL1651130 family 2 3
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 10 0
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 53
Acetylcholinesterase inhibitor 2-[2-(1-benzylpiperidin-4-yl)et... 2 9
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 6 5
Thyroid hormone receptor beta and DNA-(apurinic or apyrimidini... 1 0
Sigma non-opioid intracellular receptor 1 ligand 2-(2-nitrophe... 2 5
Hypoxia-inducible factor 1-alpha and Ubiquitin carboxyl-termin... 1 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Prelamin-A/C inhibitor CHEMBL1547148 family 1 8
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
Cellular tumor antigen p53 inhibitor CHEMBL1554992 family 1 0
D(2) dopamine receptor and D(3) dopamine receptor ligand 1,1-d... 2 7
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 5 2
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 8 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 24 11
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 3
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 2 4
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Mitogen-activated protein kinase 14 inhibitor 4-chloro-N-cyclo... 2 0
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 8 1
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-3-... 2 0
Kappa-type opioid receptor ligand N-methyl-N-[(1S)-2-pyrrolidi... 3 17
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
C-C chemokine receptor type 3 and Sodium-dependent serotonin t... 12 2
Delta-type opioid receptor and Potassium voltage-gated channel... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Neuronal acetylcholine receptor subunit alpha-7 ligand 2,7-bis... 2 1
Neuronal acetylcholine receptor subunit alpha-7 ligand 2,7-bis... 3 2
Histamine H3 receptor ligand SureCN3058680 family 4 0
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
Bifunctional epoxide hydrolase 2 inhibitor 1-(3-acetylphenyl)-... 1 3
Substance-P receptor and Potassium voltage-gated channel subfa... 5 0
D(2) dopamine receptor and Potassium voltage-gated channel sub... 1 1
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 2 17
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(cyanomethyl)-... 1 6
ALK tyrosine kinase receptor ligand 4-fluoro-N-[6-(piperidin-1... 10 7
C-C chemokine receptor type 3 ligand 1-(3-acetylphenyl)-3-[3-[... 9 1
Inosine-5'-monophosphate dehydrogenase 2 inhibitor SureCN32339... 2 2
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
Cannabinoid receptor 2 ligand 1-adamantyl-(5-fluoro-2,3-dihydr... 4 7
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 1
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Histamine receptor H3 ligand N-[2-methyl-4-[(3S)-3-[(2S)-2-met... 10 7
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Coagulation factor X inhibitor N-(4-chlorophenyl)-2-[[4-(2-oxo... 2 0
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
5-hydroxytryptamine receptor 7 ligand 7-chloro-3-[4-[4-(4-chlo... 2 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
5-hydroxytryptamine receptor 7 ligand 2-[4-[4-(2-oxo-1,3,4,5-t... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 7 12
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[5-... 3 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Protease and Replicase polyprotein 1a inhibitor AC1LALLS family 1 0
C-C chemokine receptor type 3 ligand AGN-PC-075BAT family 1 0
Beta-secretase 1 and Beta-secretase 2 inhibitor AC1N6ZLA family 1 0
Dipeptidyl peptidase 4 inhibitor 4-[[(3S,5S)-5-[(2S)-2-cyanopy... 4 12
Vascular endothelial growth factor receptor 2 ligand isoindoli... 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
Histone deacetylase 6 and Histone deacetylase 2 inhibitor 4-[[... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
72 kDa type IV collagenase and Disintegrin and metalloproteina... 1 5
Vascular endothelial growth factor receptor 2 ligand SureCN578... 1 2
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-009EMK... 2 1
5-hydroxytryptamine receptor 4 ligand 2-oxo-N-[(1R,5S)-8-(2-pi... 13 5
D(1A) dopamine receptor and D(3) dopamine receptor ligand 1-[4... 1 0
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-[2-(1-hydroxy-3... 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 3
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
C-C chemokine receptor type 5 ligand AC1MHP8Y family 1 0
Kappa-type opioid receptor ligand 2-[2-[bis(methylsulfonyl)ami... 2 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Tyrosine-protein kinase ITK/TSK and Mast/stem cell growth fact... 1 0
Glucose-dependent insulinotropic receptor ligand AGN-PC-04UO8L... 2 2
Caspase-3 and Caspase-7 inhibitor AGN-PC-00BUR6 family 2 1
Caspase-3 inhibitor Benzamide, 3-nitro-N-(1,2,3,4-tetrahydro-1... 2 3
Caspase-3 inhibitor SureCN12857739 family 1 1
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide de... 2 4
C5a anaphylatoxin chemotactic receptor 1 ligand SureCN12047568... 1 1
Protein farnesyltransferase subunit beta and Protein farnesylt... 4 13
Serine/threonine-protein kinase Chk1 inhibitor 6-oxo-9-(2-oxo-... 1 0
Multidrug resistance protein 1 inhibitor AGN-PC-07R6HU family 1 0
Telomerase reverse transcriptase inhibitor AGN-PC-07ZBGW family 2 0
Transient receptor potential cation channel subfamily A member... 1 0
Beta-lactamase inhibitor CHEMBL1406823 family 1 1
4,4,6,9-tetramethyl-6-phenyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]q... 5 1
ylspiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indo... 20 0
3-prop-2-enyl-1H-quinolin-4-one NP 6-amino-2-methylquinolin-4-... 5 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00172543 DNCL003395 Clinical Trial Drug MEK-Inhibitor
CFAMM00172539 DNC003821 Investigative Drug PD-172938
CFAMM00172472 DNC001385 Investigative Drug SU4984
CFAMM00172505 DNC009428 Investigative Drug (E)-6-Styrylisatin
CFAMM00172483 DNC003687 Investigative Drug 1-(2-Oxo-2-p-tolyl-ethyl)-1H-indole-2,3-dione
CFAMM00172510 DNC003779 Investigative Drug PD-172939
CFAMM00172525 DNC007548 Investigative Drug N-benzyl-9-oxo-9,10-dihydroacridine-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

46008 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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