CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD827
Family Name Tyrosine-protein kinase BTK Inhibitor CC-292 Family
No. of Seeds 6 No. of Other Members 10
Family Centroid CFAMM00172600 Functional Category Clinical Trial Drug
Superfamily Tyrosine-protein kinase BTK Inhibitor CC-292 Superfamily
Class Class 1334

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase A Inhibitor PF-03814735 Family 2 12
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
Vascular endothelial growth factor receptor 2 ligand urea deri... 3 9
Vascular endothelial growth factor receptor 2 ligand urea deri... 2 0
Mitogen-activated protein kinase 14 inhibitor SureCN3305171 fa... 1 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 7 1
Serine/threonine-protein kinase TBK1 and 3-phosphoinositide-de... 3 3
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 7
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00172587 CHEMBL1084546 Bioactive PF-562271
CFAMM00172594 CHEMBL513744 Bioactive AGN-PC-03I7WS
CFAMM00172586 CHEMBL487246 Bioactive AGN-PC-03I7UQ
CFAMM00172600 DNCL003452 Clinical Trial Drug CC-292
CFAMM00172595 DNC008520 Investigative Drug PF-228
CFAMM00172601 DND000005 Investigative Drug PF-562271

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27038 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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