CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD837
Family Name Eluxadoline family
No. of Seeds 4 No. of Other Members 85
Family Centroid CFAMM00172948 Functional Category Clinical Trial Drug with Natural Product
Superfamily Eluxadoline Superfamily
Class Class 546

Cousin Family NamesSeedsMembers
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Epidermal Growth Factor family 111 209
Insulin receptor Ligand Insulin, Porcine Family 61 205
Type-1 angiotensin II receptor Ligand Telmisartan Family 4 181
Type-1 angiotensin II receptor Ligand Eprosartan Family 36 176
Prothrombin Inhibitor Dabigatran Family 7 182
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Coagulation factor X Inhibitor Otamixaban Family 9 21
BIBT986 family 7 96
XL-888 family 16 85
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Putative histidine protein kinase Inhibitor Closantel 6 Family 1 2
Renin Inhibitor Enalkiren Family 56 44
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 1 8
5-hydroxytryptamine receptor 3A and Alpha-2A adrenergic recept... 31 24
Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 50 17
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-57893 Family 3 8
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Falcipain-2B Inhibitor FITC-LMNNAEHINQFYMFI Family 3 5
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Potassium voltage-gated channel subfamily H member 2 Ligand (1... 64 70
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Bombesin receptor subtype-3 ligand AGN-PC-07ZAKV family 13 23
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Pol polyprotein inhibitor AC1LAQE0 family 13 4
Integrin beta-3 and Integrin alpha-V inhibitor 2-[1-[2-[[4-(1H... 6 2
Thromboxane A2 receptor ligand AC1NSKJR family 13 42
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 11 22
Protein farnesyltransferase subunit beta and Protein farnesylt... 3 0
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 7 11
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 8
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 9
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 2
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 3
Microsomal triglyceride transfer protein large subunit inhibit... 7 4
Prothrombin inhibitor AGN-PC-09QMX4 family 1 4
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 3... 5 14
Platelet-activating factor receptor ligand SureCN7491834 family 28 15
Endothelin-1 receptor and Endothelin B receptor ligand SureCN9... 3 10
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Pol polyprotein inhibitor propan-2-yl N-[(2S)-1-[[(2S,3S,5R)-3... 6 2
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 29
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Histamine H3 receptor ligand AGN-PC-075YXY family 1 4
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Type-1 angiotensin II receptor ligand N-[2-(3-methoxyphenyl)et... 2 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 2 0
Coagulation factor X inhibitor AGN-PC-07C10A family 3 2
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Type-1A angiotensin II receptor ligand 2-[[2-butyl-3-[(4-carbo... 2 4
C-C chemokine receptor type 5 ligand AC1MHRXO family 5 1
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 7 15
Smoothened homolog inhibitor N-[4-methyl-3-(5-phenyl-1H-imidaz... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
5-hydroxytryptamine receptor 2B ligand SureCN1299437 family 6 7
Type-1 angiotensin II receptor ligand 2-butyl-3-[[4-(2-carboxy... 1 7
Orexin receptor type 2 and Orexin receptor type 1 ligand (2R)-... 4 1
Integrin beta-1 and Integrin alpha-4 inhibitor (5R)-5-[[(2R)-2... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Pol polyprotein and Protease inhibitor 161186-51-2 family 5 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Type-2 angiotensin II receptor and Type-1A angiotensin II rece... 2 24
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 1 1
Histamine H3 receptor ligand AGN-PC-075YVW family 1 2
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Neuropeptide Y receptor type 2 ligand CHEMBL411765 family 1 0
Thromboxane-A synthase inhibitor AGN-PC-00NE8C family 2 3
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Neuropeptide Y receptor type 5 ligand AGN-PC-077LX1 family 8 1
Type-1A angiotensin II receptor ligand 2-[4-[[2-butyl-5-(tert-... 1 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Serine/threonine-protein kinase Sgk1 inhibitor SureCN3774571 f... 2 18
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 4 4
Lysosomal Pro-X carboxypeptidase inhibitor 9H-fluoren-9-ylmeth... 1 1
Serine/threonine-protein kinase mTOR inhibitor 3-(cyclohexylme... 2 1
Sphingosine 1-phosphate receptor 1 ligand (2S)-2-[[2-(1H-imida... 4 7
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 1 0
Histone deacetylase 1 inhibitor (7S)-7-(5-naphthalen-2-yl-1H-i... 2 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 0
Putative NP ZINC40310254 Family 74 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00172902 CHEMBL2159120 Bioactive 3-[[[(2S)-2-amino-3-(4-carbamoyl-2,6-dimethylphenyl)propanoyl]-[(1S)-1-(5-phenyl-1H-imidazol-2-yl)ethyl]amino]methyl]benzoic acid
CFAMM00172954 CHEMBL13910 Bioactive N-[(2R)-1-[[(2R)-1-(4-butanoyl-4-phenylpiperidin-1-yl)-3-(4-methoxyphenyl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]benzamide
CFAMM00172903 CHEMBL2159121 Bioactive 5-[[[(2S)-2-amino-3-(4-carbamoyl-2,6-dimethylphenyl)propanoyl]-[(1S)-1-(5-phenyl-1H-imidazol-2-yl)ethyl]amino]methyl]-2-methoxybenzoic acid;hydrochloride
CFAMM00172948 DNCL003527 Clinical Trial Drug Eluxadoline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48712 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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