CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD838
Family Name Dapoxetine family
No. of Seeds 3 No. of Other Members 40
Family Centroid CFAMM00173013 Functional Category Clinical Trial Drug with Natural Product
Superfamily Histamine H1 receptor Ligand Doxepin Superfamily
Class Class 142

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Histamine H1 receptor Ligand Diphenhydramine Family 5 75
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 4 35
Substance-P receptor Ligand DA-5018 Family 14 73
Substance-P receptor Ligand Ezlopitant Family 10 207
5-hydroxytryptamine receptor 2A Ligand Pimavanserin Family 4 23
D(3) dopamine receptor Ligand U-99194A Family 7 33
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Dipeptidyl peptidase 4 Inhibitor (2-chloro-6-phenoxyphenyl)met... 17 24
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 33
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 6
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
Fatty-acid amide hydrolase 1 Inhibitor 3-(trifluoromethyl)phen... 3 0
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
Renin Inhibitor Ro-65-7219 Family 10 8
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 4
Tyrosinase Inhibitor 1-(3-phenoxypropyl)-4-(piperidin-1-yl)pip... 2 13
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Fatty-acid amide hydrolase 1 Inhibitor 8-phenyloctylcarbamic A... 12 1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Inhibitor 2... 1 9
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 5
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 4
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
Melatonin receptor type 1A ligand [7-methoxy-1-[2-(propanoylam... 3 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 7 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
D(3) dopamine receptor ligand S 14297 family 1 2
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 117
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Histamine H3 receptor ligand SureCN5093910 family 3 16
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Carbonic anhydrase 14 and Carbonic anhydrase 9 inhibitor 1-(4-... 2 3
Histamine H3 receptor ligand 1-[[4-[4-[(1R)-4-(4-methoxyphenox... 2 1
Free fatty acid receptor 1 ligand 3-[4-[[3-[4-(2-ethylsulfonyl... 5 4
Carbonic anhydrase 7 and Carbonic anhydrase 14 inhibitor 4-(6-... 7 8
Histamine H3 receptor ligand SureCN6071181 family 2 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
5-hydroxytryptamine receptor 7 and Alpha-2C adrenergic recepto... 3 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 13 2
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 2 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Sigma non-opioid intracellular receptor 1 ligand 4-[[1-[(2-bro... 2 0
Substance-P receptor ligand (5S,10S)-5-(4-fluorophenyl)-10-(2-... 3 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Sodium-dependent serotonin transporter inhibitor 4-(4-chloro-2... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Substance-P receptor ligand SureCN6400808 family 2 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
Sodium-dependent serotonin transporter inhibitor AGN-PC-078ZCU... 1 0
Sodium-dependent serotonin transporter inhibitor 3-[(DIMETHYLA... 5 1
Sodium-dependent serotonin transporter inhibitor 1-[5-methoxy-... 1 0
Motilin receptor and Growth hormone secretagogue receptor type... 1 2
Histamine H3 receptor and Histamine H1 receptor ligand AGN-PC-... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 2
Squalene monooxygenase inhibitor 2-[[3-[[[(E)-6,6-dimethylhept... 4 4
Prostaglandin E synthase inhibitor AGN-PC-09QKN6 family 1 3
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Histamine H3 receptor and Histamine H1 receptor ligand (NE)-N-... 1 1
Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... 3 9
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 3
Arachidonate 5-lipoxygenase inhibitor AGN-PC-074BF6 family 1 1
Putative NP ZINC04061066 Family 18 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00173013 DNCL003529 Clinical Trial Drug Dapoxetine
CFAMM00173017 DNC008298 Investigative Drug N,N-dimethyl(2-phenoxyphenyl)methanamine
CFAMM00173027 DNC014046 Investigative Drug N-Benzyl-(6-butoxy-2-naphthyl)-2-aminopropane

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26400 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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