CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD845
Family Name Muscarinic acetylcholine receptor Ligand Umeclidinium Family
No. of Seeds 7 No. of Other Members 50
Family Centroid CFAMM00173063 Functional Category Clinical Trial Drug
Superfamily Biogenic amine receptor ligand Terfenadine Trihexyphenidyl Superfamily
Class Class 89

Cousin Family NamesSeedsMembers
Opioid receptor ligand synthetic opioid methadone analog Dextr... 2 108
Histamine H1 receptor Ligand Terfenadine Family 3 50
Histamine H1 receptor Ligand Diphenhydramine Family 5 75
Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Choline kinase alpha Inhibitor Hemicholinium-3 Family 4 0
Peptide deformylase, mitochondrial Inhibitor Hydroxamates Family 6 17
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13
Substance-P receptor Ligand L-733060 Family 19 71
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Cytochrome P450 2D6 Inhibitor Bs 7840 Family 4 9
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 3 1
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 5 14
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
Sodium-dependent dopamine transporter and Sodium-dependent nor... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 11
Sigma non-opioid intracellular receptor 1 ligand (1R)-1'-benzy... 7 27
Sigma non-opioid intracellular receptor 1 ligand 2-[(3R)-1'-(c... 2 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-076TWX... 8 5
Substance-P receptor ligand (2S)-3-[[3,5-bis(trifluoromethyl)p... 1 4
Substance-P receptor ligand 4-[[3,5-bis(trifluoromethyl)phenyl... 2 1
Substance-P receptor ligand AGN-PC-02K8FR family 1 3
Sodium-dependent dopamine transporter and Sodium-dependent ser... 6 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 6 3
Muscarinic acetylcholine receptor M3 ligand 3-[8-methyl-8-(2-p... 3 0
Substance-P receptor ligand 1-[[(1R,2R,3S)-3-[[3,5-bis(trifluo... 4 3
Sodium-dependent dopamine transporter and Transporter inhibito... 2 0
Substance-P receptor ligand AGN-PC-03NGZP family 3 0
Substance-P receptor ligand (1R,2S,3S)-3-[(1R)-1-[3,5-bis(trif... 8 0
Substance-P receptor ligand SureCN8415737 family 3 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 0
Squalene synthase inhibitor 3-[2-(4-phenylphenyl)ethynyl]-1-az... 2 1
Substance-P receptor ligand AGN-PC-02K8GG family 1 1
Sodium-dependent dopamine transporter and Sigma non-opioid int... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Histamine H1 receptor and 5-hydroxytryptamine receptor 2A liga... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (4aR,... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00173083 CHEMBL489211 Bioactive [1-[2-[(4-methylphenyl)methoxy]ethyl]-1-azoniabicyclo[2.2.2]octan-4-yl]-diphenylmethanol;bromide
CFAMM00173119 CHEMBL491246 Bioactive [1-[2-[(2-methylphenyl)methoxy]ethyl]-1-azoniabicyclo[2.2.2]octan-4-yl]-diphenylmethanol;bromide
CFAMM00173073 CHEMBL476434 Bioactive [1-[2-[(3-methylphenyl)methoxy]ethyl]-1-azoniabicyclo[2.2.2]octan-4-yl]-diphenylmethanol;bromide
CFAMM00173087 CHEMBL523299 Bioactive Umeclidinium bromide
CFAMM00173086 CHEMBL523598 Bioactive AGN-PC-00ALS3
CFAMM00173063 DNCL003608 Clinical Trial Drug Umeclidinium
CFAMM00173095 DNC000104 Investigative Drug 7-tert-butyl-2, 3-dihydro-3, 3-dimethyl substituted dihydrofuran 30 (DHDMBF30)

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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