CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD853
Family Name TS-071 family
No. of Seeds 8 No. of Other Members 36
Family Centroid CFAMM00173169 Functional Category Clinical Trial Drug with Natural Product
Superfamily TS-071 Superfamily
Class Class 1347

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Cannabinoid receptor 1 Ligand Marinol Family 32 454
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Tyrosinase Inhibitor Monobenzone Family 6 197
Oestrogen receptor ligand Dienestrol Family 35 440
Oestrogen receptor Ligand Chlorotrianisene Family 2 102
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Ipriflavone family 62 2480
Rotenone family 16 107
Salicin family 5 629
Sodium/glucose cotransporter 2 Inhibitor Empagliflozin Family 32 52
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
Glucokinase Inhibitor R7201 Family 22 105
Translocator protein Inhibitor Dextofisopam Family 3 250
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Oxi4503 family 4 27
Acolbifene family 10 115
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Glucocorticoid receptor Ligand 1-methoxy-6-phenyl-6h-benzo[c]c... 2 22
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 5 13
Arachidonate 15-lipoxygenase Inhibitor Hydrohalisulfate 1 Family 6 6
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Tubulin beta chain Inhibitor Combretastatin Family 3 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
NAD(P)H dehydrogenase [quinone] 1 Inhibitor NSC-106547 Family 3 65
Arachidonate 15-lipoxygenase and Arachidonate 5-lipoxygenase I... 3 18
Sodium/glucose cotransporter 2 Inhibitor Maackiain Family 1 5
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 4-(1,... 3 31
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Kappa-type opioid receptor Ligand Anisocoumarin H Family 3 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 5 8
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 2 1
Androgen receptor Ligand 2'-hydroxy-3-methoxy-biphenyl-4-carbo... 2 13
Cytochrome P450 3A4 Inhibitor (8r,8'r,9's)-5-methoxyclusin Family 6 20
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Indoleamine 2,3-dioxygenase 1 Inhibitor Naphthalene-1,4-diol F... 2 4
Tyrosine-protein phosphatase non-receptor type 1 and Neuramini... 10 2
Tyrosinase Inhibitor 4-(6-hydroxynaphthalen-2-yl)benzene-1,3-d... 4 2
Tyrosinase Inhibitor Kazinol S Family 1 0
Androgen receptor Ligand Palodesangren E Family 12 43
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19
Sodium/glucose cotransporter 2 inhibitor (2S,3R,4R,5S,6R)-2-[4... 9 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand [(6aR... 1 0
Prelamin-A/C and Solute carrier organic anion transporter fami... 1 15
Estrogen receptor beta and Estrogen receptor ligand 3-fluoro-4... 6 42
Cannabinoid receptor 1 ligand 6,6,9-trimethyl-3-(6-nitrohex-2-... 1 0
Sodium/glucose cotransporter 1 and Sodium/glucose cotransporte... 4 1
Sodium/glucose cotransporter 2 inhibitor (2R,3R,4S,5S,6R)-2-[4... 2 5
Vitamin D3 receptor ligand (3E,5E)-6-[3-[[3,4-bis(hydroxymethy... 2 4
Estrogen receptor beta and Estrogen receptor ligand SureCN4017... 3 5
Sodium/glucose cotransporter 2 inhibitor (2S,3R,4R,5S,6R)-2-[5... 1 1
Vitamin D3 receptor ligand (1R,3S,5Z)-5-[(2E)-2-[(3aS,7aR)-1-[... 1 2
Low affinity sodium-glucose cotransporter and Sodium/glucose c... 1 0
Arachidonate 5-lipoxygenase inhibitor SureCN9727660 family 1 0
Arachidonate 5-lipoxygenase inhibitor SureCN9727677 family 1 2
Arachidonate 5-lipoxygenase inhibitor AGN-PC-073G1D family 1 0
Tyrosine-protein phosphatase non-receptor type 1 and Tyrosine-... 2 1
Arachidonate 5-lipoxygenase inhibitor AGN-PC-00PO2W family 1 1
Androgen receptor ligand AGN-PC-00BPQ5 family 1 3
Acetylcholinesterase inhibitor (2R,3S,4S,5R,6S)-2-(hydroxymeth... 1 1
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 17
Sugar Acids and Derivatives Metabolite 3-Methoxy-4-hydroxyphen... 1 6
Lignans and Norlignans Metabolite cis-Miyabenol C Family 3 0
Phenols and Derivatives Metabolite 2-Ethoxy-4-(4-methyl-1,3-di... 1 0
3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxole NP (3ar,5r,6s,6ar)... 18 6
ahydropyrano[3,2-c]chromene NP ZINC04023039 Family 16 2
2-(4-methoxyphenyl)-10,10-dimethyl-1,3,9-trioxaspiro[5.5]undec... 4 19
Putative NP ZINC00526277 Family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00173184 CHEMBL1093778 Bioactive SureCN7904613
CFAMM00173209 CHEMBL1090058 Bioactive (6S,7R,8R,9S)-6-[3-[(4-methoxyphenyl)methyl]-4-methylphenyl]-2,5-dioxaspiro[3.5]nonane-7,8,9-triol
CFAMM00173183 CHEMBL1093777 Bioactive SureCN10084156
CFAMM00173194 CHEMBL1782368 Bioactive (2S,3R,4R,5S,6R)-2-[3-[(4-ethoxyphenyl)methyl]-4-methylphenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
CFAMM00173189 CHEMBL1092738 Bioactive SureCN12257506
CFAMM00173169 DNCL003772 Clinical Trial Drug TS-071

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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