CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Arachidonate 5-lipoxygenase-activating protein Inhibitor AM103 Family
No. of Seeds 14 No. of Other Members 12
Family Centroid CFAMM00173397 Functional Category Clinical Trial Drug
Superfamily Arachidonate 5-lipoxygenase-activating protein Inhibitor AM103 Superfamily
Class Class 1002

Cousin Family NamesSeedsMembers
Arachidonate 5-lipoxygenase Inhibitor MK-591 Family 9 161
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Arachidonate 5-lipoxygenase-activating protein inhibitor SureC... 5 0
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
Cysteinyl leukotriene receptor 1 ligand 3-[1-[3-[(7-chloroquin... 5 6
Arachidonate 5-lipoxygenase-activating protein inhibitor SureC... 8 1
Cytochrome P450 3A4 and Cytochrome P450 2D6 inhibitor SureCN16... 8 4
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Arachidonate 5-lipoxygenase inhibitor SureCN6008522 family 1 6
Arachidonate 5-lipoxygenase and Arachidonate 15-lipoxygenase i... 1 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 7 1
Arachidonate 5-lipoxygenase-activating protein inhibitor 3-[5-... 1 0
Arachidonate 5-lipoxygenase-activating protein inhibitor AGN-P... 1 0


External ID

Functional Category

Molecule Name

CFAMM00173392 CHEMBL557527 Bioactive AM-103 free acid
CFAMM00173388 CHEMBL1922643 Bioactive 3-[3-tert-butylsulfanyl-5-[(5-ethylpyridin-2-yl)methoxy]-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]indol-2-yl]-2,2-dimethylpropanoic acid
CFAMM00173398 CHEMBL553174 Bioactive SureCN176727
CFAMM00173381 CHEMBL1922653 Bioactive 3-[3-tert-butylsulfanyl-1-[[4-(6-methoxypyridin-2-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acid
CFAMM00173387 CHEMBL1922642 Bioactive 3-[3-tert-butylsulfanyl-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]-5-[(6-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acid
CFAMM00173390 CHEMBL1922645 Bioactive 3-[3-tert-butylsulfanyl-5-[(5,6-dimethylpyridin-2-yl)methoxy]-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]indol-2-yl]-2,2-dimethylpropanoic acid
CFAMM00173396 CHEMBL1922665 Bioactive 3-[3-tert-butylsulfanyl-5-[(5-methylpyridin-2-yl)methoxy]-1-[(4-pyridin-3-ylphenyl)methyl]indol-2-yl]-2,2-dimethylpropanoic acid
CFAMM00173386 CHEMBL1922532 Bioactive 3-[3-tert-butylsulfanyl-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acid
CFAMM00173389 CHEMBL1922644 Bioactive 3-[3-tert-butylsulfanyl-5-[(3,5-dimethylpyridin-2-yl)methoxy]-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]indol-2-yl]-2,2-dimethylpropanoic acid
CFAMM00173385 CHEMBL1922531 Bioactive 3-[3-tert-butylsulfanyl-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]-5-[(4-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acid
CFAMM00173384 CHEMBL1922530 Bioactive 3-[3-tert-butylsulfanyl-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]-5-[(3-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acid
CFAMM00173397 DCL000037 Clinical Trial Drug AM103

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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