CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD864
Family Name Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vidofludimus Family
No. of Seeds 4 No. of Other Members 74
Family Centroid CFAMM00173454 Functional Category Bioactive with Natural Product
Superfamily Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vidofludimus Superfamily
Class Class 704

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
Squalene monooxygenase Inhibitor Tolnaftate Family 1 4
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
D(4) dopamine receptor Ligand PD-165167 Family 2 96
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Receptor tyrosine-protein kinase erbB-2 Inhibitor Mini-antibod... 1 0
Voltage-dependent L-type calcium channel Ligand Sq32,910 Family 1 25
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor 5... 4 24
Mineralocorticoid receptor and Androgen receptor Ligand AL-43 ... 79 235
MO15-related protein kinase Pfmrk Inhibitor 3-[3-(2-hydroxy-et... 1 6
Cytochrome P450 1B1 Inhibitor N-(2,4-dimethoxy-phenyl)-3,5-dim... 1 110
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Oxysterols receptor LXR-alpha Ligand N-{4-[2-(4-methoxyphenyl)... 3 16
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 7 18
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Fatty-acid amide hydrolase 1 Inhibitor 2-fluorophenyl 4-(octyl... 15 9
Fatty-acid amide hydrolase 1 Inhibitor Benzaldehyde O-4-ethoxy... 21 4
Fatty-acid amide hydrolase 1 Inhibitor Phenylcarbamic Acid Bip... 3 7
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Aromatase Inhibitor 2,3,4-trimethoxy-4'-amino-trans-stilbene F... 9 14
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Progesterone receptor ligand SureCN3874009 family 2 7
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 11 26
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 6 11
Transient receptor potential cation channel subfamily V member... 1 0
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 6 2
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 4 2
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 3 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 1
Androgen receptor ligand tert-butyl 4-methyl-2,5-dioxo-1H-chro... 3 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-(3-methoxy-2-me... 2 4
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
Histamine H3 receptor ligand SureCN3057839 family 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Cannabinoid receptor 1 ligand 6-[(6aR,10aR)-1-hydroxy-6,6,9-tr... 2 1
Protein-S-isoprenylcysteine O-methyltransferase inhibitor N-[2... 1 2
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 1 1
Melanocortin receptor 4 ligand [4-[2-[(1S)-1-amino-3-methylbut... 1 0
Adenosine receptor A3 ligand N-(4-methoxyphenyl)-2-oxo-1H-quin... 1 2
Dihydroorotate dehydrogenase (quinone), mitochondrial and Dihy... 1 0
Major prion protein and Microtubule-associated protein tau inh... 2 10
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 1
Beta-lactamase and Microtubule-associated protein tau inhibito... 1 1
N-(4-acetamidophenyl)-2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)... 1 0
4-(4-methoxyphenyl)-2,4,5,10-tetrahydro-1H-pyrrolo[3,4-c][1,5]... 4 0
Putative NP ZINC04043041 Family 4 1
NP (e)-4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)vinyl)-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00173408 CHEMBL154623 Bioactive 2-[[2,3,5,6-tetrafluoro-4-[3-(trifluoromethoxy)phenyl]phenyl]carbamoyl]cyclopentene-1-carboxylic acid
CFAMM00173415 CHEMBL345701 Bioactive 2-[[2,3,5,6-tetrafluoro-4-(2-methoxyphenyl)phenyl]carbamoyl]cyclopentene-1-carboxylic acid
CFAMM00173479 CHEMBL7867 Bioactive SureCN8154042
CFAMM00173490 CHEMBL194955 Bioactive 4-[[2,3,5,6-tetrafluoro-4-[3-(trifluoromethoxy)phenyl]phenyl]carbamoyl]-2,5-dihydrothiophene-3-carboxylic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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