CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD89
Family Name Poly [ADP-ribose] polymerase 1 Inhibitor KU-0059436 Family
No. of Seeds 21 No. of Other Members 45
Family Centroid CFAMM00133523 Functional Category Clinical Trial Drug
Superfamily Poly [ADP-ribose] polymerase 1 Inhibitor KU-0059436 Superfamily
Class Class 884

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Azelastine Family 14 29
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Poly [ADP-ribose] polymerase 1 Inhibitor 4-benzylphthalazin-1(... 2 5
Poly [ADP-ribose] polymerase 1 Inhibitor KU-58684 Family 6 40
Poly [ADP-ribose] polymerase 1 Inhibitor 4-(5-morpholin-4-yl-p... 2 0
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 7 9
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
Substance-K receptor ligand 4-(4-methylphenyl)-N-[1-[[(2S)-5-[... 6 0
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-(4-cy... 1 0
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 3
Histamine H3 receptor ligand 2-methyl-6-[4-[(2S)-2-(pyrrolidin... 1 1
B1 bradykinin receptor ligand 4-(4-methyl-1-oxophthalazin-2-yl... 5 27
Histamine H3 receptor ligand 2-methyl-6-[4-[2-[(2R)-2-methylpy... 2 4
Melanin-concentrating hormone receptor 1 ligand N-[3-[1-[3-[4-... 4 13
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Poly [ADP-ribose] polymerase 1 inhibitor 2-fluoro-N-[2-(4-meth... 11 0
Poly [ADP-ribose] polymerase 1 inhibitor 8-[[4-fluoro-3-(4-phe... 2 0
Melanocortin receptor 4 and Melanocortin receptor 3 ligand (2S... 2 0
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor Acylpiperazine analog... 2 0
Muscarinic acetylcholine receptor M3 ligand N-[[4-fluoro-3-[3-... 3 0
Cathepsin S and Cathepsin L1 inhibitor (Z,3S)-1-diazonio-3-[[2... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor 3-[[4-fluoro-3-[4-(2-... 15 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00133534 CHEMBL599802 Bioactive 3-[[4-fluoro-3-[4-[2-methyl-2-(methylamino)propanoyl]piperazine-1-carbonyl]phenyl]methyl]-4,5-dimethyl-1H-pyridazin-6-one
CFAMM00133487 CHEMBL2323218 Bioactive CHEMBL2323218
CFAMM00133494 CHEMBL493045 Bioactive Piperazine analogue, 24
CFAMM00133504 CHEMBL494505 Bioactive Acylpiperazine analogue, 46
CFAMM00133492 CHEMBL523887 Bioactive Homopiperazine analogue, 16
CFAMM00133484 CHEMBL493306 Bioactive Piperazine analogue, 36
CFAMM00133503 CHEMBL481881 Bioactive phthalazinone, 3
CFAMM00133568 CHEMBL492692 Bioactive Alkylpiperazine analogue, 41
CFAMM00133491 CHEMBL493693 Bioactive Alkylpiperazine analogue, 43
CFAMM00133510 CHEMBL2058920 Bioactive 8-[[3-(4-benzoylpiperazine-1-carbonyl)-4-fluorophenyl]methyl]-2,3,4,6-tetrahydro-1H-pyrido[2,3-d]pyridazin-5-one
CFAMM00133531 CHEMBL599803 Bioactive 3-[[4-fluoro-3-[4-[1-(methylamino)cyclopropanecarbonyl]piperazine-1-carbonyl]phenyl]methyl]-4,5-dimethyl-1H-pyridazin-6-one
CFAMM00133483 CHEMBL524190 Bioactive Acylpiperazine analogue, 48
CFAMM00133521 CHEMBL503239 Bioactive Alkylpiperazine analogue, 44
CFAMM00133490 CHEMBL493692 Bioactive Alkylpiperazine analogue, 42
CFAMM00133528 CHEMBL201616 Bioactive Piperazine analogue, 23
CFAMM00133500 CHEMBL494874 Bioactive Homopiperazine analogue, 20
CFAMM00133537 CHEMBL2058913 Bioactive 8-[[4-fluoro-3-[(2R)-2-phenylpiperazine-1-carbonyl]phenyl]methyl]-2,3,4,6-tetrahydro-1H-pyrido[2,3-d]pyridazin-5-one
CFAMM00133544 CHEMBL495322 Bioactive Acylpiperazine analogue, 45
CFAMM00133488 CHEMBL2322618 Bioactive CHEMBL2322618
CFAMM00133523 DCL000145 Clinical Trial Drug KU-0059436
CFAMM00133507 DNC006237 Investigative Drug KU-0058948

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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