CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD9
Family Name Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family
No. of Seeds 16 No. of Other Members 135
Family Centroid CFAMM00127063 Functional Category Clinical Trial Drug
Superfamily Aurora kinase B and Aurora kinase A Inhibitor CYC116 Superfamily
Class Class 817

Cousin Family NamesSeedsMembers
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 5 60
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 11
Serine/threonine-protein kinase B-raf Inhibitor GSK2118436 Family 5 19
GDC-0349 family 44 77
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing... 3 16
Cyclin-dependent kinase 2 Inhibitor 4-(2,4-dimethyl-thiazol-5-... 2 14
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
TGF-beta receptor type-1 Ligand 4-pyridin-2-yl-5-quinolin-4-yl... 4 23
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 3 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethy... 2 2
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Histamine H3 receptor Ligand 2-(1,4'-bipiperidin-1'-yl)thiazol... 2 23
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-264... 6 32
D(2) dopamine receptor Ligand PD-135146 Family 5 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Deoxycytidine kinase inhibitor AGN-PC-07Z9B3 family 2 7
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 2 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 6
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 1 inhibi... 2 0
Vascular endothelial growth factor receptor 2 and Mast/stem ce... 10 27
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 6 11
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M88D fa... 2 1
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 8
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Amine oxidase [flavin-containing] B inhibitor 4-(4-fluoropheny... 3 4
Platelet-activating factor receptor ligand Foropafant family 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Neuropeptide Y receptor type 5 ligand N-[5-[(4-thiophen-3-yl-1... 1 4
Neuropeptide Y receptor type 5 ligand 2-fluoro-N-[5-[(4-pyridi... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 1
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 3
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 inhibitor 3-[5-[2-[(4-mor... 2 3
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Ketohexokinase inhibitor 4-N-(2-methylsulfanylphenyl)-2-pipera... 6 23
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
Cyclin-dependent kinase 6 and Cyclin-dependent kinase 4 inhibi... 1 0
Cholinesterase and Acetylcholinesterase inhibitor 3-[ethyl-[3-... 6 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 0
Metabotropic glutamate receptor 5 ligand 2-methyl-N-(6-methylp... 1 8
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 0
Vascular endothelial growth factor receptor 2 ligand AC1NS6KN ... 4 5
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
G1/S-specific cyclin-E1 and G1/S-specific cyclin-E2 inhibitor ... 5 1
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor CDK Inhibito... 8 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor 2-(4-hydroxy... 2 15
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 5-[5-chloro-... 2 18
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 7 7
Methionine aminopeptidase 2 inhibitor SureCN5376630 family 1 0
Tyrosine-protein kinase ITK/TSK and Tyrosine-protein kinase Lc... 2 6
Aurora kinase B and Tyrosine-protein kinase ITK/TSK inhibitor ... 2 2
Tyrosine-protein kinase ITK/TSK and Tyrosine-protein kinase Lc... 5 0
Tyrosine-protein kinase ITK/TSK and Tyrosine-protein kinase Lc... 2 2
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Mitogen-activated protein kinase 14 inhibitor 303163-37-3 family 1 2
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Transient receptor potential cation channel subfamily V member... 9 13
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Transient receptor potential cation channel subfamily V member... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck ligand... 1 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 1 0
Adenosine receptor A1 ligand AGN-PC-075Q3Q family 1 1
Vascular endothelial growth factor receptor 2 and Insulin rece... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 1
Epidermal growth factor receptor ligand AGN-PC-00RWKI family 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00127111 CHEMBL1084969 Bioactive AGN-PC-07YGUE
CFAMM00127072 CHEMBL46817 Bioactive N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N',N'-DIMETHYL-BENZENE-1,4-DIAMINE
CFAMM00127109 CHEMBL1087398 Bioactive 2-[[2-[[(1S)-1-(5-fluoropyridin-2-yl)ethyl]amino]-6-morpholin-4-ylpyrimidin-4-yl]amino]-1,3-thiazole-5-carbonitrile
CFAMM00126972 CHEMBL2312186 Bioactive 4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]-2-(4-morpholin-4-ylsulfonylanilino)pyrimidine-5-carbonitrile
CFAMM00127102 CHEMBL1083786 Bioactive SureCN2073428
CFAMM00126958 CHEMBL1085626 Bioactive SureCN2073867
CFAMM00126951 CHEMBL2348646 Bioactive 1-[4-[3-[[5-fluoro-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]phenyl]piperazin-1-yl]ethanone
CFAMM00126990 CHEMBL1083484 Bioactive AGN-PC-00F9YB
CFAMM00127075 CHEMBL1087269 Bioactive 2-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-4-N-(5-methyl-1,3-thiazol-2-yl)-6-morpholin-4-ylpyrimidine-2,4-diamine
CFAMM00127100 CHEMBL1083785 Bioactive Kinome_756
CFAMM00126950 CHEMBL2348647 Bioactive 5-[5-fluoro-2-(3-piperazin-1-ylanilino)pyrimidin-4-yl]-N,4-dimethyl-1,3-thiazol-2-amine
CFAMM00126956 CHEMBL2348648 Bioactive 5-[5-fluoro-2-(3-morpholin-4-ylanilino)pyrimidin-4-yl]-N,4-dimethyl-1,3-thiazol-2-amine
CFAMM00126997 CHEMBL1084630 Bioactive N-ethyl-4-methyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine
CFAMM00126962 CHEMBL1084629 Bioactive N,4-dimethyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine
CFAMM00126975 CHEMBL424696 Bioactive AGN-PC-0763ED
CFAMM00127063 DCL000010 Clinical Trial Drug CYC116

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21794 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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