CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD96
Family Name Farnesyltransferase beta subunit, putative Inhibitor Lonafarnib Family
No. of Seeds 36 No. of Other Members 87
Family Centroid CFAMM00133761 Functional Category Clinical Trial Drug
Superfamily Farnesyltransferase beta subunit, putative Inhibitor Lonafarnib Superfamily
Class Class 891

Cousin Family NamesSeedsMembers
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Histamine H1 receptor Ligand Pheniramine Family 10 380
Transient receptor potential cation channel subfamily V member... 16 295
ABC294640 family 5 75
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Prothrombin inhibitor SureCN7371121 family 13 3
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 3
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 10 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 1
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Coagulation factor X and Prothrombin inhibitor SureCN8243313 f... 10 8
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 17
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 2
Reverse transcriptase/RNaseH inhibitor (4s)-6-chloro-4-cyclopr... 5 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00133718 CHEMBL356519 Bioactive 1-[4-[(11S)-3,7-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-(1-oxidopyridin-1-ium-4-yl)ethanone
CFAMM00133792 CHEMBL66462 Bioactive 1-[4-(3,10-dibromo-8-chloro-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-11-ylidene)piperidin-1-yl]-2-(1-oxidopyridin-1-ium-4-yl)ethanone
CFAMM00133759 CHEMBL364342 Bioactive 4-[2-[4-[(11S)-3,10-dibromo-8-chloro-11H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-oxoethyl]piperidine-1-carboxamide
CFAMM00133785 CHEMBL443022 Bioactive 1-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-[1-[2-(1,2,4-triazol-1-yl)acetyl]piperidin-4-yl]ethanone
CFAMM00133687 CHEMBL327548 Bioactive 1-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-[1-(1-oxidopyridin-1-ium-4-carbonyl)piperidin-4-yl]ethanone
CFAMM00133698 CHEMBL358796 Bioactive SureCN3314457
CFAMM00133724 CHEMBL92499 Bioactive 2-[4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-oxoethyl]piperidin-1-yl]acetamide
CFAMM00133717 CHEMBL186303 Bioactive 1-[4-[(11S)-3,10-dibromo-8-chloro-11H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-(1-oxidopyridin-1-ium-4-yl)ethanone
CFAMM00133784 CHEMBL90435 Bioactive SureCN14372733
CFAMM00133797 CHEMBL432573 Bioactive SureCN14372946
CFAMM00133777 CHEMBL333864 Bioactive 1-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-(1-oxidopyridin-1-ium-4-yl)ethanone
CFAMM00133709 CHEMBL89304 Bioactive 2-[4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-oxoethyl]piperidin-1-yl]-2-oxoacetamide
CFAMM00133783 CHEMBL342099 Bioactive 4-[2-[4-[(11S)-3,7-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperazin-1-yl]-2-oxoethyl]piperidine-1-carboxamide
CFAMM00133807 CHEMBL357148 Bioactive 1-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperazin-1-yl]-2-(1-oxidopyridin-1-ium-4-yl)ethanone
CFAMM00133722 CHEMBL440732 Bioactive 4-[[[[4-(3-bromo-8-chloro-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-11-ylidene)piperidin-1-yl]-(cyanoamino)methylidene]amino]methyl]piperidine-1-carboxamide
CFAMM00133692 CHEMBL314996 Bioactive (2S)-2-amino-1-[4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-oxoethyl]piperidin-1-yl]propan-1-one
CFAMM00133708 CHEMBL88713 Bioactive SureCN13351987
CFAMM00133769 CHEMBL344068 Bioactive 1-[4-[(11S)-3,7-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperazin-1-yl]-2-(1-oxidopyridin-1-ium-4-yl)ethanone
CFAMM00133748 CHEMBL328713 Bioactive 1-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-[1-(2-morpholin-4-yl-2-oxoethyl)piperidin-4-yl]ethanone
CFAMM00133762 CHEMBL91213 Bioactive 1-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-[1-(2-pyrrol-1-ylacetyl)piperidin-4-yl]ethanone
CFAMM00133775 CHEMBL370411 Bioactive AGN-PC-075Z5Q
CFAMM00133727 CHEMBL88432 Bioactive 2-[1-(2-aminoacetyl)piperidin-4-yl]-1-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]ethanone
CFAMM00133768 CHEMBL90962 Bioactive 2-[4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-oxoethyl]piperidin-1-yl]-N,N-diethylacetamide
CFAMM00133805 CHEMBL90234 Bioactive (2R)-2-amino-1-[4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-oxoethyl]piperidin-1-yl]propan-1-one
CFAMM00133774 CHEMBL315915 Bioactive 5-[4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-oxoethyl]piperidine-1-carbonyl]pyridine-3-carboxamide
CFAMM00133800 CHEMBL69954 Bioactive 4-[2-[4-[(11S)-3,7-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-oxoethyl]piperidine-1-carboxamide
CFAMM00133740 CHEMBL11001 Bioactive SureCN8878358
CFAMM00133754 CHEMBL423680 Bioactive 1-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-(1-methylsulfonylpiperidin-4-yl)ethanone
CFAMM00133706 CHEMBL327204 Bioactive SureCN14370715
CFAMM00133746 CHEMBL430830 Bioactive 3-[4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-oxoethyl]piperidin-1-yl]-3-oxopropanenitrile
CFAMM00133804 CHEMBL313635 Bioactive 4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-oxoethyl]-N,N-dimethylpiperidine-1-sulfonamide
CFAMM00133712 CHEMBL155363 Bioactive 1-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-(1-oxidopyridin-1-ium-3-yl)ethanone
CFAMM00133725 CHEMBL264305 Bioactive 4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-oxoethyl]piperidine-1-sulfonamide
CFAMM00133739 CHEMBL314317 Bioactive 1-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-[1-(1-oxidopyridin-1-ium-3-carbonyl)piperidin-4-yl]ethanone
CFAMM00133766 CHEMBL90050 Bioactive 2-[4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-oxoethyl]piperidin-1-yl]-N,N-dimethyl-2-oxoacetamide
CFAMM00133761 DCL000152 Clinical Trial Drug Lonafarnib

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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