CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Benzoxepines Metabolite 4,5-Dihydro-1-benzoxepin-3(2H)-one Family
No. of Seeds 1 No. of Other Members 2
Family Centroid CFAMM00536078 Functional Category Human Metabolite
Superfamily Cathepsin S Inhibitor 2-[(2',3',4'-trifluorobiphenyl-2-yl)oxy]ethanol Superfamily
Class Class 614

Cousin Family NamesSeedsMembers
Lipoprotein lipase Inhibitor Gemfibrozil Family 1 28
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 1,1,... 2 8
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Interleukin-8 Inhibitor 2-(2-(2-fluorophenoxy)phenyl)acetic Ac... 2 4
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
Amine oxidase [flavin-containing] B inhibitor 5-(4,4,4-trifluo... 2 9
Trace amine-associated receptor 1 ligand SureCN13886619 family 1 1
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 8
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 1 1
Putative NP ZINC04043753 Family 8 6
benzofuran-2-one NP 5-hydroxybenzofuran-2(3h)-one Family 1 0
2-(2-methoxyphenyl)-5-oxooxolane-3-carboxylate NP ZINC00132596... 4 2
5-(4-methoxyphenyl)-2,2-dimethyloxolan-3-one NP 5-(4-methoxyph... 2 0


External ID

Functional Category

Molecule Name

CFAMM00536078 HMDB29714 Human Metabolite 4,5-Dihydro-1-benzoxepin-3(2H)-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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