CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1001
Family Name Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylphenoxy)methyl]pyridine Family
No. of Seeds 5 No. of Other Members 48
Family Centroid CFAMM00224558 Functional Category Investigative Drug with Natural Product
Superfamily Hemoglobin subunit alpha and Enoyl-[acyl-carrier-protein] reductase [NADH] Binder Superfamily
Class Class 284

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Histamine H1 receptor Ligand Doxylamine Family 2 91
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Mepyramine Family 5 65
Na+-K+-ATPase transmembrane protein Inhibitor Sanguinarine Family 8 20
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Citric Acid family 2 58
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Melanin-concentrating hormone receptor 1 Ligand NGD-4715 Family 1 1
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 67 130
Histamine H3 receptor Ligand GSK239512 Family 2 65
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
Sodium-dependent noradrenaline transporter Inhibitor Neri Iv F... 6 58
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Tivozanib family 4 6
SB1518 family 7 103
Apricoxib family 8 77
PF-02545920 family 16 140
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 5 23
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 6 8
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 5
D(2) dopamine receptor Ligand SLV-314 Family 19 69
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 1
Oestrogen receptor and Estrogen receptor beta Ligand Estrogen ... 7 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methox... 3 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Squalene synthase Inhibitor ER-119884 Family 2 3
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 2 3
MO15-related protein kinase Pfmrk Inhibitor WR-289010 Family 2 506
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3,3'-pyrazine-2,5-... 2 14
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 3 24
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(4-f... 2 5
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
5-hydroxytryptamine receptor 1A Ligand CP-293019 Family 9 24
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Acetylcholinesterase and Cholinesterase Inhibitor 1,4-di(berbe... 5 0
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Endothelin-1 receptor and Endothelin B receptor ligand (5S,6R,... 15 28
Progesterone receptor and Glucocorticoid receptor ligand (5Z)-... 5 2
Dual specificity mitogen-activated protein kinase kinase 1 inh... 5 7
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
Endothelin-1 receptor and Endothelin B receptor ligand 3-(1,3-... 1 1
Histamine H1 receptor and Potassium voltage-gated channel subf... 3 1
Endothelin-1 receptor and Endothelin B receptor ligand SureCN1... 3 16
Leukotriene B4 receptor 1 ligand AGN-PC-04XM3V family 3 10
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 5 45
Neuronal acetylcholine receptor subunit alpha-3 and Neuronal a... 2 0
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 6 4
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 17
Ferritin light chain and Ras-related protein Rab-9A inhibitor ... 1 11
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 1
Leukotriene B4 receptor 1 ligand SureCN8987047 family 4 3
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 7 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
Endothelin-1 receptor ligand SureCN8118632 family 4 5
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 1
Platelet-derived growth factor receptor beta ligand AGN-PC-075... 3 0
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 0
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 6 1
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
Translocator protein inhibitor N-methyl-2-(2-oxo-5-pyridin-4-y... 8 15
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Beta-secretase 1 inhibitor N-[(2S,3R)-1-(1,3-benzodioxol-5-yl)... 3 5
Histamine H3 receptor and D(3) dopamine receptor ligand BODILI... 1 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 6 4
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 11 7
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Hepatocyte growth factor receptor ligand 1-[(E)-(2,4-difluorop... 2 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Transient receptor potential cation channel subfamily V member... 6 1
Steroid hormone receptor ERR1 and Steroid hormone receptor ERR... 1 4
Corticotropin-releasing factor receptor 1 ligand 3-ethyl-1-(2-... 5 15
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 8
Serine/threonine-protein kinase Chk1 inhibitor SureCN4854955 f... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Vascular endothelial growth factor receptor 2 and Tyrosine-pro... 4 0
Renin inhibitor SureCN6042213 family 2 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor N-[4... 1 0
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
5-hydroxytryptamine receptor 6 ligand AGN-PC-075BWR family 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor AGN-... 1 3
Vascular endothelial growth factor receptor 2 and Platelet-der... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PJ... 4 4
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Glucocorticoid receptor ligand SureCN3894124 family 3 0
72 kDa type IV collagenase and Aminopeptidase N inhibitor ly52... 1 0
Sodium-dependent serotonin transporter inhibitor SureCN5878703... 4 5
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 1 0
Adenosine receptor A1 ligand BAS 00727702 family 1 4
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
Renin inhibitor SureCN7300793 family 2 5
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 2
Sodium-dependent serotonin transporter and Alpha-2C adrenergic... 2 2
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
Ectonucleotide pyrophosphatase/phosphodiesterase family member... 1 0
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 2 10
Glutamate receptor ionotropic, NMDA 2B and Cytochrome P450 2D6... 2 3
Transient receptor potential cation channel subfamily V member... 3 2
Farnesyl pyrophosphate synthase inhibitor [phosphono-[[4-(4-pr... 6 0
Small conductance calcium-activated potassium channel protein ... 2 2
Carbonic anhydrase 12 and Carbonic anhydrase 9 inhibitor 4-[4-... 1 0
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 1 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
5-hydroxytryptamine receptor 1A ligand (1S,5R)-8-[[(3S)-5-meth... 2 0
Coagulation factor X and Cationic trypsin inhibitor 1qb6 family 4 15
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 2
Orexin receptor type 1 and Orexin receptor type 2 ligand SureC... 1 3
Cytochrome P450 2D6 inhibitor AGN-PC-0509UI family 1 2
Mitogen-activated protein kinase 14 inhibitor Aminopyridine N-... 3 1
Beta-secretase 1 and Beta-secretase 2 inhibitor AGN-PC-076LAV ... 1 3
Muscleblind-like protein 1 and Lysosomal alpha-glucosidase inh... 2 0
M-phase inducer phosphatase 2 and Dual specificity protein pho... 1 0
Beta-lactamase and Muscleblind-like protein 1 inhibitor 2,3-Bi... 1 2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]... 1 0
Acetylcholinesterase and Cholinesterase inhibitor CHEMBL191520... 2 0
Protein kinase C theta type inhibitor AGN-PC-04SQV8 family 1 0
Platelet-activating factor receptor ligand AGN-PC-001U4L family 2 0
3-(4-methoxyphenyl)-1-pyrrol-1-ylpropan-1-one NP Agn-pc-08zsfd... 1 1
(4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0
ylethanone NP (z)-2-(7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoli... 3 3
NP (2r,3r,4s,5r)-2-(acetoxymethyl)-6-(quinolin-8-yloxy)tetrahy... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00224594 CHEMBL36007 Bioactive SureCN1387472
CFAMM00224565 CHEMBL284386 Bioactive AGN-PC-073JV8
CFAMM00224612 CHEMBL286603 Bioactive 4-[(2R)-2-(3-cyclopentyloxy-4-methoxyphenyl)-2-phenylethyl]-1-oxidopyridin-1-ium
CFAMM00224558 DNC003333 Investigative Drug 2-[(2-methoxy-5-methylphenoxy)methyl]pyridine
CFAMM00224591 DNC003814 Investigative Drug RG-13022

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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