CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1002
Family Name Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylphenoxy)methyl]pyridine Family
No. of Seeds 3 No. of Other Members 12
Family Centroid CFAMM00224630 Functional Category Investigative Drug
Superfamily Reverse transcriptase and Hemoglobin subunit alpha Binder Superfamily
Class Class 1002

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Pyridostigmine Family 5 197
Histamine H1 receptor Ligand Doxylamine Family 2 91
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Mepyramine Family 5 65
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Apricoxib family 8 77
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
Acetyl-CoA carboxylase 1 Inhibitor Clodinafop Family 2 17
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methox... 3 9
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
MO15-related protein kinase Pfmrk Inhibitor WR-289010 Family 2 506
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Oxytocin receptor and Vasopressin V1a receptor Ligand L-372662... 31 23
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
Somatostatin receptor type 5 ligand AGN-PC-088VSK family 2 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Acetylcholinesterase and Butyrylcholinesterase inhibitor [3-[[... 3 68
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Endothelin-1 receptor ligand SureCN8118632 family 4 5
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
Histamine H3 receptor and D(3) dopamine receptor ligand BODILI... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Sodium-dependent serotonin transporter inhibitor SureCN5878703... 4 5
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
Testosterone 17-beta-dehydrogenase 3 inhibitor AGN-PC-04XS1Y f... 1 4
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
Aromatase inhibitor isoflavone deriv. 5m family 1 0
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
Farnesyl pyrophosphate synthase inhibitor [phosphono-[[4-(4-pr... 6 0
Corticotropin-releasing factor receptor 1 ligand 2-[2,6-dimeth... 10 10
Small conductance calcium-activated potassium channel protein ... 2 2
Hormone-sensitive lipase inhibitor AGN-PC-046LTD family 3 8
5-hydroxytryptamine receptor 1A ligand (1S,5R)-8-[[(3S)-5-meth... 2 0
Cytochrome P450 2D6 inhibitor AGN-PC-0509UI family 1 2
Ras-related protein Rab-9A and Niemann-Pick C1 protein inhibit... 1 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 1
Acetylcholinesterase inhibitor 7-[5-(3,5-difluoro-4-methoxypyr... 1 0
(4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00224624 DNC006856 Investigative Drug 2-(3-(3-methoxyphenoxy)prop-1-ynyl)pyridine
CFAMM00224630 DNC003334 Investigative Drug 4-[(5-methoxy-2-methylphenoxy)methyl]pyridine
CFAMM00224632 DNC004393 Investigative Drug 4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-pyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27047 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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