CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1005
Family Name Peroxisome proliferator-activated receptor gamma Ligand (2s)-2-(4-ethylphenoxy)-3-phenylpropanoic Acid Family
No. of Seeds 10 No. of Other Members 126
Family Centroid CFAMM00224767 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Peroxisome proliferator-activated receptor gamma Ligand (2s)-2-(4-ethylphenoxy)-3-phenylpropanoic Acid Superfamily
Class Class 614

Cousin Family NamesSeedsMembers
Thyroid hormone receptor alpha ligand thyroid hormone analog L... 10 61
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Lipoprotein lipase Inhibitor Gemfibrozil Family 1 28
Lipoprotein lipase Inhibitor Clofibrate Family 3 28
Peroxisome proliferator-activated receptor alpha Ligand Fenofi... 3 127
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Solute carrier family 12 member 1 Inhibitor Ethacrynic Acid Fa... 3 42
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
Tyrosinase Inhibitor Monobenzone Family 6 197
Oestrogen receptor ligand Dienestrol Family 35 440
Oestrogen receptor Ligand Chlorotrianisene Family 2 102
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
Sodium channel Ligand Permethrin Family 1 25
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
Peroxisome proliferator-activated receptor alpha Ligand Ciprof... 1 5
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Ipriflavone family 62 2480
taste receptor Ligand Cynarin Family 6 124
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Translocator protein Inhibitor Dextofisopam Family 3 250
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Free fatty acid receptor 1 Ligand TAK-875 Family 2 54
TS-071 family 8 36
Eprotirome family 11 50
Arachidonate 5-lipoxygenase Inhibitor Caffeic Acid Family 3 32
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Integrase Inhibitor L-708,906 Family 1 8
Endothelin-1 receptor Ligand PD156707 Family 41 211
Prostaglandin G/H synthase 1 Inhibitor (3-chloro-4-propoxy-phe... 2 10
Macrophage migration inhibitory factor and Prothrombin Inhibit... 2 49
Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5... 5 82
Proto-oncogene tyrosine-protein kinase Src Inhibitor Malonic A... 1 34
Cathepsin S Inhibitor 2-[(2',3',4'-trifluorobiphenyl-2-yl)oxy]... 2 16
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 2 14
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Steryl-sulfatase Inhibitor 4-sulfamoyloxy-benzoic Acid Hexyl E... 11 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Ligand... 4 26
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
Prostacyclin receptor Ligand AP-227 Family 1 7
Steryl-sulfatase Inhibitor Sulfamic Acid 2-nonyl-4-oxo-4h-chro... 4 68
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 7-(b... 4 42
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 1,1,... 2 8
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
Thyroid hormone receptor beta Ligand (3,5-dibromo-4-pentyloxy-... 5 21
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 5 13
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 127
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
Prostaglandin D2 receptor 2 Ligand 2-(4-bromo-2-tert-butylphen... 3 4
NAD(P)H dehydrogenase [quinone] 1 Inhibitor NSC-106547 Family 3 65
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 4-(1,... 3 31
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Prostaglandin D2 receptor 2 Ligand 2-(4-chloro-2-cyclohexylphe... 7 25
Prostaglandin D2 receptor 2 Ligand 2-(4-cyano-2-cyclohexylphen... 6 3
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 12
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Matrix metalloproteinase-9 and Collagenase 3 Inhibitor 4-amino... 1 8
Cytochrome P450 3A4 Inhibitor Hinokinin Family 2 10
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Interleukin-8 Inhibitor 2-(2-(2-fluorophenoxy)phenyl)acetic Ac... 2 4
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
Aromatase Inhibitor NSC-122427 Family 1 0
NAD(P)H dehydrogenase [quinone] 1 Inhibitor Ethyl Bis(4-hydrox... 5 7
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Neutrophil elastase Inhibitor E-6-o-p-methoxycinnamoyl Scandos... 2 68
Tyrosine-protein phosphatase non-receptor type 1 and Neuramini... 10 2
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Amine oxidase [flavin-containing] B Inhibitor 8-bromo-6-methyl... 5 44
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Prostaglandin G/H synthase 1 Inhibitor 2-(2-methoxyphenyl)-1h-... 1 11
Acetylcholinesterase Inhibitor 4-formylphenyl-o-beta-d-ribopyr... 2 17
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
72 kDa type IV collagenase Inhibitor Lithospermic Acid Family 1 0
Creatine kinase Inhibitor 5-(4'-benzoylbiphenyl-4-yl)-2-furoic... 2 66
Hormone-sensitive lipase Inhibitor 2-(3-methoxybenzylthio)-2-p... 1 19
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 6 6
Peroxisome proliferator-activated receptor alpha and Peroxisom... 4 28
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 7
Retinoic acid receptor RXR-alpha and Peroxisome proliferator-a... 3 17
Prelamin-A/C and Solute carrier organic anion transporter fami... 1 15
Peroxisome proliferator-activated receptor alpha and Peroxisom... 7 6
Endothelin-1 receptor ligand (2S)-2-(1,3-benzodioxol-5-yl)-4-m... 17 0
Prostaglandin D2 receptor 2 and Chemoattractant receptor-homol... 4 37
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 3
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 7
Free fatty acid receptor 1 ligand 3-[4-[[3-[2,6-dimethyl-4-[3-... 1 0
Free fatty acid receptor 1 ligand 3-[4-[[3-[4-(1,1-dioxothian-... 3 0
Arachidonate 5-lipoxygenase inhibitor methyl (2S)-2-[3-fluoro-... 2 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 4 2
Peroxisome proliferator-activated receptor delta ligand SureCN... 1 0
Protein kinase C alpha type inhibitor [2-(hydroxymethyl)-5-oxo... 2 4
Kinesin-like protein KIF11 inhibitor 2-amino-5-(4-methoxypheny... 1 4
Estrogen receptor beta and Estrogen receptor ligand SureCN4017... 3 5
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 7
Androgen receptor and Estrogen receptor ligand estradiol benzo... 1 29
Cysteinyl leukotriene receptor 1 ligand 4-[(E)-1-carboxy-6-[4-... 2 9
Vitamin D3 receptor ligand (1R,3S,5Z)-5-[(2E)-2-[(3aS,7aR)-1-[... 1 2
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R)... 1 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Tyrosine-protein phosphatase non-receptor type 1 ligand (2S)-2... 9 3
Amine oxidase [flavin-containing] B inhibitor 4-[4-[(3-chlorop... 2 3
Prostaglandin D2 receptor 2 ligand 2-[2-[2-(2-chlorophenyl)eth... 1 0
Free fatty acid receptor 1 ligand 3-[4-[2-[2-(cyanomethoxy)phe... 1 2
Free fatty acid receptor 1 ligand 3-[4-[2-[3-(trifluoromethoxy... 1 0
Neutrophil elastase and Prothrombin inhibitor CHEMBL265335 family 2 4
Cytosolic phospholipase A2 beta inhibitor 5-[3-(4-decoxyphenox... 2 15
Cytosolic phospholipase A2 beta inhibitor 2-[3-[3-(4-decoxyphe... 1 0
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 1 1
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 8
Thioredoxin glutathione reductase and Beta-lactamase inhibitor... 1 0
M-phase inducer phosphatase 2 and Dual specificity protein pho... 1 0
G2/mitotic-specific cyclin-B1 and Cyclin-dependent kinase 1 in... 2 8
Steryl-sulfatase inhibitor [(8R,9S,13S,14S)-13-methyl-17-oxo-7... 1 9
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 4
Beta-lactamase inhibitor AGN-PC-0A9UJZ family 1 3
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor propan... 3 5
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 8
NS5B protein inhibitor SureCN3988565 family 2 4
Glutamate carboxypeptidase 2 inhibitor 2-phenylmethoxy-6-(2-su... 2 3
D-amino-acid oxidase inhibitor 5-hydroxy-2-(naphthalen-1-yloxy... 2 0
Integrase inhibitor AC1NX3RZ family 1 0
Sugar Acids and Derivatives Metabolite 3-Methoxy-4-hydroxyphen... 1 6
Benzoxepines Metabolite 4,5-Dihydro-1-benzoxepin-3(2H)-one Family 1 2
Benzyl Alcohols and Derivatives Metabolite (2R,3S)-Piscidic ac... 1 1
Benzoic Acid and Derivatives Metabolite Methyl 3-(2,3-dihydrox... 1 3
Benzyloxycarbonyls Metabolite 4-Methoxybenzyl formate Family 1 7
Phenylacetic Acid Derivatives Metabolite Guaicyl phenylacetate... 1 3
Benzofurans Metabolite (R)-Bitalin A Family 1 9
Putative NP ZINC31165975 Family 4 0
Putative NP ZINC31158464 Family 3 5
Putative NP ZINC04043753 Family 8 6
NP 6-(4-ethoxyphenyl)-1,3-dimethyl-4-oxo-4h-cyclohepta[c]furan... 13 3
2-(2-methoxyphenyl)-5-oxooxolane-3-carboxylate NP ZINC00132596... 4 2
NP Agn-pc-05wmi6 Family 2 0
3-pentyl-5-(phenoxymethyl)oxolan-2-one NP ZINC02116245 Family 4 0
2-[(3,4-dimethoxyphenyl)methyl]propanedioate NP 4aji Family 1 0
5-(4-methoxyphenyl)-2,2-dimethyloxolan-3-one NP 5-(4-methoxyph... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00224691 CHEMBL446893 Bioactive (2S)-2-ethoxy-3-[4-[(E)-5-phenylpent-2-en-4-ynoxy]phenyl]propanoic acid
CFAMM00224752 CHEMBL321689 Bioactive AGN-PC-074YHA
CFAMM00224771 CHEMBL432243 Bioactive AGN-PC-074YCZ
CFAMM00224785 CHEMBL432618 Bioactive SureCN7365883
CFAMM00224684 DNC005195 Investigative Drug TESAGLITAZAR
CFAMM00224768 DNC003345 Investigative Drug (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid
CFAMM00224767 DNC003344 Investigative Drug (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid
CFAMM00224721 DNC004451 Investigative Drug 8-(Biphenyl-4-yloxy)-2-oxo-octanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

42900 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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