CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1011
Family Name Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide Family
No. of Seeds 12 No. of Other Members 44
Family Centroid CFAMM00224974 Functional Category Investigative Drug
Superfamily Carbonic anhydrase 2 and Carbonic anhydrase 1 Binder Superfamily
Class Class 905

Cousin Family NamesSeedsMembers
SUR1-type K(ATP) channel and SUR2-type K(ATP) channel Ligand T... 3 35
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
ATP-sensitive inward rectifier potassium channel 10 Ligand Ace... 2 64
DNA Binder Procarbazine Family 8 358
Cathepsin K Inhibitor Odanacatib Family 33 84
C-C chemokine receptor type 5 Ligand AZD5672 Family 25 70
Bavisant family 9 65
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Chloride channel protein 2 Ligand Acid-activated Omeprazole Fa... 1 1
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Suppressor of tumorigenicity 14 protein and Prothrombin Inhibi... 4 126
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
72 kDa type IV collagenase Inhibitor SC-74020 Family 1 21
Thymidylate synthase Inhibitor N-[tosyl-d-prolinyl]amino-ethan... 1 10
Thymidylate synthase Inhibitor Sp-876 Family 7 117
Penicillin-binding protein 1B Inhibitor N-benzoyl-d-alanine Fa... 1 40
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor N-(4-s... 12 92
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Potassium voltage-gated channel subfamily A member 5 Ligand N-... 8 32
Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic ... 7 13
Integrin beta-3 Inhibitor L-750034 Family 7 38
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-hydr... 3 14
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 2-acet... 6 2
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 2-pent... 4 5
Vascular endothelial growth factor receptor 1 and Vascular end... 5 22
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 2-valp... 8 5
Suppressor of tumorigenicity 14 protein Inhibitor 3-tapap Family 15 39
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Saccha... 2 13
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 6 19
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Trypsin Inhibitor Benzamidrazone Analogue Family 16 6
72 kDa type IV collagenase and Collagenase 3 inhibitor SureCN7... 1 8
C-C chemokine receptor type 2 ligand SureCN2988733 family 14 17
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor AGN-PC... 2 5
Muscarinic acetylcholine receptor M2 ligand [4-[(3R)-3-methyl-... 3 4
Acetylcholinesterase and Butyrylcholinesterase inhibitor N-[2-... 3 7
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2,5-dichlor... 3 4
Cathepsin L1 and Cathepsin B inhibitor (2S)-3-methyl-N-[(2S)-4... 7 24
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-044L... 6 7
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 1
Neprilysin inhibitor AGN-PC-047EOK family 7 4
Neprilysin inhibitor AGN-PC-047EP1 family 1 0
D(2) dopamine receptor and D(3) dopamine receptor ligand 1,1-d... 2 7
Cannabinoid receptor 2 ligand 4-methyl-3-piperidin-1-ylsulfony... 2 0
Acetylcholinesterase inhibitor N-[2-(1-benzylpiperidin-4-yl)et... 1 0
Type-1 angiotensin II receptor ligand AGN-PC-09QIDT family 2 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-met... 8 13
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Replication protein E1 inhibitor AC1LAK2U family 3 10
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor 2-[2-[... 10 5
Kappa-type opioid receptor and Delta-type opioid receptor liga... 9 0
Poly [ADP-ribose] polymerase 1 inhibitor SureCN2769748 family 1 1
Bifunctional epoxide hydrolase 2 inhibitor N-cycloheptyl-1-(2,... 7 8
Cathepsin K and Cathepsin L1 inhibitor N-[1-(cyanomethylcarbam... 2 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 12 5
B1 bradykinin receptor and B2 bradykinin receptor ligand SureC... 3 0
Cannabinoid receptor 2 ligand AC1PDO4X family 2 4
Cannabinoid receptor 2 ligand AGN-PC-04VLWN family 9 4
Cannabinoid receptor 2 ligand N-cyclohexyl-4-propan-2-yl-3-pyr... 2 2
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Neutrophil elastase inhibitor diethyl (1,1,3-trioxo-4-propan-2... 2 0
5-hydroxytryptamine receptor 1A and Alpha-2B adrenergic recept... 2 2
Carbonic anhydrase 2 inhibitor N-[(4-nitrophenyl)methyl]-4-sul... 1 2
C-C chemokine receptor type 5 ligand N-[1-[(3R)-4-[benzenesulf... 3 1
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-bromobenz... 1 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (3R)-3-... 3 2
Carbonic anhydrase 2 inhibitor benzyl 2-[[2-[[(2S)-3-phenyl-2-... 2 9
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[ethyl-[2-(4... 1 1
Cannabinoid receptor 1 ligand 1-[4-[3-cyclopropyl-5-(trifluoro... 4 1
C-C chemokine receptor type 2 ligand AGN-PC-03L0Z6 family 1 1
Growth hormone secretagogue receptor type 1 ligand [(3S)-3-ami... 2 6
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 5
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor KB-74... 2 0
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2J2 inhib... 5 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor N-... 1 0
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor 2-[car... 1 0
Caspase-3 inhibitor 3-oxo-N-(2-phenylethyl)-1,2-benzothiazole-... 1 3
Lethal(3)malignant brain tumor-like protein 3 and Lethal(3)mal... 1 0
C-C chemokine receptor type 5 ligand AC1NUL29 family 1 0
Bifunctional epoxide hydrolase 2 and Lysosomal alpha-glucosida... 9 3
Secreted frizzled-related protein 1 and Proto-oncogene Wnt-3 i... 2 5
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor AGN-PC... 2 9


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00224958 CHEMBL66907 Bioactive IOC
CFAMM00224941 CHEMBL65268 Bioactive N-[(2-methylphenyl)methyl]-4-sulfamoylbenzamide
CFAMM00224956 CHEMBL302105 Bioactive N-(1-adamantylmethyl)-4-sulfamoylbenzamide
CFAMM00224946 DNC006917 Investigative Drug N-(prop-2-ynyl)-4-sulfamoylbenzamide
CFAMM00224910 DNC003372 Investigative Drug 4-Sulfonamide-[1-(4-Aminobutane)]Benzamide
CFAMM00224922 DNC003381 Investigative Drug N-(2,3-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE
CFAMM00224909 DNC003373 Investigative Drug N-(2,6-Diflouro-Benzyl)-4-Sulfamoyl-Benzamide
CFAMM00224932 DNC007982 Investigative Drug N-benzyl-N-(phenylsulfonyl)benzamide
CFAMM00224975 DNC003359 Investigative Drug N-(2-Flouro-Benzyl)-4-Sulfamoyl-Benzamide
CFAMM00224974 DNC003357 Investigative Drug N-Benzyl-4-Sulfamoyl-Benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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