CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1014
Family Name Carbonic anhydrase 2 Inhibitor Cyanamide Family
No. of Seeds 2 No. of Other Members 32
Family Centroid CFAMM00225005 Functional Category Investigative Drug
Superfamily Carbonic anhydrase 2 and Dipeptidyl peptidase 4 Binder Superfamily
Class Class 1373

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 5 60
SUR2-type K(ATP) channel Ligand Pinacidil Family 1 8
G protein-activated inward rectifier potassium channel 4 Ligan... 3 48
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 23 63
Histone deacetylase 1 Inhibitor Pyroxamide Family 4 13
Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family 11 42
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand 3-benz... 1 6
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Cathepsin K Inhibitor 2-cyclohexylamino-pyridine-2-carbonitril... 1 2
Transient receptor potential cation channel subfamily V member... 2 26
Farnesyl pyrophosphate synthase Inhibitor Piridronic Acid Family 3 14
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 2-(4-... 8 25
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 9 24
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Macrophage migration inhibitory factor Inhibitor 1-(2-chloroph... 2 22
Reverse transcriptase Inhibitor PT-102 Family 8 12
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Reverse transcriptase Inhibitor PT-109 Family 6 7
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Tyrosinase Inhibitor 5-(pyridin-4-yl)-1,3,4-thiadiazole-2(3h)-... 1 1
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 4 5
Acetylcholinesterase and Cholinesterase inhibitor 2-amino-6-[3... 1 4
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 8 0
Androgen receptor ligand AGN-PC-009ZOP family 3 3
Farnesyl pyrophosphate synthase inhibitor AC1NQOV1 family 2 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 10 1
Neuropeptide Y receptor type 5 ligand SureCN4464548 family 17 2
D-amino-acid oxidase and D-aspartate oxidase inhibitor naphthy... 2 2
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Cannabinoid receptor 2 ligand AGN-PC-07CRHA family 4 8
Reverse transcriptase/RNaseH inhibitor 181305-52-2 family 1 0
Hormone-sensitive lipase inhibitor AGN-PC-074W3L family 1 2
Metabotropic glutamate receptor 5 ligand AGN-PC-075XWO family 2 0
Neuronal acetylcholine receptor subunit alpha-3 and Neuronal a... 1 5
Nitric oxide synthase, brain inhibitor SureCN1387416 family 2 0
Putative NP ZINC19701930 Family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00225035 CHEMBL55140 Bioactive AC1NQOUV
CFAMM00225005 DNC003363 Investigative Drug Cyanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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