CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1020
Family Name Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor N-(4-sulfamoyl-phenyl)-benzamide Family
No. of Seeds 12 No. of Other Members 92
Family Centroid CFAMM00225188 Functional Category Investigative Drug with Natural Product
Superfamily Carbonic anhydrase 1 and Carbonic anhydrase 2 Binder Superfamily 4
Class Class 1934

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Mannose-6-phosphate isomerase Inhibitor Sulfacetamide Family 19 117
Mannose-6-phosphate isomerase Inhibitor Sulfanilamide Family 4 8
Serum albumin Inhibitor Ebselen Family 3 62
Histone deacetylase 1 Inhibitor PXD101 Family 3 24
5-hydroxytryptamine receptor 1A and Sigma non-opioid intracell... 7 28
Pan-DAC Inhibitor AR-42 Family 21 153
Caspase-3 Inhibitor 5-(pyrrolidin-1-ylsulfonyl)indoline-2,3-di... 5 35
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
72 kDa type IV collagenase Inhibitor SC-74020 Family 1 21
Aldose reductase Inhibitor Inhibitor Idd 384 Family 1 3
Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... 12 44
Potassium voltage-gated channel subfamily A member 5 Ligand N-... 8 32
Integrin beta-3 Inhibitor L-750034 Family 7 38
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 2-morp... 6 81
Vascular endothelial growth factor receptor 1 and Vascular end... 1 4
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-[2-(... 5 72
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 3-(3-p... 7 17
5-hydroxytryptamine receptor 6 Ligand N-(3-(2-aminoethyl)pheny... 8 25
C-C chemokine receptor type 8 Ligand N-(4-phenylsulfamoyl-naph... 4 62
Transient receptor potential cation channel subfamily V member... 1 5
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 5 10
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 7 2
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor 3-((4-... 5 4
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 2
Interstitial collagenase and Neutrophil collagenase inhibitor ... 3 9
72 kDa type IV collagenase and Collagenase 3 inhibitor SureCN7... 1 8
72 kDa type IV collagenase and Collagenase 3 inhibitor SureCN7... 1 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04TGG7 family 2 3
Prostaglandin E2 receptor EP3 subtype ligand (E)-3-[1-(naphtha... 13 5
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor 2-amin... 2 2
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor 2-[car... 3 3
Pol polyprotein inhibitor Lysine Sulfonamide 11o family 2 6
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor 2,2,3,... 2 1
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 3 0
Cellular tumor antigen p53 inhibitor CHEMBL1554992 family 1 0
Neprilysin inhibitor AGN-PC-047EOR family 2 3
D(2) dopamine receptor and D(3) dopamine receptor ligand 1,1-d... 2 7
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 1 1
Coagulation factor X and Trypsin-1 inhibitor SureCN6161266 family 2 28
Cannabinoid receptor 2 ligand 4-methyl-3-piperidin-1-ylsulfony... 2 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 1-(2-c... 1 1
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 5 1
Protein-glutamine gamma-glutamyltransferase 2 and Coagulation ... 1 0
Inosine-5'-monophosphate dehydrogenase 2 inhibitor SureCN32339... 2 2
Bifunctional epoxide hydrolase 2 inhibitor 1-(2,4-dimethylphen... 4 8
Bifunctional epoxide hydrolase 2 inhibitor N-(2-chlorophenyl)-... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-[[4... 7 11
Carbonic anhydrase 12 and Carbonic anhydrase 9 inhibitor (E)-2... 2 0
Carbonic anhydrase 12 and Carbonic anhydrase 2 inhibitor (1E)-... 1 0
Carbonic anhydrase 9 and Carbonic anhydrase 12 inhibitor (2Z)-... 1 0
Carbonic anhydrase 12 and Carbonic anhydrase 9 inhibitor (E)-3... 2 0
Collagenase 3 and Neutrophil collagenase inhibitor (2R)-2-[ben... 2 12
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltra... 5 10
Cannabinoid receptor 2 ligand N-cyclohexyl-4-propan-2-yl-3-pyr... 2 2
Coagulation factor X and Trypsin-1 inhibitor SureCN7690621 family 12 20
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 5 14
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor (4R)-N... 2 22
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 3 0
Carbonic anhydrase 2 inhibitor N-[(4-nitrophenyl)methyl]-4-sul... 1 2
Scytalone dehydratase inhibitor (E)-N-[[4-[(2,5-difluorophenyl... 1 0
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 0
Amine oxidase [flavin-containing] A inhibitor N-(6-ethyl-9,10,... 1 5
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 1 0
B1 bradykinin receptor and Potassium voltage-gated channel sub... 1 1
B1 bradykinin receptor ligand AGN-PC-04TG1P family 4 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor KB-74... 2 0
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor N-(2,3... 2 2
Carbonic anhydrase and Carbonic anhydrase 2 inhibitor AGN-PC-0... 2 0
Protein-glutamine gamma-glutamyltransferase 2 and Coagulation ... 3 2
Aldo-keto reductase family 1 member C3 inhibitor 2-[3-(3,4-dih... 1 0
Histidinol dehydrogenase inhibitor 2-(1-benzyl-2-oxo-5-thiomor... 1 4
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00225224 CHEMBL77359 Bioactive AGN-PC-007DUJ
CFAMM00225265 CHEMBL2402765 Bioactive 2-(4-fluorophenyl)-N-(4-sulfamoylphenyl)acetamide
CFAMM00225263 CHEMBL2402769 Bioactive 2-(4-fluorophenyl)-N-(2-fluoro-4-sulfamoylphenyl)acetamide
CFAMM00225287 CHEMBL75747 Bioactive AGN-PC-004OB9
CFAMM00225192 CHEMBL76956 Bioactive 2,3,5,6-tetrafluoro-N-(3-sulfamoylphenyl)benzamide
CFAMM00225228 CHEMBL74491 Bioactive AGN-PC-00A1VV
CFAMM00225198 CHEMBL2337533 Bioactive (2E,4E)-2-cyano-5-phenyl-N-(4-sulfamoylphenyl)penta-2,4-dienamide
CFAMM00225267 DNC009942 Investigative Drug 4-(2-Phenylacetamido)-3-fluorobenzenesulfonamide
CFAMM00225214 DNC009939 Investigative Drug 4-(2-Phenylacetamido)benzenesulfonamide
CFAMM00225175 DNC003379 Investigative Drug N-[4-(AMINOSULFONYL)PHENYL]-2-MERCAPTOBENZAMIDE
CFAMM00225188 DNC005755 Investigative Drug N-(4-Sulfamoyl-phenyl)-benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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