CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1040
Family Name Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phenethyl-urea Family
No. of Seeds 3 No. of Other Members 12
Family Centroid CFAMM00225743 Functional Category Investigative Drug
Superfamily Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phenethyl-urea Superfamily
Class Class 1148

Cousin Family NamesSeedsMembers
Beta adrenergic receptor Ligand Bethanidine Family 2 22
Alpha-1B adrenergic receptor ligand phenethylamine derivative ... 12 283
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Substance-P receptor Ligand Vestipitant Family 14 137
Reverse transcriptase Inhibitor 3-benzylamino-5-ethyl-6-methyl... 2 24
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Glycogen synthase kinase-3 Inhibitor NP12 Family 3 5
Renin Inhibitor N-methyl-n-(methylbenzyl)formamide Family 2 17
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-[1-(4-isobut... 1 7
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondria... 2 3
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 11 6
Histamine H3 receptor Ligand N-benzyl-4-cyclopentylpiperazine-... 3 19
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Sodium-dependent serotonin transporter Inhibitor Irindalone Fa... 16 9
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
Aminopeptidase N Inhibitor 2-benzyl-n1-hydroxy-n3-(4-phenylbut... 5 3
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
DNA topoisomerase Inhibitor 6-benzylamino-1h-pyrimidine-2,4-di... 3 3
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 4 13
Cellular tumor antigen p53 and Retinal dehydrogenase 1 inhibit... 1 4
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 6
C-C chemokine receptor type 3 ligand 1-(2,3-dimethyl-3a,7a-dih... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 2 5
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 4 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 1
Prostaglandin E synthase inhibitor AGN-PC-09QMEJ family 2 0
Histamine H3 receptor ligand (2S)-N-(2,3-dihydro-1H-inden-2-yl... 2 1
Urease inhibitor 1-$l^{1}-selanyl-N,N-dimethyl-N'-[(1S)-1-naph... 1 0
Histamine H3 receptor ligand AGN-PC-077LOO family 1 4
Acetylcholinesterase inhibitor (E)-1-N'-benzyl-1-N-[2-(1-benzy... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00225732 DNC003417 Investigative Drug N-Cyclohexyl-N'-(Propyl)Phenyl Urea
CFAMM00225736 DNC014036 Investigative Drug 1,3-dibenzyl urea
CFAMM00225743 DNC005559 Investigative Drug 1-Cyclohexyl-3-phenethyl-urea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27634 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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