CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID105
Family Name 5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine receptor 6 Ligand 3-(2-amino-ethyl)-2-methyl-1h-indol-5-ol Family
No. of Seeds 11 No. of Other Members 41
Family Centroid CFAMM00181132 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Androgen receptor and Oestrogen receptor Binder Superfamily
Class Class 1404

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA Binder Primaquine Family 3 245
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
5-hydroxytryptamine receptor 3A Ligand Dolasetron Family 12 171
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Gastrin/cholecystokinin type B receptor ligand oligopeptide Ce... 35 209
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
DNA Binder Elliptinium Acetate Family 11 116
Citric Acid family 2 58
Fibroblast growth factor receptor 1 and Aurora kinase B Inhibi... 4 51
Substance-P receptor Ligand GSK424887 Family 8 184
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Apricoxib family 8 77
Indeglitazar family 3 39
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Oestrogen receptor and Estrogen receptor beta Ligand ZK-119010... 2 16
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 0
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Serine/threonine-protein kinase Chk1 and Wee1-like protein kin... 2 101
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
Glycogen synthase kinase-3 beta Inhibitor 6-hydroxymanzamine A... 3 0
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3,3'-pyrazine-2,5-... 2 14
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Indoleamine 2,3-dioxygenase 1 Inhibitor 5-aminoquinolin-8-ol F... 3 16
Cyclin-dependent kinase 2 and G1/S-specific cyclin-E1 Inhibito... 5 1
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35
Androgen receptor Ligand 11-methyl-6,11-dihydro-5h-benzo[a]car... 7 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Prostaglandin G/H synthase 2 Inhibitor 5-methoxy-2-(4-(methyls... 3 12
Phospholipase A2 Inhibitor Hyrtiosulawesine Family 1 3
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 1
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
Kinesin-like protein KIF11 inhibitor AGN-PC-080PZM family 1 11
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 10
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 10
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 5
5-hydroxytryptamine receptor 6 ligand SureCN5502542 family 4 2
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Gonadotropin-releasing hormone receptor ligand AGN-PC-075RJQ f... 3 0
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Androgen receptor ligand (6R,7S)-6-ethyl-7-methyl-4-(trifluoro... 22 29
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Progesterone receptor and Androgen receptor ligand AGN-PC-04QD... 1 0
Glucocorticoid receptor ligand SureCN5650626 family 17 25
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Glucocorticoid receptor ligand AGN-PC-0A9RHA family 1 2
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00CFYH ... 2 1
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 2 0
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 2 11
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 3 6
Integrase inhibitor (Z)-4-[1-[(4-fluorophenyl)methyl]-5-methox... 1 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 1 1
Transient receptor potential cation channel subfamily V member... 1 5
Estrogen receptor beta and Estrogen receptor ligand 2-fluoro-4... 1 0
5-hydroxytryptamine receptor 2A ligand (3R,4R)-3-(2-phenyl-1H-... 1 18
Proto-oncogene tyrosine-protein kinase receptor Ret ligand Sur... 1 1
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-(2-nitropheno... 1 6
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Transient receptor potential cation channel subfamily V member... 6 1
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 1 2
Beta-3 adrenergic receptor ligand 3-[2-[[(2R)-2-(3-chloropheny... 1 1
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
D(1A) dopamine receptor and D(3) dopamine receptor ligand RU-2... 3 4
5-hydroxytryptamine receptor 6 ligand 1-[9-(2,5-dimethoxypheny... 2 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 7
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 7 1
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aS... 2 1
Androgen receptor ligand SureCN1990713 family 1 0
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 4 3
Acetylcholinesterase and Cholinesterase inhibitor P10358 family 2 0
Phospholipase A2, membrane associated inhibitor 2-(1-benzyl-2-... 2 1
Carbonic anhydrase 2 inhibitor 6-hydroxy-1H-indole-2-sulfonami... 2 0
Kinesin-like protein KIF11 inhibitor AGN-PC-07R5ZC family 1 5
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-074... 1 0
Insulin receptor ligand 2,5-dihydroxy-3-(1H-indol-3-yl)-6-phen... 1 0
Aldose reductase and Aldo-keto reductase family 1 member B10 i... 1 2
Proto-oncogene tyrosine-protein kinase Src and cAMP-dependent ... 2 0
Proto-oncogene tyrosine-protein kinase Src and cAMP-dependent ... 2 0
Proto-oncogene tyrosine-protein kinase Src and cAMP-dependent ... 1 0
Carbonic anhydrase 4 and Carbonic anhydrase 2 inhibitor 5,10-d... 3 1
Proto-oncogene tyrosine-protein kinase Src and cAMP-dependent ... 2 0
Sugar Acids and Derivatives Metabolite 6-Hydroxy-5-methoxyindo... 3 1
Indoles Metabolite 4-[N-(p-Coumaroyl)serotonin-4''-yl]-N-ferul... 3 0
1-[(5-hydroxy-1H-indol-3-yl)methyl]-5'-methyl-5-phenylspiro[1,... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00181172 CHEMBL1628597 Bioactive [3H]5-HT
CFAMM00181149 CHEMBL535832 Bioactive Serotonin hydrochloride
CFAMM00181173 DNC000086 Investigative Drug 5-hydroxy-1H-indole-3-acetic acid
CFAMM00181171 DNC002841 Investigative Drug 3h-Indole-5,6-Diol
CFAMM00181132 DNC003577 Investigative Drug 3-(2-Amino-ethyl)-2-methyl-1H-indol-5-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

44434 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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